Metabolic syndrome: a sympathetic disease?

Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity

Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works

The metabolic syndrome—a new worldwide definition

Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493 · see citing works

Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart study

Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699 · see citing works

Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol

Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407 · see citing works

Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study

Krum, H., Schlaich, M., Whitbourn, R., Sobotka, P. A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60566-3 · Cited by 2,108 · see citing works

Body Mass Index and Risk for End-Stage Renal Disease

Hsu, C.-Y., McCulloch, C. E., Iribarren, C., Darbinian, J., & Go, A. S. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-1-200601030-00006 · Cited by 1,390 · see citing works

The Metabolic Syndrome and Chronic Kidney Disease in U.S. Adults

Chen, J., Muntner, P., Hamm, L. L., Jones, D. W., Batuman, V., Fonseca, V. A., Whelton, P. K., & He, J. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-3-200402030-00007 · Cited by 1,354 · see citing works

Inflammation, Immunity, and Hypertension

Harrison, D. G., Guzik, T. J., Lob, H. E., Madhur, M. S., Marvar, P. J., Thabet, S., Vinh, A., & Weyand, C. M. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.163576 · Cited by 877 · see citing works

Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome

Coughlin, S. R. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.02.021 · Cited by 840 · see citing works

Alterations of Left Ventricular Myocardial Characteristics Associated With Obesity

Wong, C. Y., O’Moore-Sullivan, T., Leano, R., Byrne, N., Beller, E., & Marwick, T. H. (2004) · Circulation · doi:10.1161/01.cir.0000147184.13872.0f · Cited by 713 · see citing works

Obesity and risk for chronic renal failure.

Ejerblad, E., Fored, C. M., Lindblad, P., Fryzek, J., McLaughlin, J. K., & Nyren, O. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005060638 · Cited by 651 · see citing works

Continuous Positive Airway Pressure Treatment Rapidly Improves Insulin Sensitivity in Patients with Obstructive Sleep Apnea Syndrome

Harsch, I. A., Schahin, S. P., Radespiel-Tröger, M., Weintz, O., Jahreiß, H., Fuchs, F. S., Wiest, G. H., Hahn, E. G., Lohmann, T., Konturek, P. C., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200302-206oc · Cited by 583 · see citing works

Effect of Renal Sympathetic Denervation on Glucose Metabolism in Patients With Resistant Hypertension

Mahfoud, F., Schlaich, M. P., Kindermann, I., Ukena, C., Cremers, B., Brandt, M. C., Hoppe, U. C., Vonend, O., Rump, L. C., Sobotka, P. A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.991869 · Cited by 572 · see citing works

Sympathetic Neural Activation in Visceral Obesity

Alvarez, G. E., Beske, S. D., Ballard, T. P., & Davy, K. P. (2002) · Circulation · doi:10.1161/01.cir.0000041244.79165.25 · Cited by 557 · see citing works

Functional and Structural Changes in the Kidney in the Early Stages of Obesity

HENEGAR, J. R., BIGLER, S. A., HENEGAR, L. K., TYAGI, S. C., & HALL, J. E. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1261211 · Cited by 549 · see citing works

The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals

Reaven, G. M. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.03.002 · Cited by 506 · see citing works

Fasting, Feeding and Regulation of the Sympathetic Nervous System

Landsberg, L., & Young, J. B. (1978) · New England Journal of Medicine · doi:10.1056/nejm197806082982306 · Cited by 498 · see citing works

Nocturnal Continuous Positive Airway Pressure Decreases Daytime Sympathetic Traffic in Obstructive Sleep Apnea

Narkiewicz, K., Kato, M., Phillips, B. G., Pesek, C. A., Davison, D. E., & Somers, V. K. (1999) · Circulation · doi:10.1161/01.cir.100.23.2332 · Cited by 485 · see citing works

Effects of Renal Sympathetic Denervation on Blood Pressure, Sleep Apnea Course, and Glycemic Control in Patients With Resistant Hypertension and Sleep Apnea

Witkowski, A., Prejbisz, A., Florczak, E., Kądziela, J., Śliwiński, P., Bieleń, P., Michałowska, I., Kabat, M., Warchoł, E., Januszewicz, M., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.173799 · Cited by 460 · see citing works

