Cited by 9Muscle Physiology and DisordersThyroid Disorders and TreatmentsExercise and Physiological Responses

Isoflavin-β Modifies Muscle Oxidative Stress and Prevents a Thyrotoxicosis-Induced Loss of Muscle Mass in Rats

Marinello, Poliana C., Bernardes, Sara S., Guarnier, Flávia A., Da Silva, Thamara N.X., Borges, Fernando H., Lopes, Natália M.D., Simão, Andréa N.C., Armani, André +2 more·2017·Muscle & Nerve

Abstract

INTRODUCTION: We sought to verify whether isoflavin-beta (Iso-β), a mixture of isoflavones with antioxidant properties, could prevent thyrotoxicosis-induced loss of muscle mass and the participation of oxidative stress (OS) in the mechanisms of this prevention. METHODS: Two experimental periods of thyrotoxicosis induction were used in Wistar rats: 3 and 5 days to assess Iso-β effects before and after thyrotoxicosis-induced muscle wasting. After euthanasia, peritoneal fat and gastrocnemius muscle were collected, weighed, and muscle OS was assessed. RESULTS: Iso-β prevented the loss of gastrocnemius mass in thyrotoxic rats through the prevention of muscle OS generation during thyrotoxicosis, increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome c oxidase activity, lipid peroxidation, and protein carbonyl content. CONCLUSION: Iso-β decreased oxidative modification of proteins, which is known to exert a major role during proteolysis induction and is present in thyrotoxic myopathy, highlighting the potential action of Iso-β in this complication of the disease. Muscle Nerve 56: 975-981, 2017.

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Crossref · 10.1002/mus.25546

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  • Daily intraperitoneal injections of isoflavin-β prevent thyrotoxicosis-induced muscle mass loss in Wistar rats through increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome oxidase activity.

    “Daily intraperitoneal injections of isoflavin-β, a mixture of isoflavones, prevents thyrotoxicosis-induced muscle mass loss in Wistar rats through increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome oxidase activity [116].”

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Authors
Marinello, P. C., Bernardes, S. S., Guarnier, F. A., Da Silva, T. N. X., Borges, F. H., Lopes, N. M. D., Simão, A. N. C., Armani, A., Cecchini, R., & Cecchini, A. L.
Affiliations
  • Universidade Estadual de Londrina (BR)
  • Laboratory of Pathophysiology and Muscle Adaptation State University of Londrina Londrina Paraná Brazil
  • Laboratory of Pathophysiology and Free Radicals State University of Londrina Londrina Paraná Brazil
Corresponding author
Cecchini, Alessandra L.
Venue
Muscle & Nerve
Publisher
Wiley
Published
2017-03-24
Volume
56
Issue
5
Pages
975-981
ISSN
  • 0148-639X (ISSN-L)
  • 1097-4598
OpenAlex
W2567590068
Cited by
9
References
42
Citations by year
2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 1
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Locations
  • Muscle & Nerve (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
isoflavones, thyrotoxicosis, thyrotoxic myopathy, muscle mass loss, gastrocnemius, antioxidant capacity, protein carbonylation, lipid peroxidation, cytochrome c oxidase, muscle protein degradation
MeSH terms
Animals, Antioxidants, Chymotrypsin, Cyclohexanols, Electron Transport Complex IV, Disease Models, Animal, Drug Administration Schedule, Glycerol, Isoflavones, Male, Muscular Atrophy, Superoxide Dismutase, Thyrotoxicosis, Rats, Wistar, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Muscle, Skeletal, tert-Butylhydroperoxide, Protein Carbonylation, Rats

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