A review of β-amyloid neuroimaging in Alzheimer's disease

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657 · see citing works

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease

Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works

Global prevalence of dementia: a Delphi consensus study

Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336 · see citing works

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works

Alzheimer's disease

Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., & Jones, E. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61349-9 · Cited by 2,336 · see citing works

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

Villemagne, V. L., Burnham, S., Bourgeat, P., Brown, B., Ellis, K. A., Salvado, O., Szoeke, C., Macaulay, S. L., Martins, R., Maruff, P., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70044-9 · Cited by 2,279 · see citing works

The clinical use of structural MRI in Alzheimer disease

Frisoni, G. B., Fox, N. C., Jack, C. R., Scheltens, P., & Thompson, P. M. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.215 · Cited by 2,113 · see citing works

Alzheimer’s Dementia

Melnick, V. L., & Dubler, N. N. (1985) · Contemporary Issues in Biomedicine, Ethics, and Society · doi:10.1007/978-1-4612-5174-3 · Cited by 1,986 · see citing works

Alzheimer's Disease and the Amyloid-β Peptide

Murphy, M. P., & LeVine, H. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1221 · Cited by 1,750 · see citing works

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038 · see citing works

Imaging iron stores in the brain using magnetic resonance imaging

Haacke, E. M., Cheng, N. Y. C., House, M. J., Liu, Q., Neelavalli, J., Ogg, R. J., Khan, A., Ayaz, M., Kirsch, W., & Obenaus, A. (2005) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2004.10.001 · Cited by 995 · see citing works

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

Rowe, C. C., Ellis, K. A., Rimajova, M., Bourgeat, P., Pike, K. E., Jones, G., Fripp, J., Tochon-Danguy, H., Morandeau, L., O'Keefe, G., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.007 · Cited by 986 · see citing works

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

Jack, C. R., Lowe, V. J., Senjem, M. L., Weigand, S. D., Kemp, B. J., Shiung, M. M., Knopman, D. S., Boeve, B. F., Klunk, W. E., Mathis, C. A., et al. (2008) · Brain · doi:10.1093/brain/awm336 · Cited by 958 · see citing works

2011 Alzheimer's disease facts and figures

Alzheimer's Association (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.02.004 · Cited by 914 · see citing works

Neuropathology of Alzheimer's Disease

Perl, D. P. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20157 · Cited by 825 · see citing works

The role of microglia in amyloid clearance from the AD brain

Lee, C. Y. D., & Landreth, G. E. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0433-4 · Cited by 701 · see citing works

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

Agostinho, P., A. Cunha, R., & Oliveira, C. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210793176572 · Cited by 685 · cited 8× · see citing works

Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden

Hedden, T., Van Dijk, K. R. A., Becker, J. A., Mehta, A., Sperling, R. A., Johnson, K. A., & Buckner, R. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3189-09.2009 · Cited by 598 · see citing works

Functional Alterations in Memory Networks in Early Alzheimer’s Disease

Sperling, R. A., Dickerson, B. C., Pihlajamaki, M. M., Vannini, P., LaViolette, P. S., Vitolo, O. V., Hedden, T., Becker, J. A., Rentz, D. M., Selkoe, D. J., et al. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8109-7 · Cited by 587 · see citing works

Synaptic degeneration in Alzheimer's disease

Arendt, T. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0536-x · Cited by 517 · see citing works

Subjective cognitive complaints and amyloid burden in cognitively normal older individuals

Amariglio, R. E., Becker, J. A., Carmasin, J., Wadsworth, L. P., Lorius, N., Sullivan, C., Maye, J. E., Gidicsin, C., Pepin, L. C., Sperling, R. A., et al. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.08.011 · Cited by 472 · see citing works

National estimates of the prevalence of Alzheimer's disease in the United States

Brookmeyer, R., Evans, D. A., Hebert, L. E., Langa, K. M., Heeringa, S. G., Plassman, B. L., & Kukull, W. A. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.11.007 · Cited by 402 · see citing works

Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance

Ewers, M., Walsh, C., Trojanowski, J. Q., Shaw, L. M. J., Petersen, R. C., Jack, C. R., Feldman, H., Bokde, A. L. W., Alexander, G. E., Scheltens, P., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.10.019 · Cited by 397 · see citing works

Diffusion Tensor Imaging

Jones, D. K., & Leemans, A. (2010) · Methods in molecular biology · doi:10.1007/978-1-61737-992-5_6 · Cited by 391 · see citing works

Binding of the Positron Emission Tomography Tracer Pittsburgh Compound-B Reflects the Amount of Amyloid-β in Alzheimer's Disease Brain But Not in Transgenic Mouse Brain

Klunk, W. E., Lopresti, B. J., Ikonomović, M. D., Lefterov, I. M., Koldamova, R. P., Abrahamson, E. E., Debnath, M. L., Holt, D. P., Huang, G.-F., Shao, L., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2990-05.2005 · Cited by 376 · see citing works

Metals and amyloid‐β in Alzheimer's disease

Maynard, C. J., Bush, A. I., Masters, C. L., Cappai, R., & Li, Q. (2005) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2005.00434.x · Cited by 353 · see citing works

Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia

Ewers, M., Sperling, R. A., Klunk, W. E., Weiner, M. W., & Hampel, H. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.05.005 · Cited by 345 · see citing works

Brain ferritin iron may influence age- and gender-related risks of neurodegeneration

Bartzokis, G., Tishler, T. A., Lu, P. H., Villablanca, P. J., Altshuler, L. L., Carter, M., Huang, D., Edwards, N. J., & Mintz, J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.02.005 · Cited by 343 · see citing works

19F and 1H MRI detection of amyloid β plaques in vivo

Higuchi, M., Iwata, N., Matsuba, Y., Sato, K., Sasamoto, K., & Saido, T. C. (2005) · Nature Neuroscience · doi:10.1038/nn1422 · Cited by 339 · see citing works

Transgenic mouse models of Alzheimer’s disease.

Elder, G. A., Gama Sosa, M. A., & De Gasperi, R. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20159 · Cited by 336 · see citing works

Causative and susceptibility genes for Alzheimer’s disease: a review

Rocchi, A., Pellegrini, S., Siciliano, G., & Murri, L. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00067-4 · Cited by 319 · see citing works

Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

Maeda, J., Ji, B., Irie, T., Tomiyama, T., Maruyama, M., Okauchi, T., Staufenbiel, M., Iwata, N., Ono, M., Saido, T. C., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0673-07.2007 · Cited by 300 · see citing works

Discriminative analysis of early Alzheimer's disease using multi-modal imaging and multi-level characterization with multi-classifier (M3)

Dai, Z., Yan, C., Wang, Z., Wang, J., Xia, M., Li, K., & Yong He, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.003 · Cited by 291 · see citing works

Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study

Schrag, M., McAuley, G. A., Pomakian, J., Jiffry, A., Tung, S., Mueller, C., Vinters, H. V., Haacke, E. M., Holshouser, B. A., Kido, D. K., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0615-z · Cited by 287 · see citing works

Pre-Clinical Detection of Alzheimer's Disease Using FDG-PET, with or without Amyloid Imaging

Mosconi, L., Berti, V., Glodzik, L., Pupi, A., Santi, S. D., & de Leon, M. J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091504 · Cited by 279 · see citing works

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

Wadghiri, Y. Z., Sigurdsson, E. M., Sadowski, M. J., Elliott, J. I., Li, Y., Scholtzova, H., Tang, C. Y., Aguinaldo, G., Pappolla, M. A., Duff, K., et al. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10529 · Cited by 273 · see citing works

Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

Bush, A. I. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15208 · Cited by 267 · see citing works

Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

Minati, L., Edginton, T. L., Bruzzone, M. G., & Giaccone, G. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317508328602 · Cited by 266 · see citing works

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

Reddy, P. H. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.042 · Cited by 264 · see citing works

Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease: A Cross-sectional Imaging Study

Dean, D. C., Jerskey, B. A., Chen, K., Protas, H., Thiyyagura, P., Roontiva, A., O'Muircheartaigh, J., Dirks, H., Waskiewicz, N., Lehman, K., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.4544 · Cited by 263 · see citing works

Role of structural MRI in Alzheimer's disease

Vemuri, P., & Jack, C. R. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt47 · Cited by 246 · see citing works

Diffusion tensor imaging in Alzheimer’s disease and mild cognitive impairment.

