Cited by 24Functional Brain Connectivity StudiesEating Disorders and BehaviorsNeural and Behavioral Psychology Studies

Weight-Related differences in salience, default mode, and executive function network connectivity in adolescents

Open access
Borowitz, Michelle A., Yokum, Sonja, Duval, Elizabeth R., Gearhardt, Ashley N.·2020·Obesity

Abstract

OBJECTIVE: The current study examined whether adolescents with weight status ranging from lean to obesity showed weight-related differences in the default mode network (DMN), the executive function network (EFN), and the salience network (SN). METHODS: One hundred sixty-four adolescents participated in a resting-state functional connectivity scan. A general linear model was used to examine differences in scan patterns among adolescents with lean weight, overweight, and obesity. RESULTS: Adolescents with obesity compared with those with lean weight showed stronger within-SN connectivity among the medial orbitofrontal cortex, olfactory tubercle, and pallidum; however, they showed lower connectivity between the amygdala and SN regions (nucleus accumbens, thalamus, putamen). Those with obesity also showed lower connectivity between SN (amygdala, caudate) and DMN (parahippocampus, hippocampus, precuneus) regions. Adolescents with obesity compared with those with lean weight showed lower connectivity between SN (medial orbitofrontal cortex) and EFN (ventrolateral prefrontal cortex) regions. CONCLUSIONS: Obesity appears to be related to stronger connectivity within and between regions implicated in determining the salience of stimuli, which may have implications for reward processing. Lower connectivity between SN and EFN regions may suggest that executive-control efforts are going "off-line" when salience and reward-processing regions are engaged in adolescents who have obesity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/oby.22853

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Authors
Borowitz, M. A., Yokum, S., Duval, E. R., & Gearhardt, A. N.
Affiliations
  • University of Michigan (US)
  • Oregon Research Institute (US)
Corresponding author
  • Borowitz, Michelle A.
  • Gearhardt, Ashley N.
Venue
Obesity
Publisher
Wiley
Published
2020-07-06
Volume
28
Issue
8
Pages
1438-1446
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
OpenAlex
W3042022709
Cited by
24
References
46
Citations by year
2026: 4 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 1
FWCI
1.61
Type
journal article
Language
en
Open access
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK102532)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
adolescent obesity, weight status, salience network, default mode network, resting-state functional connectivity, medial orbitofrontal cortex, amygdala, medial prefrontal cortex, reward processing, executive function
MeSH terms
Adolescent, Adult, Brain, Child, Preschool, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Young Adult, Executive Function

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review