Time course EPI of human brain function during task activation
Abstract
Using gradient‐echo echo‐planar MRI, a local signal increase of 4.3 ± 0.3% is observed in the human brain during task activation, suggesting a local decrease in blood deoxyhemoglobin concentration and an increase in blood oxygenation. Images highlighting areas of signal enhancement temporally correlated to the task are created. © 1992 Academic Press, Inc.
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The most widely used fMRI signal is blood oxygenation level dependent and is observable with rapid pulse sequences sensitized to T2*-weighted contrast.
“The most widely used fMRI signal is blood oxygenation level dependent (BOLD) (119) and observable with rapid pulse sequences sensitized to the T2*-weighted contrast (120–122).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [120]
Cites
Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields
Ogawa, S., Lee, T., Nayak, A. S., & Glynn, P. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140108 · Cited by 2,269 · see citing works
Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056 · see citing works
Functional mapping of the human visual cortex by magnetic resonance imaging
Belliveau, J. W., Kennedy, D. N., McKinstry, R. C., Buchbinder, B. R., Weisskoff, R. M., Cohen, M. S., Vevea, J. M., Brady, T. J., & Rosen, B. R. (1991) · Science · doi:10.1126/science.1948051 · Cited by 1,883 · see citing works
Textbook of Medical Physiology
Iatridis, P. G. (1991) · JAMA · doi:10.1001/jama.1991.03470200123049 · Cited by 1,287 · see citing works
Thulborn, K. R., Waterton, J. C., Matthews, P. M., & Radda, G. K. (1982) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(82)90333-6 · Cited by 1,134 · see citing works
Villringer, A., Rosen, B. R., Belliveau, J. W., Ackerman, J. L., Lauffer, R. B., Buxton, R. B., Chao, Y. S., Wedeenand, V. J., & Brady, T. J. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910060205 · Cited by 706 · see citing works
Ogawa, S., & Lee, T. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910160103 · Cited by 565 · see citing works
Brain and Perception: Holonomy and Structure in Figural Processing
(1991) · Perceptual and Motor Skills · doi:10.1177/003151259107303s01 · Cited by 429 · see citing works
Mapping human visual cortex with positron emission tomography
Fox, P. T., Mintun, M. A., Raichle, M. E., Miezin, F. M., Allman, J. M., & Van Essen, D. C. (1986) · Nature · doi:10.1038/323806a0 · Cited by 422 · see citing works
Echo‐planar time course MRI of cat brain oxygenation changes
Turner, R., Bihan, D. L., MOONEN, C. T. W., Despres, D., & Frank, J. A. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910220117 · Cited by 421 · see citing works
Fisel, C. R., Ackerman, J. L., Buxton, R. B., Garrido, L., Belliveau, J. W., Rosen, B. R., & Brady, T. J. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910170206 · Cited by 353 · see citing works
Estimating oxygen saturation of blood in vivo with MR imaging at 1.5 T
Wright, G. A., Hu, B. S., & Macovski, A. (1991) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880010303 · Cited by 327 · see citing works
Pawlik, G., Rackl, A., & Bing, R. J. (1981) · Brain Research · doi:10.1016/0006-8993(81)90619-3 · Cited by 313 · see citing works
NMR relaxation times of blood: dependence on field strength, oxidation state, and cell integrity.
Gomori, J. M., Grossman, R. I., Yu-Ip, C., & Asakura, T. (1987) · PubMed · Cited by 213 · see citing works
Gomori, J. M., Grossman, R. I., Yu-Ip, C., & Asakura, T. (1987) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198707000-00025 · Cited by 195 · see citing works
Application of spin-echo nuclear magnetic resonance to whole-cell systems. Membrane transport
Brindle, K. M., Brown, F. F., Campbell, I. D., Grathwohl, C., & Kuchel, P. W. (1979) · Biochemical Journal · doi:10.1042/bj1800037 · Cited by 170 · see citing works
Magnetic resonance imaging of stationary blood: A review
Brooks, R. A., & Chiro, G. D. (1987) · Medical Physics · doi:10.1118/1.595994 · Cited by 137 · see citing works
Majumdar, S. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910220111 · Cited by 64 · see citing works
Hardy, P., & Henkelman, R. M. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910170207 · Cited by 60 · see citing works
T2 effect of hemoglobin concentration: assessment with in vitro MR spectroscopy.