Stebbins, G. T., & Murphy, C. M. (2009) · Behavioural Neurology · doi:10.1155/2009/915041 · Cited by 245 · see citing works

Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects

Müller, W. E., Eckert, A., Kurz, C., Eckert, G. P., & Leuner, K. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8141-5 · Cited by 243 · see citing works

Clinical amyloid imaging in Alzheimer's disease

Herholz, K., & Ebmeier, K. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70123-5 · Cited by 240 · see citing works

Detection of neuritic plaques in Alzheimer’s disease by magnetic resonance microscopy

Benveniste, H., Einstein, G., Kim, K. R., Hulette, C., & Johnson, G. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14079 · Cited by 238 · see citing works

Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

Masters, C. L., Cappai, R., Barnham, K. J., & Villemagne, V. L. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03989.x · Cited by 237 · see citing works

Molecular Targeting of Alzheimer's Amyloid Plaques for Contrast-Enhanced Magnetic Resonance Imaging

Poduslo, J. F., Wengenack, T. M., Curran, G. L., Wısnıewskı, T., Sigurdsson, E. M., Macura, S. I., Borowski, B., & Jack, C. R. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0550 · Cited by 216 · see citing works

Oxidatively modified proteins in Alzheimer’s disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

Sultana, R., Perluigi, M., & Butterfield, D. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0517-0 · Cited by 215 · see citing works

Diffusion tensor imaging in Alzheimer's disease and mild cognitive impairment.

Stebbins, G. T., & Murphy, C. M. (2009) · PubMed · doi:10.3233/ben-2009-0234 · Cited by 210 · see citing works

Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy

Marjańska, M., Curran, G. L., Wengenack, T. M., Henry, P., Bliss, R., Poduslo, J. F., Jack, C. R., Uǧurbil, K., & Garwood, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505513102 · Cited by 200 · see citing works

Large-Scale Functional Brain Network Abnormalities in Alzheimer’s Disease: Insights from Functional Neuroimaging

Dickerson, B. C., & Sperling, R. A. (2009) · Behavioural Neurology · doi:10.1155/2009/610392 · Cited by 197 · see citing works

In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent

Jack, C. R., Garwood, M., Wengenack, T. M., Borowski, B., Curran, G. L., Lin, J., Adriany, G., Gröhn, O. H. J., Grimm, R. C., & Poduslo, J. F. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20266 · Cited by 196 · see citing works

Pathways by Which Aβ Facilitates Tau Pathology

Blurton-Jones, M. M., & LaFerla, F. M. (2006) · Current Alzheimer Research · doi:10.2174/156720506779025242 · Cited by 195 · see citing works

Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo.

Rabinovici, G. D., & Jagust, W. J. (2009) · PubMed Central · doi:10.3233/ben-2009-0232 · Cited by 194 · see citing works

Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases

Bartzokis, G., Tishler, T. A., Shin, I., Lu, P. H., & Cummings, J. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.019 · Cited by 184 · see citing works

Amyloid Imaging in Aging and Dementia: Testing the Amyloid HypothesisIn Vivo

Rabinovici, G. D., & Jagust, W. J. (2009) · Behavioural Neurology · doi:10.1155/2009/609839 · Cited by 183 · see citing works

MRI and histological analysis of beta-amyloid plaques in both human Alzheimer’s disease and APP/PS1 transgenic mice.

Meadowcroft, M. D., Connor, J. R., Smith, M. B., & Yang, Q. X. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21731 · Cited by 176 · see citing works

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

Zahs, K. R., & Ashe, K. H. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.05.004 · Cited by 173 · see citing works

Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging.

Dickerson, B. C., & Sperling, R. A. (2009) · PubMed · doi:10.3233/ben-2009-0227 · Cited by 167 · see citing works

The Role of Tau Phosphorylation in the Pathogenesis of Alzheimers Disease

Mi, K., & Johnson, G. V. W. (2006) · Current Alzheimer Research · doi:10.2174/156720506779025279 · Cited by 166 · see citing works

Quinoline‐n‐butylcyanoacrylate‐based nanoparticles for brain targeting for the diagnosis of Alzheimer's disease

Kulkarni, P. V., Roney, C. A., Antich, P. P., Bonte, F. J., Raghu, A. V., & Aminabhavi, T. M. (2009) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.59 · Cited by 159 · see citing works

Larger temporal volume in elderly with high versus low beta-amyloid deposition

Chételat, G., Villemagne, V. L., Pike, K. E., Baron, J.-C., Bourgeat, P., Jones, G., Faux, N. G., Ellis, K. A., Salvado, O., Szoeke, C., et al. (2010) · Brain · doi:10.1093/brain/awq187 · Cited by 159 · see citing works

Not quite PIB-positive, not quite PIB-negative: Slight PIB elevations in elderly normal control subjects are biologically relevant

Mormino, E. C., Brandel, M. G., Madison, C. M., Rabinovici, G. D., Marks, S., Baker, S. L., & Jagust, W. J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.098 · Cited by 158 · see citing works

Metal and Inflammatory Targets for Alzheimers Disease

Rogers, J. T., & Lahiri, D. K. (2004) · Current Drug Targets · doi:10.2174/1389450043345272 · Cited by 149 · see citing works

<i>In Vivo</i>Magnetic Resonance Microimaging of Individual Amyloid Plaques in Alzheimer's Transgenic Mice

Jack, C. R., Wengenack, T. M., Reyes, D. A., Garwood, M., Curran, G. L., Borowski, B. J., Lin, J., Preboske, G. M., Holasek, S. S., Adriany, G., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2588-05.2005 · Cited by 148 · see citing works

Aβ aggregation and possible implications in Alzheimer's disease pathogenesis

Bharadwaj, P. R., Dubey, A. K., Masters, C. L., Martins, R. N., & Macreadie, I. G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00609.x · Cited by 147 · see citing works

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

Salek, R. M., Xia, J., Innes, A. E., Sweatman, B. C., Adalbert, R., Randle, S. J., McGowan, E. M., Emson, P. C., & Griffin, J. L. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.04.001 · Cited by 146 · see citing works

Current and future uses of neuroimaging for cognitively impaired patients

Small, G. W., Bookheimer, S. Y., Thompson, P. M., Cole, G. M., Huang, S.-C., Kepe, V., & Barrio, J. R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70019-x · Cited by 142 · see citing works

Amyloid‐induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue‐culture models

Götz, J., Schild, A., Hoerndli, F. J., & Pennanen, L. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.07.013 · Cited by 141 · see citing works

Disease Tracking Markers for Alzheimer's Disease at the Prodromal (MCI) Stage

Drago, V., Babiloni, C., Bartrés‐Faz, D., Caroli, A., Bosch, B., Hensch, T., Didic, M., Klafki, H., Pievani, M., Jovicich, J., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0043 · Cited by 138 · see citing works

Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease

Vanhoutte, G., Dewachter, I., Borghgraef, P., Leuven, F. V., & der Linden, A. V. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20385 · Cited by 137 · see citing works

<i>In Vivo</i>Positron Emission Tomographic Imaging of Glial Responses to Amyloid-β and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders

Maeda, J., Zhang, M.-R., Okauchi, T., Ji, B., Ono, M., Hattori, S., Kumata, K., Iwata, N., Saido, T. C., Trojanowski, J. Q., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3076-10.2011 · Cited by 136 · see citing works

Detection of amyloid plaques targeted by USPIO-Aβ1–42 in Alzheimer's disease transgenic mice using magnetic resonance microimaging

Yang, J., Zaim Wadghiri, Y., Minh Hoang, D., Tsui, W., Sun, Y., Chung, E., Li, Y., Wang, A., de Leon, M., & Wisniewski, T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.023 · Cited by 135 · see citing works

Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease

Leskovjan, A. C., Kretlow, A., Lanzirotti, A., Barrea, R. A., Vogt, S., & Miller, L. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.073 · Cited by 134 · see citing works

PET imaging of brain with the β-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer’s disease

Toyama, H., Ye, D. G., Ichise, M., Liow, J., Cai, L., Jacobowitz, D. M., Musachio, J. L., Hong, J. S., Crescenzo, M., Tipre, D. N., et al. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1780-5 · Cited by 126 · see citing works

Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease

Leskovjan, A. C., Lanzirotti, A., & Miller, L. M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.063 · Cited by 125 · see citing works

Hybrid FMT–CT imaging of amyloid-β plaques in a murine Alzheimer's disease model

Hyde, D. E., DEKLEINE, R., MacLaurin, S. A., Miller, E. L., BROOKS, D., Krucker, T., & Ntziachristos, V. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.038 · Cited by 123 · see citing works

Histological Co-Localization of Iron in A� Plaques of PS/APP Transgenic Mice

Falangola, M. F., Lee, P., Nixon, R. A., Duff, K., & Helpern, J. A. (2005) · Neurochemical Research · doi:10.1007/s11064-004-2442-x · Cited by 122 · see citing works

Alzheimer's disease: diverse aspects of mitochondrial malfunctioning.