Relation Between Cardiac Sympathetic Activity and Hypertensive Left Ventricular Hypertrophy

Schlaich, M. P., Kaye, D. M., Lambert, E., Sommerville, M., Socratous, F., & Esler, M. D. (2003) · Circulation · doi:10.1161/01.cir.0000081775.72651.b6 · Cited by 459 · see citing works

Mechanisms of Sympathetic Activation in Obesity-Related Hypertension

Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., & Lambert, E. (2006) · Hypertension · doi:10.1161/01.hyp.0000242642.42177.49 · Cited by 443 · see citing works

Measures of Obesity Are Associated With Vascular Stiffness in Young and Older Adults

Wildman, R. P., Mackey, R. H., Bostom, A., Thompson, T., & Sutton-Tyrrell, K. (2003) · Hypertension · doi:10.1161/01.hyp.0000090360.78539.cd · Cited by 441 · see citing works

The sympathetic nervous system and the metabolic syndrome

Mancia, G., Bousquet, P., Elghozi, J. L., Esler, M., Grassi, G., Julius, S., Reid, J., & Van Zwieten, P. A. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328048d004 · Cited by 385 · see citing works

Prospective effect of job strain on general and central obesity in the Whitehall II Study.

Brunner, E., Chandola, T., & Marmot, M. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwk058 · Cited by 383 · see citing works

Substantial Reduction in Single Sympathetic Nerve Firing After Renal Denervation in Patients With Resistant Hypertension

Hering, D., Lambert, E. A., Marusic, P., Walton, A. S., Krum, H., Lambert, G. W., Esler, M. D., & Schlaich, M. P. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00194 · Cited by 356 · see citing works

Influence of obesity on the appearance of proteinuria and renal insufficiency after unilateral nephrectomy

Praga, M., Hernández, E., Herrero, J. C., Morales, E., Revilla, Y., Díaz‐González, R., & Rodicio, J. L. (2000) · Kidney International · doi:10.1111/j.1523-1755.2000.00384.x · Cited by 351 · see citing works

Hypothesis: β-Adrenergic Receptor Blockers and Weight Gain

Sharma, A. M., Pischon, T., Hardt, S., Kunz, I., & Luft, F. C. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.250 · Cited by 339 · see citing works

Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues

Dusserre, E., Moulin, P., & Vidal, H. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(99)00091-5 · Cited by 323 · see citing works

Reflex sympathetic activation induces acute insulin resistance in the human forearm.

Jamerson, K. A., Julius, S., Gudbrandsson, T., Andersson, O., & Brant, D. O. (1993) · Hypertension · doi:10.1161/01.hyp.21.5.618 · Cited by 311 · see citing works

Association between microalbuminuria and the metabolic syndrome: NHANES III

Palaniappan, L. P. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(03)01009-4 · Cited by 309 · see citing works

Excessive body weight as a new independent risk factor for clinical and pathological progression in primary IgA nephritis

Bonnet, F., Deprele, C., Sassolas, A., Moulin, P., Alamartine, É., Berthézène, F., & Berthoux, F. C. (2001) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(01)80120-7 · Cited by 307 · see citing works

Obesity, Insulin Resistance, and the Metabolic Syndrome

Lteif, A. A., Han, K., & Mather, K. J. (2005) · Circulation · doi:10.1161/circulationaha.104.520130 · Cited by 305 · see citing works

Metabolic syndrome and chronic kidney disease

Singh, A. K., & Kari, J. A. (2013) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32835dda78 · Cited by 299 · see citing works

Interactions Between Leptin and the Human Sympathetic Nervous System

Eikelis, N., Schlaich, M., Aggarwal, A., Kaye, D., & Esler, M. (2003) · Hypertension · doi:10.1161/01.hyp.0000066289.17754.49 · Cited by 271 · see citing works

Psychosocial Stress at Work Doubles the Risk of Type 2 Diabetes in Middle-Aged Women

