Intramuscular adipose tissue and central activation in older adults
Abstract
INTRODUCTION: Intramuscular adipose tissue (IMAT) is a potential contributor to declining force production and may be related to impaired central activation; therefore, the purpose of this report is to describe IMAT composition and its association with central activation in older adults. The central activation ratio (CAR) of the knee extensors was assessed using a superimposition technique in 15 older adults (29 legs) along with the cross-sectional area of IMAT and lean tissue. RESULTS: IMAT and CAR are inversely related in older adults (r = -0.51, P = 0.005), and many subjects with high IMAT have deficits in central activation, whereas those with low IMAT have normal central activation. CONCLUSIONS: These novel findings may assist in unraveling why muscle force production and lean tissue cross-sectional area are not strongly linked, as the ability to centrally activate muscle appears to be unrelated to lean muscle area and may be dependent in part on IMAT levels.
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When fatty infiltration increases, there is a decrease in central activation ratio of a muscle, meaning diminished ability to fully voluntarily activate a muscle.
“At least one study has demonstrated that when fatty infiltration increases, there is a decrease in the central activation ratio of a muscle, meaning a diminished ability to fully voluntarily activate a muscle (Yoshida et al., 2012).”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Yoshida et al., 2012
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Additional file 1 of Mid-life cyclists preserve muscle mass and composition: a 3D MRI study
Belzunce, M. A., Henckel, J., Laura, A. D., Horga, L. M., & Hart, A. J. (2024) · Figshare · doi:10.6084/m9.figshare.26576072
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Blood Flow Restriction in Older Adults: Implications and Interventions for Sarcopenia Management
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Myosteatosis: an emerging biomarker of aging
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- Authors
- Yoshida, Y., Marcus, R. L., & Lastayo, P. C.
- Affiliations
- University of Utah (US)
- Corresponding author
- Lastayo, Paul C.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2012-10-10
- Volume
- 46
- Issue
- 5
- Pages
- 813-816
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2057118310
- Cited by
- 90
- References
- 32
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 14 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 3
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k12hd043449-05)
- National Institute on Aging (R01AG031255)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064814)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12 HD043449)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- intramuscular fat, central activation, older adults, knee extensors, central activation ratio, muscle force production, sarcopenia
- MeSH terms
- Adipose Tissue, Aged, Aged, 80 and over, Aging, Body Composition, Female, Humans, Isometric Contraction, Male, Middle Aged, Muscle, Skeletal
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