Santos, R. X., Correia, S. C., Wang, X., Perry, G. L., Smith, M. A., Moreira, P. I., & Zhu, X. (2010) · Europe PMC (PubMed Central) · Cited by 120 · see citing works

Assessing neuronal networks: Understanding Alzheimer's disease

Bokde, A. L. W., Ewers, M., & Hampel, H. J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.06.004 · Cited by 117 · see citing works

Filling the Gaps in the Aβ Cascade Hypothesis of Alzheimers Disease

Golde, T. E., Dickson, D. W., & Hutton, M. L. (2006) · Current Alzheimer Research · doi:10.2174/156720506779025189 · Cited by 115 · see citing works

Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease

Faure, A., Verret, L., Bozon, B., El Tannir El Tayara, N., Ly, M., Kober, F., Dhenain, M., Rampon, C., & Delatour, B. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.009 · Cited by 112 · see citing works

Quantitative MR Imaging in Alzheimer Disease

Ramani, A., Jensen, J. H., & Helpern, J. A. (2006) · Radiology · doi:10.1148/radiol.2411050628 · Cited by 111 · see citing works

Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models

Nicholson, R. M., Kusne, Y., Nowak, L. A., LaFerla, F. M., Reiman, E. M., & Valla, J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.084 · Cited by 107 · see citing works

APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis

Crews, L. A., Rockenstein, E. M., & Masliah, E. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0232-6 · Cited by 107 · see citing works

In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice

Delatour, B., Guégan, M., Volk, A., & Dhénain, M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.04.011 · Cited by 106 · see citing works

MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease

Helpern, J. A., Lee, P., Falangola, M. F., Dyakin, V. V., Bogart, A., Ardekani, B. A., Duff, K., Branch, C. A., Wısnıewskı, T., de Leon, M. J., et al. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20038 · Cited by 105 · see citing works

Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

von Kienlin, M., Künnecke, B., Metzger, F., Steiner, G., Richards, J. G., Ozmen, L., Jacobsen, H., & Loetscher, H. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.005 · Cited by 104 · see citing works

Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients

House, M. J., Pierre, T. G. S., Kowdley, K. V., Montine, T. J., Connor, J. R., Beard, J., Berger, J., Siddaiah, N. B., Shankland, E. G., & Jin, L. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21118 · Cited by 103 · see citing works

Age related changes in brain metabolites observed by 1H MRS in APP/PS1 mice

Öberg, J., Spenger, C., Wang, F., Andersson, A. D. R., Westman, E., Skoglund, P., Sunnemark, D., Norinder, U., Klason, T., Wahlund, L., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.002 · Cited by 103 · see citing works

Neuroimaging in Alzheimer's disease: current role in clinical practice and potential future applications

Ferreira, L. K., & Busatto, G. F. (2011) · Clinics · doi:10.1590/s1807-59322011001300003 · Cited by 102 · see citing works

Alzheimer disease: Evidence for a central pathogenic role of iron-mediated reactive oxygen species

Casadesús, G., Smith, M. A., Zhu, X., Aliev, G. M., Cash, A., Honda, K., Petersen, R. B., & Perry, G. L. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6208 · Cited by 101 · see citing works

Animal models of amyloid‐β‐related pathologies in Alzheimer’s disease

Philipson, O., Lord, A., Gumucio, A., O'Callaghan, P. W., Lannfelt, L., & Nilsson, L. N. G. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07564.x · Cited by 98 · see citing works

Mechanisms of amyloid plaque pathogenesis

Fiala, J. C. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0284-8 · Cited by 98 · see citing works

Visualization of β‐amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents

Lee, P., Falangola, M. F., Nixon, R. A., Duff, K., & Helpern, J. A. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20196 · Cited by 97 · see citing works

Natural history of Alzheimer’s disease

Honig, L. S., & Mayeux, R. P. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03351476 · Cited by 96 · see citing works

Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies

Mistur, R. L., Mosconi, L., Santi, S. D., Guzman, M., Li, Y., Tsui, W., & de Leon, M. J. (2009) · Journal of Clinical Neurology · doi:10.3988/jcn.2009.5.4.153 · Cited by 94 · see citing works

In Vivo Visualization of Senile‐Plaque‐Like Pathology in Alzheimer's Disease Patients by MR Microscopy on a 7T System

Nakada, T., Matsuzawa, H., Igarashi, H., Fujii, Y., & Kwee, I. L. (2007) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2007.00179.x · Cited by 93 · see citing works

Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease

Kuntner, C., Kesner, A., Bauer, M., Kremslehner, R., Wanek, T., Mandler, M., Karch, R., Stanek, J., Wolf, T., Müller, M., et al. (2009) · Molecular Imaging and Biology · doi:10.1007/s11307-009-0198-z · Cited by 90 · see citing works

Positron Emission Tomography Radiopharmaceuticals for Imaging Brain Beta-Amyloid

Vallabhajosula, S. (2011) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2011.02.005 · Cited by 90 · see citing works

Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging

Zhang, J., Yarowsky, P., Gordon, M. N., Carlo, G. D., Munireddy, S., van Zijl, P. C. M., & Mori, S. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10730 · Cited by 89 · see citing works

In vivo detection of amyloid β deposition using 19F magnetic resonance imaging with a 19F-containing curcumin derivative in a mouse model of Alzheimer's disease

Yanagisawa, D., Amatsubo, T., Morikawa, S., Taguchi, H., Urushitani, M., Shirai, N., Hirao, K., Shiino, A., Inubushi, T., & Tooyama, I. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.071 · Cited by 88 · see citing works

Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease

Tayara, N. E. T. E., Delatour, B., Cudennec, C. L., Guégan, M., Volk, A., & Dhénain, M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.10.013 · Cited by 85 · see citing works

Origin and reduction of motion and f0 artifacts in high resolution T2*-weighted magnetic resonance imaging: Application in Alzheimer's disease patients

Versluis, M. J., Peeters, J., van Rooden, S., van der Grond, J., van Buchem, M. A., WEBB, A. G., & van Osch, M. J. P. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.03.048 · Cited by 85 · see citing works

Bis (thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease

Fodero‐Tavoletti, M. T., Villemagne, V. L., Paterson, B. M., White, A. R., Li, Q., Camakaris, J., O'Keefe, G. J., Cappai, R., Barnham, K. J., & Donnelly, P. S. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1359 · Cited by 83 · see citing works

Novel 18F-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques in Alzheimer’s Brains

Ono, M., Cheng, Y., Kimura, H., Cui, M., Kagawa, S., Nishii, R., & Saji, H. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200057u · Cited by 83 · see citing works

High field magnetic resonance microscopy of the human hippocampus in Alzheimer's disease: quantitative imaging and correlation with iron

Antharam, V., Collingwood, J. F., Bullivant, J.-P., Davidson, M. R., Chandra, S., Mikhaylova, A., Finnegan, M. E., Batich, C., Forder, J. R., & Dobson, J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.019 · Cited by 82 · see citing works

Murine models of Alzheimer's disease and their use in developing immunotherapies

Wısnıewskı, T., & Sigurdsson, E. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.05.004 · Cited by 80 · see citing works

APP transgenic mice: their use and limitations

Balducci, C., & Forloni, G. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8141-7 · Cited by 79 · see citing works

Neurotoxicity of β-Amyloid Protein: Oligomerization, Channel Formation and Calcium Dyshomeostasis

Kawahara, M. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210793176545 · Cited by 77 · see citing works

Longitudinal assessment of Alzheimer's β‐amyloid plaque development in transgenic mice monitored by in vivo magnetic resonance microimaging

Braakman, N., Matysik, J., van Duinen, S. G., Verbeek, F. J., Schliebs, R., de Groot, H. J. M., & Alia, A. (2006) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20675 · Cited by 77 · see citing works

Voxel-based analysis of Alzheimer's disease PET imaging using a triplet of radiotracers: PIB, FDDNP, and FDG

Shin, J., Lee, S., Kim, S. J., Kim, S., Cho, S., & Kim, Y.-B. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.013 · Cited by 76 · see citing works

Role of Myo-Inositol by Magnetic Resonance Spectroscopy in Early Diagnosis of Alzheimer’s Disease in APP/PS1 Transgenic Mice

Chen, S., Wang, P., Ten, G.-J., Zhan, W., Li, M., & Zang, F. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000261646 · Cited by 76 · see citing works

Magnetic Resonance Imaging of Alzheimer's Pathology in the Brains of Living Transgenic Mice: A New Tool in Alzheimer's Disease Research

Jack, C. R., Marjańska, M., Wengenack, T. M., Reyes, D. A., Curran, G. L., Lin, J., Preboske, G. M., Poduslo, J. F., & Garwood, M. (2007) · The Neuroscientist · doi:10.1177/1073858406295610 · Cited by 76 · see citing works

Magnetic resonance imaging of Alzheimer’s disease

Lehéricy, S., Marjańska, M., Mesrob, L., Sarazin, M., & Kinkingnéhun, S. (2006) · European Radiology · doi:10.1007/s00330-006-0341-z · Cited by 74 · see citing works

Senile plaques do not induce susceptibility effects in T2*‐weighted MR microscopic images

Dhénain, M., Privat, N., Duyckaerts, C. J., & Jacobs, R. E. (2002) · NMR in Biomedicine · doi:10.1002/nbm.760 · Cited by 72 · see citing works

