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Cited by 349

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Spin‐echo and gradient‐echo epi of human brain activation using bold contrast: A comparative study at 1.5 T

Bandettini, Peter A., Wong, Eric C., Jesmanowicz, A., Hinks, R. Scott, Hyde, James S.·1994·NMR in Biomedicine

Abstract

In this study, Blood Oxygenation Level Dependent (BOLD) contrast in the detection of human brain activation was compared between spin‐echo and gradient‐echo echo‐planar sequences at 1.5 T. Time course series of spin‐echo and gradient‐echo images containing the primary motor cortex were collected during rest (no finger movement) and activation (finger movement). Each time course series was collected using a different TE. Resting and active state signal intensities at each TE were measured in identical regions in the motor cortex. From these data, resting and active state R2 (1/T2) and R (1/T) values were obtained. Across four subjects, brain activation produced an average R2 change of −0.16±0.02/s (±SE), and an average R change of −0.55±0.08/s. The average Δ R/Δ R2 ratio was 3.52±0.56. The average gradient‐echo/spin‐echo ratio of activation‐induced signal changes at the TE for maximal BOLD contrast for each sequence (TE≈T and T2) was calculated to be 1.87±0.40.

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Metadata

Authors
Bandettini, P. A., Wong, E. C., Jesmanowicz, A., Hinks, R. S., & Hyde, J. S.
Venue
NMR in Biomedicine
Publisher
Wiley
Published
1994-03
Volume
7
Issue
1-2
Pages
12-20
ISSN
  • 0952-3480 (ISSN-L)
  • 1099-1492
OpenAlex
W2079842952
Cited by
349
References
4
FWCI
11.88
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Spin‐echo and gradient‐echo epi of human brain activation using bold contrast: A comparative study at 1.5 T. https://app.cochat.ai/papers/10.1002/nbm.1940070104
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Bandettini, P. A., Wong, E. C., Jesmanowicz, A., Hinks, R. S., & Hyde, J. S. (1994). Spin‐echo and gradient‐echo epi of human brain activation using bold contrast: A comparative study at 1.5 T. NMR in Biomedicine. https://doi.org/10.1002/nbm.1940070104

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