MRI and histological analysis of beta-amyloid plaques in both human Alzheimer’s disease and APP/PS1 transgenic mice.
Open accessAbstract
PURPOSE: To investigate the relationship between MR image contrast associated with beta-amyloid (Abeta) plaques and their histology and compare the histopathological basis of image contrast and the relaxation mechanism associated with Abeta plaques in human Alzheimer's disease (AD) and transgenic APP/PS1 mouse tissues. MATERIALS AND METHODS: With the aid of the previously developed histological coil, T(2) (*)-weighted images and R(2) (*) parametric maps were directly compared with histology stains acquired from the same set of Alzheimer's and APP/PS1 tissue slices. RESULTS: The electron microscopy and histology images revealed significant differences in plaque morphology and associated iron concentration between AD and transgenic APP/PS1 mice tissue samples. For AD tissues, T(2) (*) contrast of Abeta-plaques was directly associated with the gradation of iron concentration. Plaques with significantly less iron load in the APP/PS1 animal tissues are equally conspicuous as the human plaques in the MR images. CONCLUSION: These data suggest a duality in the relaxation mechanism where both high focal iron concentration and highly compact fibrillar beta-amyloid masses cause rapid proton transverse magnetization decay. For human tissues, the former mechanism is likely the dominant source of R(2) (*) relaxation; for APP/PS1 animals, the latter is likely the major cause of increased transverse proton relaxation rate in Abeta plaques. The data presented are essential for understanding the histopathological underpinning of MRI measurement associated with Abeta plaques in humans and animals.
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The plaques showed hypointensity in MRI images and increased with age in both cortex and hippocampus regions, consistent with previous findings.
“The plaques showed hypointensity in MRI images and increased with age in both cortex and hippocampus regions, which is consistent with several previous findings (Higuchi et al., 2005; Meadowcroft et al., 2009).”
From Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging (2022) · cites this paper as Meadowcroft et al., 2009
The Results (page unavailable) identify hypointense MRI spots as Aβ plaques in APP/PS1 mouse cortex and report plaques in the neocortex and hippocampus on histological staining. The Discussion (page unavailable) says mouse plaques are believed to grow throughout life, but the paper does not establish an age-related increase in both regions; it also says the smaller hippocampal plaques described in the Results were not visible on MRI. (LLM, conf=0.86)
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Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging
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“The plaques showed hypointensity in MRI images and increased with age in both cortex and hippocampus regions, which is consistent with several previous findings (Higuchi et al., 2005; Meadowcroft et al., 2009).”
Result
- Authors
- Meadowcroft, M. D., Connor, J. R., Smith, M. B., & Yang, Q. X.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Yang, Qing X.
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2009-04-22
- Volume
- 29
- Issue
- 5
- Pages
- 997-1007
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- PMC
- PMC2723054
- OpenAlex
- W2085440855
- Cited by
- 176
- References
- 56
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 14 · 2021: 8 · 2020: 18 · 2019: 10 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 8 · 2014: 10 · 2013: 11 · 2012: 9
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pennsylvania Department of Health
- University of Minnesota
- National Institutes of Health
- National Institute on Aging (R01AG027771, R01 AG)
- National Institute of Biomedical Imaging and Bioengineering (R01EB000459, 5R01EB000459-4)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid plaques, Alzheimer's disease, APP/PS1 mice, MRI contrast, T2-weighted imaging, R2* relaxation, iron content, plaque morphology, histopathology
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Humans, Magnetic Resonance Imaging, Mice, Transgenic, Receptors, Cell Surface, Sensitivity and Specificity, Species Specificity, Reproducibility of Results, Amyloid beta-Protein Precursor, Mice, Plaque, Amyloid, Protease Nexins
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