Synthesis and Evaluation of 11C-Labeled Imidazo[2,1-b]benzothiazoles (IBTs) as PET Tracers for Imaging β-Amyloid Plaques in Alzheimer’s Disease

Yousefi, B. H., Manook, A., Drzezga, A. E., von Reutern, B., Schwaiger, M., Wester, H., & Henriksen, G. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101129a · Cited by 72 · see citing works

In vivo measurement of plaque burden in a mouse model of Alzheimer's disease

Borthakur, A., Gur, T., Wheaton, A. J., Corbo, M. T., Trojanowski, J. Q., Lee, V. M. ‐., & Reddy, R. D. (2006) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20751 · Cited by 69 · see citing works

A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice

Sigurdsson, E. M., Wadghiri, Y. Z., Mosconi, L., Blind, J. A., Knudsen, E., Asuni, A. A., Scholtzova, H., Tsui, W. H., Li, Y., Sadowski, M. J., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.018 · Cited by 66 · see citing works

Alzheimer's disease beyond the genomic era: nuclear magnetic resonance (NMR) spectroscopy‐based metabolomics

Barba, I., Fernández-Montesinos, R., García‐Dorado, D., & Pozo, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00385.x · Cited by 63 · see citing works

Comparison of amyloid plaque contrast generated by T2‐weighted, T‐weighted, and susceptibility‐weighted imaging methods in transgenic mouse models of Alzheimer's disease

Chamberlain, R., Reyes, D. A., Curran, G. L., Marjańska, M., Wengenack, T. M., Poduslo, J. F., Garwood, M., & Jack, C. R. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21951 · Cited by 62 · see citing works

Quantitative magnetization transfer provides information complementary to grey matter atrophy in Alzheimer's disease brains

Giulietti, G., Bozzali, M., Figura, V., Spanò, B., Perri, R., Marra, C., Lacidogna, G., Giubilei, F., Caltagirone, C., & Cercignani, M. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.043 · Cited by 62 · see citing works

Advances and perspectives from genetic research: development of biological markers in Alzheimer’s disease

Zetzsche, T., Rujescu, D., Hardy, J., & Hampel, H. J. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.48 · Cited by 61 · see citing works

Quantitative analysis of amyloid plaques in a mouse model of Alzheimer’s disease by phase-contrast X-ray computed tomography

Noda-Saita, K., Yoneyama, A., Shitaka, Y., Hirai, Y., Terai, K., Wu, J., Takeda, T., Hyodo, K., Osakabe, N., Yamaguchi, T., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.036 · Cited by 58 · see citing works

Computed tomography of amyloid plaques in a mouse model of Alzheimer's disease using diffraction enhanced imaging

Connor, D. M., Benveniste, H., Dilmanian, F. A., Kritzer, M. F., Miller, L. M., & Zhong, Z. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.03.019 · Cited by 56 · see citing works

Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice

Dhénain, M., Tayara, N. E. T. E., Wu, T., Guégan, M., Volk, A., Quintana, C., & Delatour, B. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.018 · Cited by 56 · see citing works

Imaging of Alzheimer's Disease

Lee, B. C. P., Mintun, M. A., Buckner, R. L., & Morris, J. C. (2003) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2003.tb00179.x · Cited by 54 · see citing works

Quantitative MRI reveals aging‐associated T2 changes in mouse models of Alzheimer's disease

Falangola, M. F., Dyakin, V. V., Lee, P., Bogart, A., Babb, J. S., Duff, K., Nixon, R. A., & Helpern, J. A. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1163 · Cited by 53 · see citing works

Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)

Ellis, K. A., Szoeke, C. E. I., Bush, A. I., Darby, D., Graham, P. L., Lautenschlager, N. T., Macaulay, S. L., Martins, R. N., Maruff, P. T., Masters, C. L., et al. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213001956 · Cited by 53 · see citing works

Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease

Dubois, A., Hérard, A., Delatour, B., Hantraye, P., Bonvento, G., Dhénain, M., & Delzescaux, T. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.02.074 · Cited by 52 · see citing works

1.4T study of proton magnetic relaxation rates, iron concentrations, and plaque burden in Alzheimer's disease and control postmortem brain tissue

House, M. J., Pierre, T. G. S., & McLean, C. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21586 · Cited by 51 · see citing works

Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging

Woodhouse, A., Vickers, J. C., Adlard, P. A., & Dickson, T. C. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.09.003 · Cited by 50 · see citing works

Visualizing Pathology Deposits in the Living Brain of Patients with Alzheimer's Disease

Kepe, V., Huang, S., Small, G. W., Satyamurthy, N., & Barrio, J. R. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)12010-8 · Cited by 49 · see citing works

Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease

Badea, A., Johnson, G. A., & Jankowsky, J. L. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.070 · Cited by 47 · see citing works

Mouse models in neurological disorders: Applications of non-invasive imaging

Waerzeggers, Y., Monfared, P., Viel, T., Winkeler, A., & Jacobs, A. H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.04.009 · Cited by 47 · see citing works

The Role of MRI and PET/SPECT in Alzheimers Disease

Coimbra, A., Williams, D., & Hostetler, E. D. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606776743075 · Cited by 43 · see citing works

Regional differences in MRI detection of amyloid plaques in AD transgenic mouse brain

Wengenack, T. M., Reyes, D. A., Curran, G. L., Borowski, B. J., Lin, J., Preboske, G. M., Holasek, S. S., Gilles, E. J., Chamberlain, R., Marjanska, M., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.033 · Cited by 41 · see citing works

[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-Aβ antibody treatment

Teng, E., Kepe, V., Frautschy, S. A., Liu, J., Satyamurthy, N., Yang, F., Chen, P., Cole, G. B., Jones, M. R., Huang, S., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.003 · Cited by 41 · see citing works

Functional implications of hippocampal degeneration in early Alzheimer’s disease: a combined DTI and PET study

Yakushev, I. Y., Schreckenberger, M., Müller, M. J., Schermuly, I., Cumming, P. D., Stoeter, P., Gerhard, A., & Fellgiebel, A. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1882-1 · Cited by 40 · see citing works

High‐field MRI of single histological slices using an inductively coupled, self‐resonant microcoil: application to <i>ex vivo</i> samples of patients with Alzheimer's disease

Nabuurs, R. J. A., Hegeman, I., Natté, R., van Duinen, S. G., van Buchem, M. A., van der Weerd, L., & Webb, A. G. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1598 · Cited by 39 · see citing works

The Role of Quantitative Structural Imaging in the Early Diagnosis of Alzheimer's DiseaseQ4

Głodzik-Sobańska, L., Rusinek, H., Mosconi, L., Li, Y., Zhan, J., Santi, S. D., Convit, A. J., Rich, K. E., Bryś, M., & de Leon, M. J. (2005) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2005.09.004 · Cited by 39 · see citing works

MR Microimaging of amyloid plaques in Alzheimer’s disease transgenic mice

Wengenack, T. M., Jack, C. R., Garwood, M., & Poduslo, J. F. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-007-0706-9 · Cited by 38 · see citing works

Animal Models for Alzheimer’s Disease and Frontotemporal Dementia: A Perspective

Götz, J., & Götz, N. N. (2009) · ASN NEURO · doi:10.1042/an20090042 · Cited by 37 · see citing works

Age- and transgene-related changes in regional cerebral metabolism in PSAPP mice

Valla, J., Schneider, L. E., & Reiman, E. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.097 · Cited by 36 · see citing works

Gradient‐echo and CRAZED imaging for minute detection of Alzheimer plaques in an APPV717I × ADAM10‐dn mouse model

Faber, C., Zahneisen, B., Tippmann, F., Schroeder, A., & Fahrenholz, F. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21201 · Cited by 36 · see citing works

Dementia Update 2003

Morris, J. C. (2003) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200310000-00010 · Cited by 36 · see citing works

Redox-active metals in neurological disorders

Levine, S. M., Connor, J. R., & Schipper, H. M. (2004) · Cited by 35 · see citing works

Animal Models of Neurodegenerative Disease: Insights from In vivo Imaging Studies

Strome, E. M., & Doudet, D. J. (2007) · Molecular Imaging and Biology · doi:10.1007/s11307-007-0093-4 · Cited by 35 · see citing works

Visualization of Brain Amyloid and Microglial Activation in Mouse Models of Alzheimers Disease

Higuchi, M. (2009) · Current Alzheimer Research · doi:10.2174/156720509787602906 · Cited by 34 · see citing works

Anatomical and Functional Phenotyping of Mice Models of Alzheimer's Disease by MR Microscopy

Benveniste, H., Ma, Y., Dhawan, J., Gifford, A. J., Smith, S. D. B., Feinstein, I., Du, C., Grant, S. C., & Hof, P. R. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.006 · Cited by 34 · see citing works

FDG autoradiography reveals developmental and pathological effects of mutant amyloid in PDAPP transgenic mice