Hayman, L. A., Ford, J. J., Taber, K. H., et al. (1988) · Radiology · doi:10.1148/radiology.168.2.3393669 · Cited by 47 · see citing works
Potchen, E. J., & Potchen, M. J. (1991) · Investigative Radiology · doi:10.1097/00004424-199103000-00013 · Cited by 6 · see citing works
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Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,542 · see citing works
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Raichle, M. E. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014030 · Cited by 3,904 · see citing works
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Logothetis, N. K. (2008) · Nature · doi:10.1038/nature06976 · Cited by 3,612 · see citing works
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Kriegeskorte, N. (2008) · Frontiers in Systems Neuroscience · doi:10.3389/neuro.06.004.2008 · Cited by 3,355 · see citing works
Ferrari, M., & Quaresima, V. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.049 · Cited by 2,274 · see citing works
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Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213 · see citing works
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Ungerleider, S. K. A. L. G. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.315 · Cited by 2,159 · see citing works
Functional MRI evidence for adult motor cortex plasticity during motor skill learning
Kami, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R., & Ungerleider, L. G. (1995) · Nature · doi:10.1038/377155a0 · Cited by 1,883 · see citing works
Ogawa, S., Menon, R. S., Tank, D. W., Kim, S. G., Merkle, H., Ellermann, J. M., & Ugurbil, K. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81441-3 · Cited by 1,772 · see citing works
Dynamics of blood flow and oxygenation changes during brain activation: the Balloon model
Buxton, R. B., Wong, E. C., & Frank, L. R. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390602 · Cited by 1,665 · see citing works
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Logothetis, N. K., & Wandell, B. A. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.082602.092845 · Cited by 1,568 · see citing works
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Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270 · see citing works
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Cramer, S. C., Nelles, G., Benson, R. R., Kaplan, J. D., Parker, R. A., Kwong, K. K., Kennedy, D. N., Finklestein, S. P., & Rosen, B. R. (1997) · Stroke · doi:10.1161/01.str.28.12.2518 · Cited by 1,019 · see citing works
Shmuel, A., Augath, M., Oeltermann, A., & Logothetis, N. K. (2006) · Nature Neuroscience · doi:10.1038/nn1675 · Cited by 898 · see citing works
Callicott, J. H. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.1.20 · Cited by 771 · see citing works
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(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.341 · Cited by 737 · see citing works
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Breiter, H. C. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830070041008 · Cited by 626 · see citing works
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Koshino, H., Carpenter, P. A., Minshew, N. J., Cherkassky, V. L., Keller, T. A., & Just, M. A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.09.028 · Cited by 614 · see citing works
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Cohen, J. D., Forman, S. D., Braver, T. S., Casey, B. J., Servan‐Schreiber, D., & Noll, D. C. (1994) · Human Brain Mapping · doi:10.1002/hbm.460010407 · Cited by 576 · see citing works
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Kim, S.-G., & Ogawa, S. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.23 · Cited by 547 · see citing works
Uludağ, K., Müller-Bierl, B., & Uğurbil, K. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.051 · Cited by 450 · see citing works
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Cho, Z. H., Chung, S. C., Jones, J. P., Park, J. B., Park, H. J., Lee, H. J., Wong, E. K., & Min, B. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2670 · Cited by 425 · see citing works
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Newman, S. D., Carpenter, P. A., Varma, S., & Just, M. A. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00091-5 · Cited by 400 · see citing works
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Fallgatter, A. J., & Strik, W. K. (1998) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050045 · Cited by 130 · see citing works
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Self-citationYang, Y., Gu, H., Zhan, W., Xu, S., Silbersweig, D. A., & Stern, E. (2002) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10196 · Cited by 77 · see citing works
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Self-citationSystems Neuroengineering: Understanding and Interacting with the Brain
Edelman, B. J., Johnson, N., Sohrabpour, A., Tong, S., Thakor, N., & He, B. (2015) · Engineering · doi:10.15302/j-eng-2015078 · Cited by 45 · see citing works
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- Authors
- Bandettini, P. A., Wong, E. C., Hinks, R. S., Tikofsky, R. S., & Hyde, J. S.
- Affiliations
- Medical College of Wisconsin (US)
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1992-06
- Volume
- 25
- Issue
- 2
- Pages
- 390-397
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2170117095
- Cited by
- 1,935
- References
- 21
- Citations by year
- 2026: 28 · 2025: 46 · 2024: 40 · 2023: 35 · 2022: 47 · 2021: 40 · 2020: 27 · 2019: 37 · 2018: 43 · 2017: 44 · 2016: 49 · 2015: 54 · 2014: 52 · 2013: 59 · 2012: 77
- FWCI
- 75.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca041464-14)
- National Cancer Institute (CA41464)
- National Center for Research Resources (P41RR001008, RR 01008)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- task activation, human brain function, blood oxygenation, signal amplification, temporal correlation
- MeSH terms
- Brain, Hemoglobins, Humans, Magnetic Resonance Imaging, Oxygen, Partial Pressure, Task Performance and Analysis
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