Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway
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Skeletal muscle atrophy induced by aging (sarcopenia), inactivity, and prolonged fasting states (starvation) is predominantly restricted to glycolytic type II muscle fibers and typical spares oxidative type I fibers. However, the mechanisms accounting for muscle fiber-type specificity of atrophy have remained enigmatic. In the current study, although the Fyn tyrosine kinase activated the mTORC1 signaling complex, it also induced marked atrophy of glycolytic fibers with relatively less effect on oxidative muscle fibers. This was due to inhibition of macroautophagy via an mTORC1-independent but STAT3-dependent reduction in Vps34 protein levels and decreased Vps34/p150/Beclin1/Atg14 complex 1. Physiologically, in the fed state endogenous Fyn kinase activity was increased in glycolytic but not oxidative skeletal muscle. In parallel, Y705-STAT3 phosphorylation increased with decreased Vps34 protein levels. Moreover, fed/starved regulation of Y705-STAT3 phosphorylation and Vps34 protein levels was prevented in skeletal muscle of Fyn null mice. These data demonstrate a Fyn/STAT3/Vps34 pathway that is responsible for fiber-type-specific regulation of macroautophagy and skeletal muscle atrophy.
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STAT3 negatively regulates both PIK3C3 and BECN1 through recruitment of HDAC3 on its promoter.
“STAT3 also negatively regulates both PIK3C3 (Yamada et al., 2012) and BECN1 (Miao et al., 2014) through recruitment of HDAC3 on its promoter (Miao et al., 2014).”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Yamada et al., 2012
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Fasting Diets and Vascular Health: Scoping Review with ☸SAIMSARA
SAIMSARA (2026) · SAIMSARA Journal · doi:10.62487/93074bf6
- Authors
- Yamada, E., Bastie, C. C., Koga, H., Wang, Y., Cuervo, A. M., & Pessin, J. E.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Pessin, Jeffrey E.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 1
- Issue
- 5
- Pages
- 557-569
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC3383827
- OpenAlex
- W2082905129
- Cited by
- 103
- References
- 52
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 6 · 2014: 1 · 2013: 13
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK033823, R01DK082694, R37DK033823, DK-082694, DK-020541, DK033823, P60DK020541, P30DK020541)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- skeletal muscle atrophy, muscle atrophy, macroautophagy, Fyn tyrosine kinase, STAT3 phosphorylation, Vps34, mTORC1, Beclin-1, starvation, sarcopenia
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Animals, Autophagy, Disease Models, Animal, Mice, Transgenic, Muscular Atrophy, Phenotype, Proteins, Signal Transduction, Apoptosis, Muscle Fibers, Skeletal, Muscle Weakness, Multiprotein Complexes, STAT3 Transcription Factor, Proto-Oncogene Proteins c-fyn, Mice, Class III Phosphatidylinositol 3-Kinases, TOR Serine-Threonine Kinases
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