Valla, J., Gonzalez-Lima, F., & Reiman, E. M. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.02.003 · Cited by 34 · see citing works

Transverse relaxation time reflects brain amyloidosis in young APP/PS1 transgenic mice

Tayara, N. E. T. E., Volk, A., Dhénain, M., & Delatour, B. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21266 · Cited by 33 · see citing works

Effects of Image Resolution on Autoradiographic Measurements of Posterior Cingulate Activity in PDAPP Mice: Implications for Functional Brain Imaging Studies of Transgenic Mouse Models of Alzheimer's Disease

Valla, J. E., Chen, K., Berndt, J. D., Gonzalez-Lima, F., Cherry, S. R., Games, D., & Reiman, E. M. (2002) · NeuroImage · doi:10.1006/nimg.2002.1080 · Cited by 33 · see citing works

Amyloid Imaging in Alzheimer’s Disease and Other Dementias

Fodero‐Tavoletti, M. T., Cappai, R., McLean, C., Pike, K. E., Adlard, P. A., Cowie, T., Connor, A. R., Masters, C. L., Rowe, C. C., & Villemagne, V. L. (2009) · Brain Imaging and Behavior · doi:10.1007/s11682-009-9067-2 · Cited by 33 · see citing works

Analysis of serial magnetic resonance images of mouse brains using image registration

Maheswaran, S., Barjat, H., Bate, S. T., Aljabar, P., Hill, D., Tilling, L. C., Upton, N., James, M. F., Hajnal, J. V., & Rueckert, D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.016 · Cited by 30 · see citing works

Different Patterns of Fornix Damage in Idiopathic Normal Pressure Hydrocephalus and Alzheimer Disease

Hattori, T., Sato, R., Aoki, S., Yuasa, T., & Mizusawa, H. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2780 · Cited by 30 · see citing works

Detection of Aβ Plaques by a Novel Specific MRI Probe Precursor CR‐BSA‐(Gd‐DTPA)n in APP/PS1 Transgenic Mice

Li, S., He, H., Cui, W., Gu, B., Li, J., Qi, Z., Zhou, G., Liang, C., & Feng, X. (2010) · The Anatomical Record · doi:10.1002/ar.21209 · Cited by 30 · see citing works

Amyloid imaging

Villemagne, V. L., & Rowe, C. C. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211000895 · Cited by 30 · see citing works

Clinical aspects of Alzheimer’s disease

Bianchetti, A., & Trabucchi, M. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03351480 · Cited by 29 · see citing works

Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy for Detection of Early Alzheimer's Disease

Westman, E., Wahlund, L., Foy, C., Poppe, M., Cooper, A., Murphy, D., Spenger, C., Lovestone, S., & Simmons, A. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0028 · Cited by 28 · see citing works

Automated Detection of Amyloid-β-Related Cortical and Subcortical Signal Changes in a Transgenic Model of Alzheimer's Disease using High-Field MRI

Teipel, S. J., Kaza, E., Hadlich, S., Bauer, A. J., Brüning, T., Plath, A.-S., Krohn, M., Scheffler, K., Walker, L. C., Lotze, M., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101035 · Cited by 28 · see citing works

Characterisation of the binding of amyloid imaging tracers to rodent Aβ fibrils and rodent-human Aβ co-polymers

Ye, L., Morgenstern, J. L., Lamb, J. R., & Lockhart, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.06.126 · Cited by 27 · see citing works

Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease

Roney, C. A., Arora, V., Kulkarni, P. V., Antich, P. P., & Bonte, F. J. (2009) · International Journal of Alzheimer s Disease · doi:10.4061/2009/481031 · Cited by 27 · see citing works

Magnetic Resonance Imaging of Amyloid Plaques in Transgenic Mouse Models of Alzheimers Disease

Chamberlain, R., M. Wengenack, T., F. Poduslo, J., Garwood, M., & R. Jack, C. (2011) · Current Medical Imaging Reviews · doi:10.2174/157340511794653522 · Cited by 26 · cited 3× · see citing works

The two faces of Alzheimer's disease

van Gool, W. A., & Eikelenboom, P. (2000) · Journal of Neurology · doi:10.1007/s004150070147 · Cited by 26 · see citing works

Alzheimer’s disease

Reiman, E. M., & Caselli, R. J. (1999) · Maturitas · doi:10.1016/s0378-5122(98)00110-8 · Cited by 24 · see citing works

Imaging the Earliest Stages of Alzheimers Disease

Wu, W. E., & Small, S. A. (2006) · Current Alzheimer Research · doi:10.2174/156720506779025161 · Cited by 23 · see citing works

Unveiling Molecular Events in the Brain by Noninvasive Imaging

Klohs, J., & Rudin, M. (2011) · The Neuroscientist · doi:10.1177/1073858410383433 · Cited by 22 · see citing works

Reduction of hippocampal N‐acetyl aspartate level in aged APPSwe/PS1dE9 transgenic mice is associated with degeneration of CA3 pyramidal neurons

Xu, W., Zhan, Y., Huang, W., Wang, X., Zhang, S., & Lei, H. C. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22479 · Cited by 21 · see citing works

Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer’s disease

Yakushev, I. Y., Gerhard, A., Müller, M. J., Lorscheider, M., Buchholz, H., Schermuly, I., Weibrich, C., Hammers, A., Stoeter, P., Schreckenberger, M., et al. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0302-4 · Cited by 21 · see citing works

In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models

Higuchi, M., Maeda, J., Ji, B., Maruyama, M., Okauchi, T., Tokunaga, M., Ono, M., & Suhara, T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.01.003 · Cited by 20 · see citing works

Histochemical visualization and diffusion MRI at 7 Tesla in the TgCRND8 transgenic model of Alzheimer’s disease

Thiessen, J. D., Glazner, K. A. C., Nafez, S., Schellenberg, A. E., Buist, R. J., Martin, M., & Albensi, B. C. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0271-z · Cited by 20 · see citing works

Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology

Falangola, M. F., Ardekani, B. A., Lee, P., Babb, J. S., Bogart, A., Dyakin, V. V., Nixon, R. A., Duff, K., & Helpern, J. A. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.012 · Cited by 20 · see citing works

Imaging the Alzheimer Brain

Ashford, J. W., Salehi, A., Furst, A. J., Bayley, P. J., Frisoni, G. B., Jack, C. R., Sabri, O., Adamson, M. M., Coburn, K. L., Olichney, J., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0073 · Cited by 19 · see citing works

Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI

Brickman, A. M., Small, S. A., & Fleisher, A. (2009) · Behavioural Neurology · doi:10.1155/2009/246892 · Cited by 18 · see citing works

Resting‐State Glucose Metabolism Level Is Associated with the Regional Pattern of Amyloid Pathology in Alzheimer′s Disease

Shin, J., Tsui, W., Li, Y., Lee, S., Kim, S. J., Cho, S., Kim, Y.-B., & de Leon, M. J. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/759780 · Cited by 16 · see citing works

Pinpointing synaptic loss caused by Alzheimer's disease with fMRI.

Brickman, A. M., Small, S. A., & Fleisher, A. (2009) · PubMed · doi:10.3233/ben-2009-0240 · Cited by 14 · see citing works

Prospects for Early Detection of Alzheimers Disease from Serial MR Images in Transgenic Mouse Models

Muskulus, M., Scheenstra, A. E. H., Braakman, N., Dijkstra, J., Lunel, S. M. V., Alia, A., de Groot, H. J. M., & Reiber, J. H. C. (2009) · Current Alzheimer Research · doi:10.2174/156720509790147089 · Cited by 14 · see citing works

The Contribution of Small Animal Positron Emission Tomography to the Neurosciences - A Critical Evaluation

Nikolaus, S., Beu, M., Wirrwar, A., Vosberg, H., Müller, H., & Larisch, R. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.2.131 · Cited by 13 · see citing works

Neuroimaging in Alzheimer's Disease

Albert, M. S., & Lafleche, G. (1991) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30317-4 · Cited by 9 · see citing works

Intrauterine hyperexposure to dexamethasone of the common marmoset monkey revealed normal cerebral metabolite concentrations in adulthood as assessed by quantitative proton magnetic resonance spectroscopy in vivo

Michaelis, T., Abaei, A., Boretius, S., Tammer, R., Frahm, J., Schlumbohm, C., & Fuchs, E. (2009) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.2009.00342.x · Cited by 8 · see citing works

The dynamic marker hypothesis of Alzheimer's disease and its implications for clinical imaging.