Heraclides, A., Chandola, T., Witte, D. R., & Brunner, E. J. (2009) · Diabetes Care · doi:10.2337/dc09-0132 · Cited by 235 · see citing works

The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study

Charles, M.-A. A., Eschwège, É., Thibult, N., Claude, J., Warnet, J., Rosselin, G., Girard, J. R., & Balkau, B. (1997) · Diabetologia · doi:10.1007/s001250050793 · Cited by 231 · see citing works

Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications

Kalil, G. Z., & Haynes, W. G. (2011) · Hypertension Research · doi:10.1038/hr.2011.173 · Cited by 228 · see citing works

Effects of Dietary Weight Loss on Sympathetic Activity and Cardiac Risk Factors Associated with the Metabolic Syndrome

Straznicky, N. E., Lambert, E. A., Lambert, G. W., Masuo, K., Esler, M. D., & Nestel, P. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0961 · Cited by 227 · see citing works

Obstructive Sleep Apnea–Dependent and –Independent Adrenergic Activation in Obesity

Grassi, G. M., Facchini, A., Trevano, F. Q., Dell’Oro, R., Arenare, F., Tana, F., Bolla, G. B., Monzani, A., Robuschi, M., & Mancia, G. (2005) · Hypertension · doi:10.1161/01.hyp.0000174243.39897.6c · Cited by 214 · see citing works

Sympathetic Nervous System Activity Is Associated With Obesity-Induced Subclinical Organ Damage in Young Adults

Lambert, E., Sari, C. I., Dawood, T., Nguyen, J., McGrane, M., Eikelis, N., Chopra, R., Wong, C., Chatzivlastou, K., Head, G., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.155663 · Cited by 209 · see citing works

Increased Subclinical Atherosclerosis in Young Adults With Metabolic Syndrome

Tzou, W. S., Douglas, P. S., Srinivasan, S. R., Bond, M. G., Tang, R., Chen, W., Berenson, G. S., & Stein, J. H. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.04.046 · Cited by 206 · see citing works

Differing Pattern of Sympathoexcitation in Normal-Weight and Obesity-Related Hypertension

Lambert, E., Straznicky, N., Schlaich, M., Esler, M., Dawood, T., Hotchkin, E., & Lambert, G. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.094649 · Cited by 195 · see citing works

Sympathetic Nerve Hyperactivity Precedes Hyperinsulinemia and Blood Pressure Elevation in a Young, Nonobese Japanese Population

Masuo, K. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00303-2 · Cited by 193 · see citing works

Reversibility of Cardiac Abnormalities in Morbidly Obese Adolescents

Ippisch, H. M., Inge, T. H., Daniels, S. R., Wang, B., Khoury, P. R., Witt, S. A., Glascock, B. J., Garcia, V. F., & Kimball, T. R. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.12.029 · Cited by 191 · see citing works

CHRONIC MENTAL STRESS IS A CAUSE OF ESSENTIAL HYPERTENSION: PRESENCE OF BIOLOGICAL MARKERS OF STRESS

Esler, M., Eikelis, N., Schlaich, M., Lambert, G., Alvarenga, M., Dawood, T., Kaye, D., Barton, D., Pier, C., Guo, L., et al. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04904.x · Cited by 170 · see citing works

Autonomic-Immune-Vascular Interaction

Zubcevic, J. A., Waki, H., Raizada, M. K., & Paton, J. F. R. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.169748 · Cited by 167 · see citing works

Weight Gain–Induced Blood Pressure Elevation

Masuo, K., Mikami, H., Ogihara, T., & Tuck, M. L. (2000) · Hypertension · doi:10.1161/01.hyp.35.5.1135 · Cited by 155 · see citing works

The Interconnection between Sympathetics, Microcirculation, and Insulin Resistance in Hypertension

Julius, S., Gudbrandsson, T., Jamerson, K., & Andersson, O. (1992) · Blood Pressure · doi:10.3109/08037059209065119 · Cited by 154 · see citing works

Autonomic Contribution to Blood Pressure and Metabolism in Obesity

Shibao, C., Gamboa, A., Diedrich, A., Ertl, A. C., Chen, K. Y., Byrne, D. W., Farley, G., Paranjape, S. Y., Davis, S. N., & Biaggioni, I. (2007) · Hypertension · doi:10.1161/01.hyp.0000251679.87348.05 · Cited by 147 · see citing works

Renal denervation: a potential new treatment modality for polycystic ovary syndrome?

