High‐field MRI of single histological slices using an inductively coupled, self‐resonant microcoil: application to ex vivo samples of patients with Alzheimer's disease
Abstract
A simple inductively coupled microcoil has been designed to image tissue samples placed on a microscope slide, samples which can subsequently be stained histologically. As the exact same tissue is used for MRI and histology, the two data sets can be compared without the need for complicated image registration techniques. The design can be integrated into any MRI system using existing commercial hardware. Compared with a commercial 25-mm-diameter birdcage, the signal-to-noise ratio was increased by a factor of 3.8, corresponding to an approximate 15-fold reduction in the data acquisition time. An example is shown of ex vivo samples from patients with Alzheimer's disease, in which the coregistration of highly sensitive iron staining and amyloid-β deposits is confirmed.
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MRI scans of post-mortem human brains and a mouse model of Alzheimer's disease show decreases in hippocampal T2* MRI, which is sensitive to the magnetic properties of iron or its spatial variance, attributed in part to iron in Aβ plaques.
“MRI scans of post-mortem human brains and a mouse model of Alzheimer’s disease show decreases in hippocampal T2* MRI, which is sensitive to the magnetic properties of iron86,87 or its spatial variance, attributed in part to iron in Aβ plaques.88–90”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [89]
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- Authors
- Nabuurs, R. J. A., Hegeman, I., Natté, R., van Duinen, S. G., van Buchem, M. A., van der Weerd, L., & Webb, A. G.
- Affiliations
- Leiden University Medical Center (NL)
- Corresponding author
- Webb, Andrew G.
- Venue
- NMR in Biomedicine
- Publisher
- Wiley
- Published
- 2010-10-19
- Volume
- 24
- Issue
- 4
- Pages
- 351-357
- ISSN
- 0952-3480 (ISSN-L)
- 1099-1492
- OpenAlex
- W1969878863
- Cited by
- 39
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 4 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NMR in Biomedicine (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Advanced NMR Techniques and Applications
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Atomic and Subatomic Physics Research
- Keywords
- microcoils, self-resonant coils, high-field MRI, ex vivo brain tissue, Alzheimer's disease, iron staining, amyloid-beta deposition, co-registration, signal-to-noise ratio, birdcage coil
- MeSH terms
- Alzheimer Disease, Brain, Calibration, Humans, Magnetic Resonance Imaging, Radio Waves, Echo-Planar Imaging
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