The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Effect of Obesity and Insulin Resistance on Myocardial Substrate Metabolism and Efficiency in Young Women
Abstract
Background— Obesity is a risk factor for impaired cardiac performance, particularly in women. Animal studies suggest that alterations in myocardial fatty acid metabolism and efficiency in obesity can cause decreased cardiac performance. In the present study, we tested the hypothesis that myocardial fatty acid metabolism and efficiency are abnormal in obese women. Methods and Results— We studied 31 young women (body mass index [BMI] 19 to 52 kg/m 2 ); 19 were obese (BMI >30 kg/m 2 ). Myocardial oxygen consumption (MV̇ o 2 ) and fatty acid uptake (MFAUp), utilization (MFAU), and oxidation (MFAO) were quantified by positron emission tomography. Cardiac work was measured by echocardiography, and efficiency was calculated as work/MV̇ o 2 . BMI correlated with MV̇ o 2 ( r =0.58, P =0.0006), MFAUp ( r =0.42, P <0.05), and efficiency ( r =−0.40, P <0.05). Insulin resistance, quantified by the glucose area under the curve (AUC) during an oral glucose tolerance test, correlated with MFAUp ( r =0.55, P <0.005), MFAU ( r =0.62, P <0.001), and MFAO ( r =0.58, P <0.005). A multivariate, stepwise regression analysis showed that BMI was the only independent predictor of MV̇ o 2 and efficiency ( P =0.0005 and P <0.05, respectively). Glucose AUC was the only independent predictor of MFAUp, MFAU, and MFAO ( P <0.05, <0.005, and <0.005, respectively). Conclusions— In young women, obesity is a significant predictor of increased MV̇ o 2 and decreased efficiency, and insulin resistance is a robust predictor of MFAUp, MFAU, and MFAO. This increase in fatty acid metabolism and decrease in efficiency is concordant with observations made in experimental models of obesity. These metabolic changes may play a role in the pathogenesis of decreased cardiac performance in obese women.
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Obese subjects, particularly those with insulin resistance, have increased myocardial fatty acid uptake and utilization.
“This observation is supported by the findings of Peterson et al. (278) who showed that obese subjects, particularly those with insulin resistance, have increased myocardial fatty acid uptake and utilization (278).”
From Cardiac remodeling in obesity (2008) · cites this paper as [278]
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Metadata
- Authors
- Peterson, L. R., Herrero, P., Schechtman, K. B., Racette, S. B., Waggoner, A. D., Kisrieva-Ware, Z., Dence, C., Klein, S., Marsala, J., Meyer, T., & Gropler, R. J.
- Affiliations
- Washington University in St. Louis (US)
- From the Department of Medicine, Divisions of Cardiology (L.R.P., A.D.W., R.J.G.) and Geriatrics and Nutritional Science (L.R.P., S.B.R., S.K., J.M., T.M.); Mallinckrodt Institute of Radiology (P.H., Z.K.-.W., C.D., R.J.G.), and the Department of Biostatistics (K.B.S.) of Washington University School of Medicine, St Louis, Mo.
- Venue
- Circulation
- Published
- 2004-05-11
- Volume
- 109
- Issue
- 18
- Pages
- 2191-2196
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2122167119
- Cited by
- 656
- References
- 39
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 24 · 2023: 31 · 2022: 30 · 2021: 31 · 2020: 27 · 2019: 29 · 2018: 25 · 2017: 32 · 2016: 39 · 2015: 33 · 2014: 33 · 2013: 40 · 2012: 36
- FWCI
- 17.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl013581-29)
- National Institute on Aging (AG15466, R01AG015466)
- National Heart, Lung, and Blood Institute (HL69100, HL13581, HL-79130, R01HL069100)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK56341, P30DK056341)
- National Center for Research Resources (RR.00036)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD145902)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, insulin resistance, myocardial fatty acid metabolism, myocardial efficiency, myocardial oxygen consumption, fatty acid uptake, fatty acid oxidation, cardiac work, young women, cardiac function, body mass index, glucose tolerance
- MeSH terms
- Adult, Blood Glucose, Cardiac Output, Echocardiography, Energy Metabolism, Fatty Acids, Female, Glucose, Glucose Tolerance Test, Heart, Hemodynamics, Humans, Insulin Resistance, Myocardium, Obesity, Oxygen Consumption, Tomography, Emission-Computed, Body Mass Index, Premenopause, Ventricular Dysfunction, Left, Area Under Curve
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