Cavedo, E., & Frisoni, G. B. (2011) · PubMed · Cited by 6 · see citing works

Quantitative MR Imaging

Vandermeulen, D., Maes, F., & Leemput, K. V. (2001) · Medical radiology · doi:10.1007/978-3-642-56662-2_4 · Cited by 5 · see citing works

Recent Advances in Visualizing Alzheimer's Plaques by Magnetic Reso- nance Imaging

Braakman, N., van Buchem, M., Schliebs, R., de Groot, H. D., & Alia, A. (2009) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/157340509787354741 · Cited by 5 · see citing works

Probing Cerebrovascular Alterations in Alzheimers Disease Using MRI: From Transgenic Models to Patients

Beckmann, N. (2011) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/157340511794653531 · Cited by 5 · see citing works

Applications of Chemical Shift Imaging for AD

Scott, C. J. M., Szilagyi, G. M., Chavez, S., Ganda, A., & Black, S. E. (2011) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/157340511794653513 · Cited by 2 · see citing works

Stimulated Emission Depletion Microscopy

Blom, H., & Widengren, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00653 · Cited by 344 · see citing works

Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions

Dey, A., Bhattacharya, R., Mukherjee, A., & Pandey, D. K. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.005 · Cited by 232 · see citing works

The Role of Oxidative Damage in the Pathogenesis and Progression of Alzheimer’s Disease and Vascular Dementia

Luca, M., Luca, A., & Calandra, C. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/504678 · Cited by 177 · see citing works

Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content

Bouhrara, M., Reiter, D. A., Bergeron, C. M., Zukley, L. M., Ferrucci, L., Resnick, S. M., & Spencer, R. G. S. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.03.007 · Cited by 164 · see citing works

Aβ plaque-selective NIR fluorescence probe to differentiate Alzheimer's disease from tauopathies

Rajasekhar, K., Narayanaswamy, N., Murugan, N. A., Viccaro, K., Lee, H., Shah, K., & Govindaraju, T. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.06.030 · Cited by 99 · see citing works

Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease

Wu, L., Xian, X., Xu, G., Tan, Z., Dong, F., Zhang, M., & Zhang, F. (2022) · Mediators of Inflammation · doi:10.1155/2022/7924199 · Cited by 85 · see citing works

Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s Disease

Canchi, S., Raao, B., Masliah, D., Rosenthal, S. B., Šášik, R., Fisch, K. M., Jager, P. L. D., Bennett, D. A., & Rissman, R. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.073 · Cited by 81 · see citing works

Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway

Xiong, R., Wang, X., Wu, J., Tang, Y., Qiu, W., Shen, X., Teng, J., Pan, R., Zhao, Y., Yu, L., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112548 · Cited by 80 · see citing works

Synaptic vesicle protein 2A as a potential biomarker in synaptopathies

Heurling, K., Ashton, N. J., Leuzy, A., Zimmer, E. R., Blennow, K., Zetterberg, H., Eriksson, J., Lubberink, M., & Schöll, M. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.02.001 · Cited by 77 · see citing works

Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line

Cui, B., Zhang, S., Wang, Y., & Guo, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.053 · Cited by 75 · see citing works

Safety and efficacy of lecanemab for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials

Qiao, Y., Chi, Y., Zhang, Q., & Ma, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1169499 · Cited by 74 · see citing works

Neuroimaging correlates of cognitive impairment and dementia in Parkinson's disease

Mak, E., Su, L., Williams, G. B., & O'Brien, J. T. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.05.013 · Cited by 61 · see citing works

Analysis of RNA from Alzheimer’s Disease Post-mortem Brain Tissues

Clément, C., Hill, J. M., Dua, P., Culicchia, F., & Lukiw, W. J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9105-6 · Cited by 60 · see citing works

Hypoxia and GABA shunt activation in the pathogenesis of Alzheimer's disease

Salminen, A., Jouhten, P., Sarajärvi, T., Haapasalo, A., & Hiltunen, M. O. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.11.005 · Cited by 54 · see citing works

Synthesis and evaluation of benzothiazole-triazole and benzothiadiazole-triazole scaffolds as potential molecular probes for amyloid-β aggregation

Dyrager, C., Vieira, R. P., Nyström, S., Nilsson, K. P. R., & Storr, T. (2017) · New Journal of Chemistry · doi:10.1039/c6nj01703g · Cited by 53 · see citing works

Evaluation of Functional Decline in Alzheimer’s Dementia Using 3D Deep Learning and Group ICA for rs-fMRI Measurements

Qureshi, M. N. I., Ryu, S., Song, J., Lee, K. H., & Lee, B. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00008 · Cited by 53 · see citing works

Strategies for the Molecular Imaging of Amyloid and the Value of a Multimodal Approach

Kaur, A., New, E. J., & Sunde, M. (2020) · ACS Sensors · doi:10.1021/acssensors.0c01101 · Cited by 47 · see citing works

Optical Nanosensor for Intracellular and Intracranial Detection of Amyloid-Beta

Antman‐Passig, M., Wong, E., Frost, G. R., Cupo, C., Shah, J., Agustinus, A. S., Chen, Z., Mancinelli, C. D., Kamel, M., Li, T., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c00054 · Cited by 46 · see citing works

Genome‐wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology

Nho, K. T., Nudelman, K. N. H., Allen, M., Hodges, A., Kim, S., Risacher, S. L., Apostolova, L. G., Lin, K., Lunnon, K., Wang, X., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12092 · Cited by 46 · see citing works

Global Trends in Alzheimer Disease Clinical Development: Increasing the Probability of Success

Sugino, H., Watanabe, A., Amada, N., Yamamoto, M., Ohgi, Y., Kostic, D., & Sanchez, R. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.07.006 · Cited by 45 · see citing works

Amyloid Imaging: Poised for Integration into Medical Practice

Anand, K., & Sabbagh, M. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0474-y · Cited by 39 · see citing works

18F-labeled radiopharmaceuticals for the molecular neuroimaging of amyloid plaques in Alzheimer's disease.

Filippi, L., Chiaravalloti, A., Bagni, O., & Schillaci, O. (2018) · PubMed Central · Cited by 40 · see citing works

Recent imaging advances in neurology

Rocchi, L., Niccolini, F., & Politis, M. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7711-x · Cited by 39 · see citing works

Blood-brain barrier delivery for lysosomal storage disorders with IgG-lysosomal enzyme fusion proteins

Pardridge, W. M. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114234 · Cited by 37 · see citing works

Serotonin Selective Reuptake Inhibitor Treatment Improves Cognition and Grey Matter Atrophy but not Amyloid Burden During Two-Year Follow-Up in Mild Cognitive Impairment and Alzheimer’s Disease Patients with Depressive Symptoms

Brendel, M., Initiative, A. D. N., Sauerbeck, J., Greven, S., Kotz, S., Scheiwein, F., Blautzik, J., Delker, A., Pogarell, O. M., Ishii, K., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170387 · Cited by 36 · see citing works

Yeast buddies helping to unravel the complexity of neurodegenerative disorders

Fruhmann, G., Seynnaeve, D., Zheng, J., Ven, K., Molenberghs, S., Wilms, T., Liu, B., Winderickx, J., & Franssens, V. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.05.002 · Cited by 35 · see citing works

Injection of Aβ1-40 into hippocampus induced cognitive lesion associated with neuronal apoptosis and multiple gene expressions in the tree shrew

Lin, N., Xiong, L., Zhang, R., Zheng, H. Y., Wang, L., Qian, Z., Zhang, P., Chen, Z., Gao, F., & Wang, T. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1227-4 · Cited by 35 · see citing works

Synthesis of a PET tau tracer [11C]PBB3 for imaging of Alzheimer’s disease

Wang, M., Gao, M., Xu, Z., & Zheng, Q. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.08.053 · Cited by 34 · see citing works

Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease

Xu, C., Liu, G., Ji, H., Chen, W., Dai, D., Chen, Z., Zhou, D., Xu, L., Hu, H., Cui, W., et al. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9424 · Cited by 34 · see citing works

Remarkable Brain Penetration of Cyclopentadienyl M(CO)3+ (M = 99mTc, Re) Derivatives of Benzothiazole and Benzimidazole Paves the Way for Their Application as Diagnostic, with Single-Photon-Emission Computed Tomography (SPECT), and Therapeutic Agents for Alzheimer’s Disease

Sagnou, M., Mavroidi, B., Shegani, A., Paravatou‐Petsotas, M., Raptopoulou, C. P., Psycharis, V., Pirmettis, I. C., Papadopoulos, M. S., & Pelecanou, M. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01949 · Cited by 32 · see citing works

Fully automated synthesis of [18F]T807, a PET tau tracer for Alzheimer’s disease

Gao, M., Wang, M., & Zheng, Q. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.05.035 · Cited by 31 · see citing works

Amyloid-β as a biomarker for Alzheimer’s disease: quantification methods in body fluids

Galozzi, S., Marcus, K., & Barkovits, K. (2015) · Expert Review of Proteomics · doi:10.1586/14789450.2015.1065183 · Cited by 30 · see citing works

Brain and Brown Adipose Tissue Metabolism in Transgenic Tg2576 Mice Models of Alzheimer Disease Assessed Using 18 F-FDG PET Imaging