Schlaich, M. P., Straznicky, N. E., Grima, M. T., Sari, C. I., Dawood, T., Mahfoud, F., Lambert, É., Chopra, R., Socratous, F., Hennebry, S. C., et al. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328344db3a · Cited by 141 · see citing works

Stress‐related Development of Obesity and Cortisol in Women

Vicennati, V., Pasqui, F., Cavazza, C., Pagotto, U., & Pasquali, R. (2009) · Obesity · doi:10.1038/oby.2009.76 · Cited by 138 · see citing works

Reduced Myocardial Nerve Growth Factor Expression in Human and Experimental Heart Failure

Kaye, D. M., Vaddadi, G., Gruskin, S., Du, X., & Esler, M. (2000) · Circulation Research · doi:10.1161/01.res.86.7.e80 · Cited by 136 · see citing works

Glucose metabolism in cirrhosis: A review with some perspectives for the future

Petrides, A. S., & DeFronzo, R. A. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050805 · Cited by 130 · see citing works

Subcutaneous obesity is not associated with sympathetic neural activation

Alvarez, G. E., Ballard, T. P., Beske, S. D., & Davy, K. P. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01046.2003 · Cited by 121 · see citing works

Sympathetic Neural Adaptation to Hypocaloric Diet With or Without Exercise Training in Obese Metabolic Syndrome Subjects

Straznicky, N. E., Lambert, É., Nestel, P. J., McGrane, M. T., Dawood, T., Schlaich, M. P., Masuo, K., Eikelis, N., de Courten, B. V., Mariani, J. A., et al. (2009) · Diabetes · doi:10.2337/db09-0934 · Cited by 118 · see citing works

Lowering of Microalbuminuria in Diabetic Patients by a Sympathicoplegic Agent: Novel Approach to Prevent Progression of Diabetic Nephropathy?

STROJEK, K., GRZESZCZAK, W., GÓRSKA, J., LESCHINGER, M. I., & RITZ, E. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v123602 · Cited by 112 · see citing works

Overweight and Sympathetic Overactivity in Black Americans

Abate, N. I., Mansour, Y., Tuncel, M., Arbique, D., Chavoshan, B., Kizilbash, A. M., Howell‐Stampley, T., Vongpatanasin, W., & Victor, R. G. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.379 · Cited by 110 · see citing works

Body Weight Changes with β-Blocker Use: Results from GEMINI

Messerli, F. H., Bell, D. S. H., Fonseca, V. A., Katholi, R. E., McGill, J. B., Phillips, R. A., Raskin, P., Wright, J. T., Bangalore, S., Holdbrook, F. K., et al. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.10.017 · Cited by 109 · see citing works

Impact of the obesity epidemic on hypertension and renal disease

Hall, J. E., Jones, D. W., Kuo, J. J., da Silva, A. A., Tallam, L. S., & Liu, J. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0084-z · Cited by 106 · see citing works

The Effects of Weight Loss Versus Weight Loss Maintenance on Sympathetic Nervous System Activity and Metabolic Syndrome Components

Straznicky, N. E., Grima, M. T., Eikelis, N., Nestel, P. J., Dawood, T., Schlaich, M. P., Chopra, R., Masuo, K., Esler, M., Sari, C. I., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2204 · Cited by 102 · see citing works

Glucose intolerance and insulin resistance in cirrhosis are normalized after liver transplantation

Merli, M., Leonetti, F., Riggio, O., et al. (1999) · Hepatology · doi:10.1002/hep.510300306 · Cited by 98 · see citing works

Relation of Childhood Risk Factors to Left Ventricular Hypertrophy (Eccentric or Concentric) in Relatively Young Adulthood (from the Bogalusa Heart Study)

Toprak, A. C., Wang, H., Chen, W., Paul, T. K., Srinivasan, S. R., & Berenson, G. S. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.01.045 · Cited by 98 · see citing works

Moxonidine improves insulin sensitivity in insulin-resistant hypertensives.

