Greater hunger and less restraint predict weight loss success with phentermine treatment
Open accessAbstract
Objective: Phentermine is thought to cause weight loss through a reduction in hunger. It was hypothesized that higher hunger ratings would predict greater weight loss with phentermine. Methods: This is an observational pilot study in which all subjects were treated with phentermine for 8 weeks and appetite and eating behaviors were measured at baseline and week 8. Outcomes were compared in subjects with ≥5% vs. <5% weight loss, and linear regression was used to identify predictors of percent weight loss. Results: Twenty‐seven subjects (37 ± 4.5 years, 93.8 ± 12.1 kg, BMI 33.8 ± 3.1 kg m−2) completed the study, with mean weight loss of −5.4 ± 3.3 kg (−5.7% ± 3.2%). Subjects with ≥5% weight loss had higher baseline pre‐breakfast hunger (P = 0.017), desire to eat (P =0.003), and prospective food consumption (0.006) and lower baseline cognitive restraint (P = 0.01). In addition, higher baseline home prospective food consumption (P = 0.002) and lower baseline cognitive restraint (P < 0.001) were found to be predictors of weight loss. Conclusions: These results suggest that individuals reporting greater hunger and less restraint are more likely to achieve significant weight loss with phentermine. This information can be used clinically to determine who might benefit most from phentermine treatment.
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Some evidence suggests that phentermine might be more effective in people who eat excessively owing to hunger (as opposed to emotional stress, boredom, etc).
“Some evidence suggests that phentermine might be more effective in people who eat excessively owing to hunger (as opposed to emotional stress, boredom, etc).148”
From Effectiveness and safety of drugs for obesity (2024) · cites this paper as [148]
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- Authors
- Thomas, E. A., Mcnair, B., Bechtell, J. L., Ferland, A., Cornier, M., & Eckel, R. H.
- Affiliations
- University of Colorado Anschutz (US)
- Colorado School of Public Health (US)
- Division of Endocrinology Metabolism and Diabetes Department of Medicine University of Colorado School of Medicine, Anschutz Medical Campus Aurora Colorado USA
- Corresponding author
- Thomas, Elizabeth A.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2015-11-20
- Volume
- 24
- Issue
- 1
- Pages
- 37-43
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC4688167
- OpenAlex
- W2180924923
- Semantic Scholar
- 2f74959373d5826e36191dd599a9a9bdf20b81c1
- Cited by
- 30
- References
- 37
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 4
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH/NCRR Colorado CTSI (UL1 RR025780)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- phentermine, weight loss, appetite, hunger, cognitive restraint, dietary habits, desire to eat, prospective food consumption, predictors of weight loss, obesity treatment
- MeSH terms
- Adult, Appetite, Feeding Behavior, Female, Humans, Hunger, Male, Middle Aged, Obesity, Phentermine, Pilot Projects, Weight Loss, Treatment Outcome, Breakfast
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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