Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction
Open accessAbstract
Objective: To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). Methods: A primary cohort ( N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort ( N = 22). Results: After surgery‐induced weight loss, Minnesota Living with Heart Failure questionnaire scores, cardiac mass, and liver fat decreased ( P < 0.02, P < 0.001, and P = 0.007, respectively); echo‐derived e′ increased ( P = 0.03), but cardiac fat was unchanged. Although weight loss was associated with decreases in many plasma ceramide and sphingolipid species, plasma lipid and cardiac function changes did not correlate. Conclusions: Surgery‐induced weight loss in women with HFpEF and obesity was associated with improved symptoms, reverse cardiac remodeling, and improved relaxation. Although weight loss was associated with plasma sphingolipidome changes, cardiac function improvement was not associated with lipidomic or myocardial triglyceride changes. The results of this study suggest that gastric bypass ameliorates obesity‐related HFpEF and that cardiac fat deposition and lipidomic changes may not be critical to its pathogenesis.
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Weight loss improves symptoms of HFpEF.
“Conversely, weight loss improves symptoms of HFpEF (322).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [322]
The Conclusion reports improved heart-failure symptoms after gastric bypass–induced weight loss in women with obesity-related HFpEF. The citing sentence omits those population and intervention limits, presenting the finding as applying to weight loss and HFpEF generally. (LLM, conf=0.84)
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- Authors
- Mikhalkova, D., Holman, S. R., Jiang, H., Saghir, M., Novak, E., Coggan, A. R., O'Connor, R., Bashir, A., Jamal, A., Ory, D. S., Schaffer, J. E., Eagon, J. C., & Peterson, L. R.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Peterson, Linda R.
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2017-12-15
- Volume
- 26
- Issue
- 2
- Pages
- 284-290
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC5783730
- OpenAlex
- W2772076325
- Cited by
- 121
- References
- 38
- Citations by year
- 2026: 11 · 2025: 25 · 2024: 19 · 2023: 19 · 2022: 7 · 2021: 17 · 2020: 11 · 2019: 6 · 2018: 5
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Funders
- National Institutes of Health (P20 HL113444, P30 DK 020579, P30 DK 056341, UL1 TR000448)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- bariatric surgery, gastric bypass, heart failure with preserved ejection fraction, cardiac fat, plasma lipidome, sphingolipids, ceramide, weight loss, cardiac remodeling, myocardial relaxation, liver fat, women
- MeSH terms
- Female, Heart, Heart Failure, Humans, Male, Middle Aged, Obesity, Stroke Volume, Bariatric Surgery
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