Haenni, A., & Lithell, H. (1999) · PubMed · Cited by 96 · see citing works

What is the contribution of obesity to the metabolic syndrome?

Grundy, S. M. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.03.001 · Cited by 96 · see citing works

A comparative histochemical and immunohistochemical study of aminergic, cholinergic and peptidergic innervation in rat, hamster, guinea pig, dog and human livers

Akiyoshi, H., Gonda, T., & Terada, T. (1998) · Liver · doi:10.1111/j.1600-0676.1998.tb00817.x · Cited by 94 · see citing works

Modest weight gain is associated with sympathetic neural activation in nonobese humans

Gentile, C. L., Orr, J. S., Davy, B. M., & Davy, K. P. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00876.2006 · Cited by 92 · see citing works

Moxonidine treatment of hypertensive patients with advanced renal failure

Vonend, O., Marsalek, P., Russ, H., Wulkow, R., Oberhauser, V., & Rump, L. C. (2003) · Journal of Hypertension · doi:10.1097/00004872-200309000-00021 · Cited by 91 · see citing works

Differential Effects of β-Blockers on Albuminuria in Patients With Type 2 Diabetes

Bakris, G. L., Fonseca, V. A., Katholi, R. E., et al. (2005) · Hypertension · doi:10.1161/01.hyp.0000190585.54734.48 · Cited by 82 · see citing works

Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance

Doronzo, G., Russo, I., Mattiello, L., Anfossi, G., Bosìa, A., & Trovati, M. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01412.x · Cited by 80 · see citing works

Dyslipidemia Is Associated With Sympathetic Nervous Activation and Impaired Endothelial Function in Young Females

Lambert, É., Straznicky, N. E., Sari, C. I., Eikelis, N., Hering, D., Head, G. A., Dixon, J. B., Esler, M., Schlaich, M. P., & Lambert, G. W. (2012) · American Journal of Hypertension · doi:10.1093/ajh/hps016 · Cited by 79 · see citing works

Effect of chronic angiotensin converting enzyme inhibition on sympathetic nerve traffic and baroreflex control of the circulation in essential hypertension

Grassi, G., Turri, C., DellʼOro, R., Stella, M. L., Bolla, G. B., & Mancia, G. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816120-00012 · Cited by 77 · see citing works

Statins and the autonomic nervous system

Millar, P. J., & Floras, J. S. (2013) · Clinical Science · doi:10.1042/cs20130332 · Cited by 75 · see citing works

Abnormal Neurovascular Control during Sympathoexcitation in Obesity

Kuniyoshi, F. H. S., Trombetta, I. C., Batalha, L. T., Rondon, M. U. P. B., Laterza, M. C., Gowdak, M. M. G., Barretto, A. C. P., Halpern, A., Villares, S. M. F., Lima, E. G., et al. (2003) · Obesity Research · doi:10.1038/oby.2003.190 · Cited by 74 · see citing works

Moxonidine improves glycaemic control in mildly hypertensive, overweight patients: a comparison with metformin

Chazova, I. E., Almazov, V. A., & Shlyakhto, E. V. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00606.x · Cited by 74 · see citing works

Effect of angiotensin II receptor blockade on autonomic nervous system function in patients with essential hypertension

Krum, H., Lambert, É., Windebank, E., Campbell, D. J., & Esler, M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00885.2005 · Cited by 73 · see citing works

Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal

DiCostanzo, C. A., Dardevet, D. P., Neal, D. W., Lautz, M., Allen, E. J., Snead, W. L., & Cherrington, A. D. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00184.2005 · Cited by 73 · see citing works

Neuroendocrine abnormalities in human obesity

Björntorp, P. A. (1995) · Metabolism · doi:10.1016/0026-0495(95)90208-2 · Cited by 69 · see citing works

Obstructive Sleep Apnea is Associated with Increased Chemoreflex Sensitivity in Patients with Metabolic Syndrome

