Effects of Bariatric Surgery on Cardiac Ectopic Fat
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Objectives This study investigated the effect of bariatric surgery (BS)-induced weight loss on cardiac ectopic fat using 3T magnetic resonance imaging in morbid obesity.Background Heart disease is one of the leading causes of mortality and morbidity in obese patients. Deposition of cardiac ectopic fat has been related to increased heart risk. Whether sustained weight loss can modulate epicardial fat or myocardial fat is unknown.Methods Twenty-three morbidly obese patients underwent 1H-magnetic resonance spectroscopy to determine myocardial triglyceride content (MTGC), magnetic resonance imaging to assess epicardial fat volume (EFV), cardiac function, and computed tomography visceral abdominal fat (VAF) measurements at baseline and 6 months after BS.Results The BS reduced body mass index significantly, from 43.1±4.5 kg/m2 to 32.3±4.0 kg/m2, subcutaneous fat from 649±162 cm2 to 442±127 cm2, VAF from 190±83 cm2 to 107±44 cm2, and EFV from 137±37 ml to 98±25 ml (all p<0.0001). There was no significant change in MTGC: 1.03±0.2% versus 1.1±0.2% (p=0.85). A significant reduction in left ventricular mass (118±24 g vs. 101±18 g) and cardiac output (7.1±1.6 l/min vs. 5.4±1.0 l/min) was observed and was statistically associated with weight loss (p<0.05). The loss in EFV was limited (-27±11%) compared to VAF diminution (-40±19%). The EFV variation was not correlated with percentage of body mass index or VAF loss (p=0.007). The ratio of %EFV to %VAF loss decreased with sleep apnea syndrome (1.34±0.3 vs. 0.52±0.08, p<0.05).Conclusions Six-month BS modulates differently cardiac ectopic fat deposition, with a significant decrease in epicardial fat and no change in myocardial fat. Epicardial fat volume loss was limited in patients with sleep apnea. (Impact of Bariatric Surgery on Epicardial Adipose Tissue and on Myocardial Function; NCT01284816).
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Bariatric surgery is significantly associated with EAT shrinking in some but not all studies.
“Bariatric surgery was significantly associated with EAT shrinking in some but not all studies [141,142,143].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [142]
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- Authors
- Gaborit, B., Jacquier, A., Kober, F., Abdesselam, I., Cuisset, T., Boullu-Ciocca, S., Emungania, O., Alessi, M.-C., Clément, K., Bernard, M., & Dutour, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Hôpital Nord (FR)
- Corresponding author
- Gaborit, Bénédicte
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 60
- Issue
- 15
- Pages
- 1381-1389
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W97668167
- Cited by
- 205
- References
- 42
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 12 · 2023: 15 · 2022: 21 · 2021: 17 · 2020: 15 · 2019: 13 · 2018: 13 · 2017: 16 · 2016: 23 · 2015: 10 · 2014: 11 · 2013: 20 · 2012: 2
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Fondation de France and European Community (201100)
- Association Régionale d'Assistance Respiratoire à Domicile
- Société Francophone du Diabète
- Lilly
- Fondation de la Recherche Médicale
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- bariatric surgery, epicardial adipose tissue, myocardial fat, myocardial triglyceride content, morbid obesity, weight loss, sleep apnea, visceral fat, left ventricular mass, cardiac function, obesity cardiomyopathy, 1H magnetic resonance spectroscopy, cardiac magnetic resonance imaging, body mass index reduction
- MeSH terms
- Adult, Female, Follow-Up Studies, Heart Diseases, Humans, Male, Myocardium, Magnetic Resonance Spectroscopy, Obesity, Morbid, Pericardium, Retrospective Studies, Risk Factors, Tomography, X-Ray Computed, Triglycerides, Body Mass Index, Magnetic Resonance Imaging, Cine, Bariatric Surgery, Intra-Abdominal Fat, Lipid Metabolism
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