The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease
Abstract
Mucosal changes in inflammatory bowel disease (IBD) are characterized by ulcerative lesions accompanied by prominent cellular infiltrates in the bowel wall. Chemokines are chemotactic cytokines that are able to promote leukocyte migration to areas of inflammation and are also able to initiate cell activation events. They have recently been implicated in the pathophysiology of many disease states. The aim of this study was to detail the degree and distribution of specific chemokines, interleukin (IL)‐8, monocyte chemoattractant protein (MCP)‐1, ‐2, and ‐3, and macrophage inflammatory protein (MIP)‐1α and ‐1β, in IBD mucosa. Thirty‐nine patients were included, ten controls, 20 ulcerative colitis (UC), and nine Crohn's disease (CD), with a range of disease activity. Colonic mucosal biopsies were collected from UC, CD, and control patients and embedded in glycol methacrylate. Two‐micrometre‐thick sections were cut and stained using immunohistochemistry for chemokine protein expression. Sections were analysed using a light microscope. Expression of all types of chemokine protein was detected in colonic mucosa from both control and IBD patients. Patterns of staining between IBD patients and controls differed significantly, but CD and UC patients demonstrated similar patterns of staining. Individual chemokine expression was found to be significantly up‐regulated in IBD when patients were compared with the non‐diseased group in all areas of the mucosal sections. Up‐regulated chemokine expression correlated with increasing activity of the disease. It is concluded that human colonic chemokine expression is non‐selectively up‐regulated in IBD. The results supported the hypothesis that the degree of local inflammation and tissue damage in UC and CD is dependent on local expression of specific chemokines within IBD tissues. Copyright © 2002 John Wiley & Sons, Ltd.
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Cites
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,987
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,630
Jung, H. C., Eckmann, L., Yang, S. K., Panja, A., Fierer, J., Morzycka-Wroblewska, E., & Kagnoff, M. F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117676 · Cited by 1,197
Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β
Strieter, R. M., Kunkel, S. L., Showell, H. J., Remick, D. G., Phan, S. H., Ward, P. A., & Marks, R. M. (1989) · Science · doi:10.1126/science.2648570 · Cited by 775
Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry
Eckmann, L., Kagnoff, M. F., & Fierer, J. (1993) · Infection and Immunity · doi:10.1128/iai.61.11.4569-4574.1993 · Cited by 654
Larsen, C. G., Anderson, A. O., Oppenheim, J. J., & Matsushima, K. (1989) · PubMed Central · Cited by 424
Signals and Receptors Involved in Recruitment of Inflammatory Cells
Ben-Baruch, A., Michiel, D. F., & Oppenheim, J. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.11703 · Cited by 411
Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease.
Daig, R., Andus, T., Aschenbrenner, E., Falk, W., Schölmerich, J., & Gross, V (1996) · Gut · doi:10.1136/gut.38.2.216 · Cited by 291
Reinecker, H., Loh, E. Y., Ringler, D. J., Mehta, A., Rombeau, J. L., & MacDermott, R. P. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90006-3 · Cited by 290
Mazzucchelli, L., Hauser, C. J., Z’graggen, K., Wagner, H., Hess, M. W., Laissue, J. A., & Mueller, C. (1994) · PubMed Central · Cited by 286
Cited by
Sekirov, I., Tam, N. M., Jogova, M., Robertson, M. L., Li, Y., Lupp, C., & Finlay, B. B. (2008) · Infection and Immunity · doi:10.1128/iai.00319-08 · Cited by 490
De Marco, S., Sichetti, M., Muradyan, D., Piccioni, M., Traina, G., Pagiotti, R., & Pietrella, D. (2018) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2018/1756308 · Cited by 297
Rhee, S. H., Im, E., Riegler, M., Kokkotou, E., O'Brien, M., & Pothoulakis, C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502174102 · Cited by 229
Fucoidan Extracts Ameliorate Acute Colitis
Lean, Q. Y., Eri, R. D., Fitton, J. H., Patel, R. P., & Gueven, N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0128453 · Cited by 142
Rhee, S. H., Keates, A. C., Moyer, M. P., & Pothoulakis, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400967200 · Cited by 81
Gijsbers, K., Van Assche, G., Joossens, S., Struyf, S., Proost, P., Rutgeerts, P., Geboes, K., & Van Damme, J. (2004) · European Journal of Immunology · doi:10.1002/eji.200324807 · Cited by 77
Metadata
- Authors
- Banks, C., Bateman, A., Payne, R., Johnson, P., & Sheron, N.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2002-10-09
- Volume
- 199
- Issue
- 1
- Pages
- 28-35
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2062626858
- Cited by
- 344
- References
- 26
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
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