Trombetta, I. C., Maki‐Nunes, C., Toschi‐Dias, E., Alves, M. N. N., Rondon, M. U. P. B., Cepeda, F. X., Drager, L. F., Braga, A., Lorenzi‐Filho, G., & Negrão, C. E. (2012) · SLEEP · doi:10.5665/sleep.2298 · Cited by 68 · see citing works

Effect of glycaemic control on myocardial sympathetic innervation assessed by [ 123 I]metaiodobenzylguanidine scintigraphy: a 4-year prospective study in IDDM patients

Ziegler, D., Weise, F., Langen, K., et al. (1998) · Diabetologia · doi:10.1007/s001250050928 · Cited by 64 · see citing works

Innervation of the liver: morphology and function

TINIAKOS, D. G., Lee, J. A., & Burt, A. D. (1996) · Liver International · doi:10.1111/j.1600-0676.1996.tb00721.x · Cited by 64 · see citing works

Intralipid Enhances α 1 -Adrenergic Receptor–Mediated Pressor Sensitivity

Haastrup, A. T., Stepniakowski, K. T., Goodfriend, T. L., & Egan, B. M. (1998) · Hypertension · doi:10.1161/01.hyp.32.4.693 · Cited by 63 · see citing works

Experimental Hyperleptinemia Acutely Increases Vasoconstrictory Sympathetic Nerve Activity in Healthy Humans

Machleidt, F., Simon, P., Krapalis, A. F., Hallschmid, M., Lehnert, H., & Sayk, F. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3009 · Cited by 61 · see citing works

Comparison of carvedilol and metoprolol on serum lipid concentration in diabetic hypertensive patients

Bell, D. S. H., Bakris, G. L., & McGill, J. B. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00927.x · Cited by 60 · see citing works

Intracoronary Angiotensin II Potentiates Coronary Sympathetic Vasoconstriction in Humans

Saino, A. T., Pomidossi, G. A., Perondi, R., Valentini, R., Rimini, A., Francesco, L. D., & Mancia, G. (1997) · Circulation · doi:10.1161/01.cir.96.1.148 · Cited by 58 · see citing works

Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals

Sverrisdóttir, Y. B., Jansson, L. M., Hägg, U., & Gan, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009257 · Cited by 58 · see citing works

Non-esterified fatty acids increase arterial pressure via central sympathetic activation in humans

Florian, J. P., & Pawelczyk, J. A. (2009) · Clinical Science · doi:10.1042/cs20090063 · Cited by 57 · see citing works

Insulin Resistance Syndrome and Left Ventricular Mass in Healthy Young People

Davis, C. L., Kapuku, G. K., Treiber, F. A., Kumar, M., & Snieder, H. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200208000-00005 · Cited by 54 · see citing works

Muscle sympathetic nerve activity and hemodynamic alterations in middle-aged obese women

Ribeiro, M. M., Trombetta, I. C., Batalha, L. T., Rondon, M. U. P. B., Forjaz, C. L. M., Barretto, A. C. P., Villares, S. M., & Negrão, C. E. (2001) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2001000400006 · Cited by 54 · see citing works

Sympathoadrenergic and metabolic factors are involved in ambulatory blood pressure rise in childhood obesity

Gilardini, L., Parati, G., Sartório, A., Mazzilli, G., Pontiggia, B., & Invitti, C. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002288 · Cited by 50 · see citing works

The Functional Importance of Sympathetic Nerves to the Liver and Endocrine Pancreas

Järhult, J., FALCK, B., Ingemansson, S., & Nobin, A. (1979) · Annals of Surgery · doi:10.1097/00000658-197901000-00018 · Cited by 49 · see citing works

Hostility and Urine Norepinephrine Interact to Predict Insulin Resistance: The VA Normative Aging Study

Zhang, J., NIAURA, R. S., Dyer, J. R., Shen, B., Todaro, J. F., McCaffery, J. M., Spiro, A., & Ward, K. D. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000228343.89466.11 · Cited by 44 · see citing works

Altered neurovascular control of the resting circulation in human metabolic syndrome

Limberg, J. K., Morgan, B. J., Sebranek, J. J., Proctor, L. T., Walker, B. J., Eldridge, M. W., & Schrage, W. G. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.239780 · Cited by 43 · see citing works

Simvastatin reduces sympathetic activity in men with hypertension and hypercholesterolemia

Lewandowski, J., Siński, M., Bidiuk, J., Abramczyk, P., Dobosiewicz, A., Ciarka, A., & Gaciong, Z. A. (2010) · Hypertension Research · doi:10.1038/hr.2010.137 · Cited by 43 · see citing works

European Society of Hypertension Working Group on Obesity Antihypertensive effects of weight loss: myth or reality?

