The effects of dietary weight loss on indices of norepinephrine turnover: Modulatory influence of hyperinsulinemia
Open accessAbstract
Objectives: This study was conducted to examine 1) the effects of dietary weight loss on indices of norepinephrine (NE) turnover and 2) whether baseline hyperinsulinemia modulates sympathetic neural adaptations. Methods: Obese individuals aged 56 ± 1 year, BMI 32.5 ± 0.4 kg/m 2, with metabolic syndrome, underwent a 12‐week hypocaloric diet (HCD, n = 39) or no treatment (n = 26). Neurochemical measurements comprised arterial dihydroxyphenylalanine (DOPA), 3,4‐dihydroxyphenylglycol (DHPG), and NE concentrations, the steady‐state ratio of [3 H]‐DHPG to [3 H]‐NE, as an index of neuronal uptake, and calculated whole‐body plasma NE clearance and spillover rates. Results: Body weight decreased by −7.4 ± 0.5% in HCD group (P < 0.001) and was accompanied by reductions in DOPA, NE, and DHPG averaging −14 ± 5% (P = 0.001), −23 ± 4% (P <0.001), and −5 ± 4% (P = 0.03), respectively. NE spillover rate decreased by −88 ± 39 ng/min (P = 0.01), whereas neuronal uptake and NE plasma clearance were unchanged. Despite similar weight loss, hyperinsulinemic subjects exhibited greater reductions in NE and NE spillover rate, compared to normoinsulinemic subjects (group by time interaction P < 0.05). Conclusions: Weight loss is associated with down‐regulation of sympathetic nervous activity but no overall alteration in disposition indices. Hyperinsulinemic subjects derive a greater sympathoinhibitory benefit during weight loss.
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A diet producing negative energy balance, with accompanying weight loss, reduces sympathetic activity and lowers blood pressure.
“A diet producing negative energy balance, with accompanying weight loss, reduces sympathetic activity and lowers blood pressure.111,112”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [112]
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- Authors
- Straznicky, N. E., Lambert, E. A., Grima, M. T., Eikelis, N., Richards, K., Nestel, P. J., Dawood, T., Masuo, K., Sari, C. I., Dixon, J. B., Esler, M. D., Paul, E., Schlaich, M. P., & Lambert, G. W.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Laboratories of Human Neurotransmitters, Baker IDI Heart & Diabetes Institute Melbourne Victoria Australia
- Monash University (AU)
- Corresponding author
- Straznicky, Nora E.
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2013-12-06
- Volume
- 22
- Issue
- 3
- Pages
- 652-662
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W1683511819
- Cited by
- 21
- References
- 40
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 3 · 2014: 3
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- Eli Lilly and Company
- Pfizer
- Diabetes Australia
- State Government of Victoria
- Servier
- Allergan
- National Health and Medical Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- dietary weight loss, norepinephrine turnover, hyperinsulinemia, sympathetic nervous system, hypocaloric diet, metabolic syndrome, adult obesity, norepinephrine spillover, norepinephrine clearance, DOPA, DHPG, sympathoinhibition
- MeSH terms
- Diet, Reducing, Dihydroxyphenylalanine, Energy Metabolism, Female, Humans, Hyperinsulinism, Male, Methoxyhydroxyphenylglycol, Middle Aged, Norepinephrine, Obesity, Sympathetic Nervous System, Weight Loss, Down-Regulation, Body Mass Index, Metabolic Syndrome, White People
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