Isoflavin-β Modifies Muscle Oxidative Stress and Prevents a Thyrotoxicosis-Induced Loss of Muscle Mass in Rats
Abstract
INTRODUCTION: We sought to verify whether isoflavin-beta (Iso-β), a mixture of isoflavones with antioxidant properties, could prevent thyrotoxicosis-induced loss of muscle mass and the participation of oxidative stress (OS) in the mechanisms of this prevention. METHODS: Two experimental periods of thyrotoxicosis induction were used in Wistar rats: 3 and 5 days to assess Iso-β effects before and after thyrotoxicosis-induced muscle wasting. After euthanasia, peritoneal fat and gastrocnemius muscle were collected, weighed, and muscle OS was assessed. RESULTS: Iso-β prevented the loss of gastrocnemius mass in thyrotoxic rats through the prevention of muscle OS generation during thyrotoxicosis, increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome c oxidase activity, lipid peroxidation, and protein carbonyl content. CONCLUSION: Iso-β decreased oxidative modification of proteins, which is known to exert a major role during proteolysis induction and is present in thyrotoxic myopathy, highlighting the potential action of Iso-β in this complication of the disease. Muscle Nerve 56: 975-981, 2017.
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Daily intraperitoneal injections of isoflavin-β prevent thyrotoxicosis-induced muscle mass loss in Wistar rats through increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome oxidase activity.
“Daily intraperitoneal injections of isoflavin-β, a mixture of isoflavones, prevents thyrotoxicosis-induced muscle mass loss in Wistar rats through increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome oxidase activity [116].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [116]
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- Authors
- Marinello, P. C., Bernardes, S. S., Guarnier, F. A., Da Silva, T. N. X., Borges, F. H., Lopes, N. M. D., Simão, A. N. C., Armani, A., Cecchini, R., & Cecchini, A. L.
- Affiliations
- Universidade Estadual de Londrina (BR)
- Laboratory of Pathophysiology and Muscle Adaptation State University of Londrina Londrina Paraná Brazil
- Laboratory of Pathophysiology and Free Radicals State University of Londrina Londrina Paraná Brazil
- Corresponding author
- Cecchini, Alessandra L.
- ORCID
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2017-03-24
- Volume
- 56
- Issue
- 5
- Pages
- 975-981
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2567590068
- Cited by
- 9
- References
- 42
- Citations by year
- 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- isoflavones, thyrotoxicosis, thyrotoxic myopathy, muscle mass loss, gastrocnemius, antioxidant capacity, protein carbonylation, lipid peroxidation, cytochrome c oxidase, muscle protein degradation
- MeSH terms
- Animals, Antioxidants, Chymotrypsin, Cyclohexanols, Electron Transport Complex IV, Disease Models, Animal, Drug Administration Schedule, Glycerol, Isoflavones, Male, Muscular Atrophy, Superoxide Dismutase, Thyrotoxicosis, Rats, Wistar, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Muscle, Skeletal, tert-Butylhydroperoxide, Protein Carbonylation, Rats
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