Straznicky, N. E., Grassi, G. M., Esler, M., Lambert, G. W., Dixon, J. B., Lambert, É., Jordan, J., & Schlaich, M. P. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833778e1 · Cited by 42 · see citing works

Angiotensin II receptor blockers improve endothelial dysfunction associated with sympathetic hyperactivity in metabolic syndrome

Kishi, T., Hirooka, Y., Konno, S., & Sunagawa, K. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328355860e · Cited by 41 · see citing works

The Effect of Moxonidine on Endothelial Dysfunction in Metabolic Syndrome

Topal, E., Çıkım, A. S., Çıkım, K., Temel, İ., & Оздемир, Р. (2006) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200606050-00007 · Cited by 40 · see citing works

Alpha 1-blockade for the treatment of hypertension: a megastudy of terazosin in 2214 clinical practice settings.

Itskovitz, H. D. (1994) · PubMed · Cited by 35 · see citing works

Differential effect of β‐blocker therapy on insulin resistance as a function of insulin sensitizer use: results from GEMINI

Fonseca, V. A., Bakris, G. L., Bell, D. S. H., McGill, J. B., Raskin, P., Messerli, F. H., Phillips, R. A., Katholi, R. E., Wright, J. T., Waterhouse, B. R., et al. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02151.x · Cited by 29 · see citing works

Simvastatin reduces sympathetic outflow and augments endothelium-independent dilation in non-hyperlipidaemic primary hypertension

McGowan, C. L. M., Murai, H., Millar, P. J., Notarius, C. F., Morris, B. L., & Floras, J. S. (2012) · Heart · doi:10.1136/heartjnl-2012-302980 · Cited by 29 · see citing works

The Relation of Glucose Metabolism to Left Ventricular Mass and Function and Sympathetic Nervous System Activity in Obese Subjects With Metabolic Syndrome

Straznicky, N. E., Grima, M. T., Sari, C. I., Karapanagiotidis, S., Wong, C. Y., Eikelis, N., Dell, K. L., Lee, G., Nestel, P. J., Dixon, J. B., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3277 · Cited by 27 · see citing works

Modulation of Sympathetic Coronary Vasoconstriction by Cardiac Renin-Angiotensin System in Human Coronary Heart Disease

Saino, A. T., Pomidossi, G. A., Perondi, R., Morganti, A., Turolo, L., & Mancia, G. (2000) · Circulation · doi:10.1161/01.cir.101.19.2277 · Cited by 26 · see citing works

Hypertension and its treatment influence changes in fasting nonesterified fatty acid concentrations: A link between the sympathetic nervous system and the metabolic syndrome?

Maison, P., Byrne, C. D., Hales, C. N., & Wareham, N. J. (2000) · Metabolism · doi:10.1016/s0026-0495(00)90788-1 · Cited by 24 · see citing works

Is there a relationship between left ventricular mass and plasma glucose and lipids independent of body mass index? Results of the Gubbio study

Ferrara, A. M., Vaccaro, O., Cardoni, O., Panarelli, W., Laurenzi, M. W., & Zanchetti, A. (2003) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/s0939-4753(03)80171-0 · Cited by 24 · see citing works

The effects of dietary weight loss on indices of norepinephrine turnover: Modulatory influence of hyperinsulinemia

Straznicky, N. E., Lambert, E. A., Grima, M. T., Eikelis, N., Richards, K., Nestel, P. J., Dawood, T., Masuo, K., Sari, C. I., Dixon, J. B., et al. (2014) · Obesity · doi:10.1002/oby.20614 · Cited by 21 · see citing works

