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Cited by 440Exercise and Physiological ResponsesMuscle Physiology and DisordersRedox biology and oxidative stress

Reactive Oxygen Species Are Signalling Molecules for Skeletal Muscle Adaptation

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Powers, Scott K., Duarte, Jose, Kavazis, Andreas N., Talbert, Erin E.·2010·Experimental Physiology
DOI 10.1113/expphysiol.2009.050526PMC PMC2906150
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Abstract

Increased reactive oxygen species (ROS) production is crucial to the remodelling that occurs in skeletal muscle in response to both exercise training and prolonged periods of disuse. This review discusses the redox‐sensitive signalling pathways that are responsible for this ROS‐induced skeletal muscle adaptation. We begin with a discussion of the sites of ROS production in skeletal muscle fibres. This is followed by an overview of the putative redox‐sensitive signalling pathways that promote skeletal muscle adaptation. Specifically, this discussion highlights redox‐sensitive kinases, phosphatases and the transcription factor nuclear factor‐κB. We also discuss the evidence that connects redox signalling to skeletal muscle adaptation in response to increased muscular activity (i.e. exercise training) and during prolonged periods of muscular inactivity (i.e. immobilization). In an effort to stimulate further research, we conclude with a discussion of unanswered questions about redox signalling in skeletal muscle.

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  • It is likely that oxidative stress enhances proteolysis via the calpain and caspase pathways, although this has not been directly demonstrated in COPD muscle.

    “It is also likely that oxidative stress enhances proteolysis via the calpain and caspase pathways [133], whereas this has not been directly demonstrated in COPD muscle.”

    From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [133]

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Authors
Powers, S. K., Duarte, J., Kavazis, A. N., & Talbert, E. E.
Affiliations
University of Florida (US)
ORCID
Venue
Experimental Physiology
Publisher
Wiley
Published
2009-12-15
Volume
95
Issue
1
Pages
1-9
ISSN
  • 0958-0670 (ISSN-L)
  • 1469-445X
DOI
10.1113/expphysiol.2009.050526
PMC
PMC2906150
OpenAlex
W1556889952
Cited by
440
References
5
Citations by year
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FWCI
2.58
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Experimental Physiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL062361)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
reactive oxygen species, redox signaling, skeletal muscle adaptation, exercise training, disuse, muscle remodeling, NF-κB, immobilization
MeSH terms
Adaptation, Physiological, Animals, Humans, Muscle Contraction, Signal Transduction, Exercise, Reactive Oxygen Species, Muscle, Skeletal

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