Coleman, R. A., Liang, C., Patel, R., Ali, S., & Mukherjee, J. (2017) · Molecular Imaging · doi:10.1177/1536012117704557 · Cited by 29 · see citing works

Targeting the TLR4/NF-κB pathway in β-amyloid-stimulated microglial cells: A possible mechanism that oxysophoridine exerts anti-oxidative and anti-inflammatory effects in an in vitro model of Alzheimer’s disease

Chen, R., Wang, Z., Zhi, Z., Tian, J., Zhao, Y., & Sun, J. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.07.019 · Cited by 29 · see citing works

Advances in fluorescent probes for detection and imaging of amyloid-β peptides in Alzheimer's disease

Zhang, Y., Ding, C., Li, C., & Wang, X. (2021) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.08.008 · Cited by 27 · see citing works

Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope

Lichtenegger, A., Muck, M., Eugui, P., Harper, D. J., Augustin, M., Leskovar, K., Hitzenberger, C. K. F., Wöehrer, A., & Baumann, B. (2018) · Neurophotonics · doi:10.1117/1.nph.5.3.035002 · Cited by 27 · see citing works

PET Neurochemical Imaging Modes

Placzek, M. S., Zhao, W., Wey, H., Morin, T., & Hooker, J. M. (2015) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2015.09.001 · Cited by 26 · see citing works

Erratum to: Injection of Aβ1-40 into hippocampus induced cognitive lesion associated with neuronal apoptosis and multiple gene expressions in the tree shrew

Lin, N., Xiong, L., Zhang, R., Zheng, H. Y., Wang, L., Qian, Z., Zhang, P., Chen, Z.-W., Gao, F., & Wang, T. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1240-7 · Cited by 26 · see citing works

Trends in the public health significance, definitions of disease, and implications for prevention of Alzheimer’s disease

Derby, C. A. (2020) · Current Epidemiology Reports · doi:10.1007/s40471-020-00231-8 · Cited by 26 · see citing works

Translational biomarkers: from discovery and development to clinical practice

Subramanyam, M., & Goyal, J. (2016) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2016.10.001 · Cited by 24 · see citing works

Treatment of Mild Cognitive Impairment

Kelley, B. J. (2015) · Current Treatment Options in Neurology · doi:10.1007/s11940-015-0372-3 · Cited by 23 · see citing works

Progression of Alzheimer's disease and effect of scFv‐h3D6 immunotherapy in the 3xTg‐AD mouse model: <i>An in vivo longitudinal study using Magnetic Resonance Imaging and Spectroscopy</i>

Güell‐Bosch, J., Lope‐Piedrafita, S., Esquerda‐Canals, G., Montoliu‐Gaya, L., & Villegas, S. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4263 · Cited by 21 · see citing works

Advances in PET Imaging of Degenerative, Cerebrovascular, and Traumatic Causes of Dementia

Eisenmenger, L. B., Huo, E. J., Hoffman, J. M., Minoshima, S., Matesan, M. C., Lewis, D. H., Lopresti, B. J., Mathis, C. A., Okonkwo, D. O., & Mountz, J. M. (2015) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2015.09.003 · Cited by 21 · see citing works

Saturation Transfer MRI for Detection of Metabolic and Microstructural Impairments Underlying Neurodegeneration in Alzheimer’s Disease

Orzyłowska, A., & Oakden, W. (2021) · Brain Sciences · doi:10.3390/brainsci12010053 · Cited by 20 · see citing works

Therapeutic advances in multiple system atrophy and progressive supranuclear palsy

Poewe, W. H., Mahlknecht, P., & Krismer, F. (2015) · Movement Disorders · doi:10.1002/mds.26334 · Cited by 19 · see citing works

Transformer-based approaches for neuroimaging: an in-depth review of their role in classification and regression tasks

Zhu, X., Sun, S., Lin, L., Wu, Y., & Ma, X. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0088 · Cited by 17 · see citing works

Supervised multiblock sparse multivariable analysis with application to multimodal brain imaging genetics

Kawaguchi, A., & Yamashita, F. (2017) · Biostatistics · doi:10.1093/biostatistics/kxx011 · Cited by 17 · see citing works

Coordination chemistry of ligands: Insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer’s disease

Selvan, S. T., Ravichandar, R., Ghosh, K. K., Mohan, A., Mahalakshmi, P., Gulyás, B. Z., & Padmanabhan, P. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213659 · Cited by 16 · see citing works

Synthesis, biological evaluation and preclinical study of a novel 99mTc-peptide: A targeting probe of amyloid-β plaques as a possible diagnostic agent for Alzheimer’s disease

Jokar, S., Behnammanesh, H., Erfani, M., Sharifzadeh, M. S., Gholami, M., Sabzevari, O., Amini, M., Geramifar, P., Hajiramezanali, M., & Beiki, D. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103857 · Cited by 16 · see citing works

Changes in LASSI-L performance over time among older adults with amnestic MCI and amyloid positivity: A preliminary study

Kitaigorodsky, M., Curiel, R. E., Crocco, E., Gorman, K., González-Jiménez, C. J., Greig‐Custo, M. T., Barker, W., Duara, R., & Loewenstein, D. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.08.033 · Cited by 15 · see citing works

The p38 mitogen-activated protein kinase signaling pathway is involved in regulating low-density lipoprotein receptor-related protein 1-mediated β-amyloid protein internalization in mouse brain

Ma, K., Lv, J., Hu, X. D., Shi, L., Chang, K.-W., Chen, X., Qian, Y., Yang, W., & Qu, Q. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.04.019 · Cited by 14 · see citing works

Advanced imaging of tau pathology in Alzheimer Disease: New perspectives from super resolution microscopy and label‐free nanoscopy

Schierle, G. S. K., Michel, C. H., & Gasparini, L. (2016) · Microscopy Research and Technique · doi:10.1002/jemt.22698 · Cited by 14 · see citing works

Synthesis of carbon-11-labeled isonicotinamides as new potential PET agents for imaging of GSK-3 enzyme in Alzheimer’s disease

Gao, M., Wang, M., & Zheng, Q. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.01.041 · Cited by 14 · see citing works

Neurodegenerative changes in the brains of the 5xFAD Alzheimer's disease model mice investigated by high‐field and high‐resolution magnetic resonance imaging and multi‐nuclei magnetic resonance spectroscopy

Yoo, C.-H., Kim, J., Baek, H.-M., Chang, K.-A., & Choe, B.-Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065073 · Cited by 13 · see citing works

Donepezil-loaded PLGA-b-PEG Nanoparticles Enhance the Learning and Memory Function of Beta-Amyloid Rat Model of Alzheimer’s Disease

Çınar, E., Mutluay, S. U., Baysal, İ., Gültekinoğlu, M., Ulubayram, K., Ciftci, S. Y., Tel, B. C., & Uçar, G. (2022) · Nöro Psikiyatri Arşivi · doi:10.29399/npa.28275 · Cited by 13 · see citing works

Impact of Donepezil on Brain Glucose Metabolism Assessed Using [18F]2-Fluoro-2-deoxy-D-Glucose Positron Emission Tomography Imaging in a Mouse Model of Alzheimer’s Disease Induced by Intracerebroventricular Injection of Amyloid-Beta Peptide

Hugon, G., Goutal, S., Sarazin, M., Bottlaender, M., Caillé, F., Droguerre, M., Charvériat, M., Winkeler, A., & Tournier, N. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.835577 · Cited by 13 · see citing works

Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease

Yanagisawa, D., Ibrahim, N. F., Taguchi, H., Morikawa, S., Tomiyama, T., & Tooyama, I. (2021) · Molecules · doi:10.3390/molecules26051362 · Cited by 13 · see citing works

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques

Hellberg, S., Silvola, J. M. U., Liljenbäck, H., Kiugel, M., Eskola, O., Hakovirta, H. H., Hörkkö, S., Morisson, V., Hirani, E., Saukko, P. J., et al. (2019) · Molecules · doi:10.3390/molecules24061072 · Cited by 12 · see citing works

A Metal-Free Method for Producing MRI Contrast at Amyloid-β

Hilt, S., Tang, T., Walton, J. H., Budamagunta, M. S., Maezawa, I., Kálai, T., Hideg, K., Singh, V., Wulff, H., Gong, Q., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160279 · Cited by 12 · see citing works

Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging

Maharjan, S., Tsai, A. P., Lin, P. B., Ingraham, C., Jewett, M. R., Landreth, G. E., Oblak, A. L., & Wang, N. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.964654 · Cited by 11 · see citing works

Two-Photon Fluorescent Probes for Amyloid-β Plaques Imaging In Vivo

Chen, Y. (2023) · Molecules · doi:10.3390/molecules28176184 · Cited by 11 · see citing works

Magnesium Lithospermate B Protects Neurons Against Amyloid β (1–42)-Induced Neurotoxicity Through the NF-κB Pathway