Forearm haemodynamics in obese normotensive and hypertensive subjects

Raison, J., Safar, M. E., Cambien, F., & London, G. M. (1988) · Journal of Hypertension · doi:10.1097/00004872-198804000-00006 · Cited by 21 · see citing works

Adiposity-independent sympathetic activity in black men

Abbas, A., Szczepaniak, L. S., Tuncel, M., McGavock, J., Huet, B. A., Fadel, P. J., Wang, Z., Arbique, D., Victor, R. G., & Vongpatanasin, W. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00058.2010 · Cited by 16 · see citing works

Moxonidine: a new antiadrenergic antihypertensive agent.

Prichard, B. N. C., Graham, B. R., & Owens, C. W. I. (1999) · PubMed · Cited by 16 · see citing works

Renal norepinephrine spillover during infusion of nonesterified fatty acids

Grekin, R. J., Ngarmukos, C., Williams, D. M., & Supiano, M. A. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.10.013 · Cited by 14 · see citing works

Adrenergic blockade improved insulin resistance in patients with morning hypertension: the Japan Morning Surge-1 study

Shibasaki, S., Eguchi, K., Matsui, Y., Ishikawa, J., Hoshide, S., Ishikawa, S., Kabutoya, T., Pickering, T. G., Shimada, K., & Kario, K. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832a6d6a · Cited by 14 · see citing works

Understanding loneliness in the twenty-first century: an update on correlates, risk factors, and potential solutions

Lim, M. H., Eres, R., & Vasan, S. (2020) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-020-01889-7 · Cited by 438 · see citing works

Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome

Thorp, A. A., & Schlaich, M. P. (2015) · Journal of Diabetes Research · doi:10.1155/2015/341583 · Cited by 425 · see citing works

SGLT2 Inhibitor–Induced Sympathoinhibition

Herat, L. Y., Magno, A. L., Rudnicka, C., Hricova, J., Carnagarin, R., Ward, N. C., Arcambal, A., Kiuchi, M. G., Head, G. A., Schlaich, M. P., et al. (2020) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2019.11.007 · Cited by 233 · see citing works

Role of the sympathetic nervous system in regulation of the sodium glucose cotransporter 2

Matthews, V. B., Elliot, R. H., Rudnicka, C., Hricova, J., Herat, L., & Schlaich, M. P. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001434 · Cited by 222 · see citing works

A kidney perspective on the mechanism of action of sodium glucose co-transporter 2 inhibitors

Sen, T., & Heerspink, H. J. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.02.016 · Cited by 161 · see citing works

Effect of SGLT2 Inhibitors on the Sympathetic Nervous System and Blood Pressure

Scheen, A. J. (2019) · Current Cardiology Reports · doi:10.1007/s11886-019-1165-1 · Cited by 122 · see citing works

The Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Sympathetic Nervous Activity

Wan, N., Rahman, A., Hitomi, H., & Nishiyama, A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00421 · Cited by 115 · see citing works

Relationship between Changes in Components Associated with Metabolic Syndrome and Disappearance, or Remission, of Metabolic Syndrome during 1 Year

Chang, H.-C., Horng, J. T., Chau, T.-T., et al. (2012) · Journal of International Medical Research · doi:10.1177/030006051204000629 · Cited by 5 · see citing works

A study on metabolic syndrome in patients with Psoriasis

Babu, A. R., Srivastava, A., Reddy, R. R., et al. (2021) · IP Indian Journal of Clinical and Experimental Dermatology · Cited by 1 · see citing works

Editorial Note on Metabolic Syndrome.

Delacour, F. (2021) · Journal of genetics and molecular biology

Study of non-alcoholic fatty liver disease in metabolic syndrome

Shaikh Mohammed Aslam, S., & Bhanuprakash, P. (2018) · International Journal of Advances in Medicine · doi:10.18203/2349-3933.ijam20184758 · Cited by 3 · see citing works

Particular characteristics in patients with reaven’s syndrome

Helou, D., Ceasovschih, A., Șorodoc, V., et al. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.06.491