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Cited by 391

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Sequential dermal microvascular and perivascular changes in the development of scleroderma

Prescott, Richard J., Freemont, Anthony J., Jones, Carolyn J. P., Hoyland, Judith, Fielding, Patricia·1992·The Journal of Pathology
DOI 10.1002/path.1711660307
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Abstract

It has been previously proposed that there is a primary microvascular abnormality in patients with systemic sclerosis. In this study using conventional light and electron microscopy, immunohistochemistry, and labelled adenosine uptake techniques, changes in the dermal microvasculature have been related to the various clinical stages of skin disease in systemic sclerosis. The earliest pathological changes are seen in clinically normal skin. They constitute changes in endothelial cell function and their consequences. Perivascular oedema is an early feature. With progression in the clinical disease, there is, at first, an inflammatory cell infiltrate into the dermis, particularly the papillary and mid‐dermis, and platelet aggregation within vessels. Further clinical progression is associated with increasing dermal fibrosis, loss of adnexae, and vascular effacement. It is postulated that the recruitment of different types of mononuclear cells into the dermis is causally linked with the preceding endothelial cell dysfunction and the subsequent induction of fibroblast proliferation and collagen synthesis.

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Crossref · 10.1002/path.1711660307

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Metadata

Authors
Prescott, R. J., Freemont, A. J., Jones, C. J. P., Hoyland, J., & Fielding, P.
Venue
The Journal of Pathology
Publisher
Wiley
Published
1992-03
Volume
166
Issue
3
Pages
255-263
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
DOI
10.1002/path.1711660307
OpenAlex
W2131121772
Cited by
391
References
30
FWCI
3.56
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.