Jiang, F., Mao, Y., Liu, H., Xu, P., Zhang, L., Xiaobo, Q., & Sun, X. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1691-1 · Cited by 11 · see citing works

Critical role of mitosis in spontaneous late-onset Alzheimer’s disease; from a Shugoshin 1 cohesinopathy mouse model

Rao, C. V., Farooqui, M., Asch, A. S., & Yamada, H. Y. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1515554 · Cited by 11 · see citing works

Immunomagnetic Reduction Detects Plasma Aβ1–42 Levels as a Potential Dominant Indicator Predicting Cognitive Decline

Yang, S., Liu, H.-C., & Chen, W.-P. (2020) · Neurology and Therapy · doi:10.1007/s40120-020-00215-2 · Cited by 9 · see citing works

Microstructural mapping of dentate gyrus pathology in Alzheimer’s disease: A 16.4 Tesla MRI study

Shih, N., Kurniawan, N. D., Cabeen, R. P., Korobkova, L., Wong, E., Chui, H. C., Clark, K. A., Miller, C. A., Hawes, D., Jones, K. T., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103318 · Cited by 8 · see citing works

Regional times to equilibria and their impact on semi-quantification of [ 18 F]AV-1451 uptake

Heurling, K., Smith, R. A., Strandberg, O. T., Schain, M., Ohlsson, T. G., Hansson, O., & Schöll, M. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18791430 · Cited by 6 · see citing works

Early Detection of Amyloid β Pathology in Alzheimer’s Disease by Molecular MRI

Dong, C. M., Guo, A. S., To, A., Chan, K. W. Y., Chow, A. S. F., Bian, L., Leong, A. T. L., & Wu, E. X. (2020) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc44109.2020.9176013 · Cited by 5 · see citing works

Recent Trends in Drug Discovery against Alzheimer's Disease: Use of Natural Products and Nutraceuticals from Botanicals

Maity, S., Nandy, S., & Dey, A. M. A. (2018) · doi:10.1002/9781119436713.ch10 · Cited by 5 · see citing works

Central Nervous System

Mettler, F. A., & Guiberteau, M. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-48319-3.00003-1 · Cited by 4 · see citing works

Interactions of Cellular Energetic Gene Clusters in the Alzheimer’s Mouse Brain

Raju, R. P., Cai, L., Tyagi, A., & Pugazhenthi, S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03551-0 · Cited by 3 · see citing works

Recent Developments in Treating Alzheimer’s Disease

Žerovnik, E., & Kopitar‐Jerala, N. (2016) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000220 · Cited by 3 · see citing works

Exposure to footshock stress downregulates antioxidant genes and increases neuronal apoptosis in an Aβ(1–42) rat model of Alzheimer's disease

Faborode, O. S., Dallé, E., & Mabandla, M. V. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105170 · Cited by 3 · see citing works

Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer’s disease

Yang, M., Yan, C., Ospondpant, D., Wang, L., Lin, S., Tang, W. L., Dong, T. T.-X., Tong, P., Xu, Q., & Tsim, K. W. K. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1426569 · Cited by 2 · see citing works

The Future in Psychology

Bohall, G., & Bautista, M.-J. (2017) · Springer eBooks · doi:10.1007/978-3-319-63013-7_13 · Cited by 2 · see citing works

Brain Morphometry: Alzheimer’s Disease

Marco, M. D., & Venneri, A. (2018) · Neuromethods · doi:10.1007/978-1-4939-7647-8_14 · Cited by 2 · see citing works

Impact of Chronic Conditions and Dementia in Rural West Texas: A Healthy Aging Study

Morton, H., Basu, T., Bose, C., & Reddy, P. H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220084 · Cited by 2 · see citing works

The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions

Yang, M., Cheng, E. H., Ospondpant, D., Tung, K.-K., Wang, L., Lin, S., Lai, Q. W. S., Wu, Q., Xia, Y., Leung, K. W., et al. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105607 · Cited by 2 · see citing works

Neuroimaging in the Perioperative Neurocognitive Disorders

Ibinson, J. W. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316402504.014 · Cited by 1 · see citing works

Comparative pharmacokinetics and biodistribution of HAEE and HASS peptides

Ivanova, A., Lazareva, P. A., Kuzmichev, I., Vadekhina, V. V., Kosykh, A. V., Gurskaya, N. G., & Abakumov, M. A. (2025) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2025.036 · Cited by 1 · see citing works

Psychiatric Disorders in Dementia

Vermeiren, Y., Dam, D. V., & Deyn, P. P. D. (2014) · Springer eBooks · doi:10.1007/978-3-642-40384-2_11 · Cited by 1 · see citing works

Perturbed functional networks in Alzheimer’s Disease reveal opposing roles for TGIF and EGR3Preprint

Canchi, S., Raao, B., Masliah, D., Rosenthal, S. B., Šášik, R., Fisch, K. M., Jager, P. L. D., Bennett, D. A., & Rissman, R. A. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/286674 · Cited by 1 · see citing works

Effects of C/EBP β on APP Gene Expression

Wang, H., Chai, J., Li, Y., Lu, X., Zhang, Q., Ma, L., Sun, T., & Cui, J. (2015) · doi:10.11844/cjcb.2015.04.0404

3-Phenylpyrazino[1,2-a]indol-1(2H)-ones as dual cholinesterase and amyloid aggregation inhibitors

Gujral, S. S. (2017) · UWSpace (University of Waterloo)

Multimodal magnetic resonance imaging predicts regional amyloid- β burden in the brainPreprint

Rangarajan, A., Wu, M., Joseph, N. M., Karim, H. T., Laymon, C. M., Tudorascu, D., Cohen, A. D., Klunk, W. E., & Aizenstein, H. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.17.910984

Psychiatric Disorders in Dementia

Vermeiren, Y., Dam, D. V., de Vries, M., & Deyn, P. P. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_9

Predictive analytics in Alzheimer’s disease: pioneering memory projection

Kumar, L. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29888-2.00008-8

Multivariate Analyses with Two-Step Dimension Reduction for an Association Study Between 11C-Pittsburgh Compound B and Magnetic Resonance Imaging in Alzheimer’s Disease

Kawaguchi, A., & Yamashita, F. (2025) · Bioengineering · doi:10.3390/bioengineering12010048

The Effects of Naturally Occurring Phenols on Amyloid Fibrils from Insulin in the Liquid Phase Using Atomic Force Microscopy

Dasani, D. B., Nghiem, T. P., Facteau, K. A., Pollock, C. A., Strain, M., Zuchowski, G. E., & Moriarty, D. F. (2025) · Natural Product Communications · doi:10.1177/1934578x241306603

A novel PSEN2 mutation in amnestic early-onset Alzheimer's disease (EOAD): A familial case series

Leochico, C. F. D., Rogaeva, E. A., Zotovic, L., Oliveira, A. L. P., Le, T., Singnurkar, A., Masellis, M., & Mitchell, S. B. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251348676

Complexes métalliques pour utilisation en imagerie médicale : application à la maladie d’Alzheimer

Porqueras, D. S. D. (2016) · doi:10.70675/b908263ez07c9z441ez94d8zc53fbd818c56

New treatments on the horizon for Alzheimer’s and other neurodegenerative diseases

Bailey, H., Layfield, R., & Žerovnik, E. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34176-2.00003-1

Deep Learning-based Synthesis of Amyloid PET Images from Structural MRI in Alzheimer’s Disease

Zhang, Z., Wu, J., Wang, P., Chai, K., Jiang, S., Onyike, C. U., Smith, G. S., Zhou, J., & Initiative, A. D. N. (2026) · Molecular Imaging and Biology · doi:10.1007/s11307-026-02145-1

The influence of mutant genes APP and PSEN1 on hippocampal asymmetry in 5xFAD mice, transgenic model of Alzheimer disease

Brusentsev, E. Y., Рожкова, И. Н., Kozeneva, V. S., Chekashov, I. D., Rakhmanova, T. A., Shevelev, O. B., & Amstislavsky, S. Y. (2026) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-26-92

Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression

Teipel, S. J., Buchert, R., Thome, J., Hampel, H. J., & Pahnke, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.004 · Cited by 29 · see citing works

Current neuroimaging techniques in Alzheimer's disease and applications in animal models.

Zhang, L., Chang, R. C., Chu, L., & Mak, H. K. (2012) · Europe PMC (PubMed Central) · Cited by 31 · see citing works

Amyloid imaging: Past, present and future perspectives

Villemagne, V. L. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.005 · Cited by 64 · see citing works

Imaging and In Vivo Quantitation of β-Amyloid: An Exemplary Biomarker for Alzheimer’s Disease?

Nichols, L. M., Pike, V. W., Cai, L., & Innis, R. B. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.004 · Cited by 26 · see citing works

Recent Advances in Imaging of Preclinical, Sporadic, and Autosomal Dominant Alzheimer's Disease

Buckley, R. F. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01026-5 · Cited by 18 · see citing works