The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Cancer invasion and metastasis: changing views
Abstract
The formation of distant metastasis is the main cause of morbidity and mortality in patients with cancer. The aim of this article is to review recent advances in molecular and clinical aspects of metastasis. Traditionally, genes encoding extracellular matrix (ECM) processing proteases, adhesion proteins, and motility factors were thought to be amongst the main mediators of metastasis. Recently, however, genes activated during the early stages of tumourigenesis were implicated in the process. Conversely, genes thought to be primarily involved in metastasis such as urokinase plasminogen (uPA) and certain matrix metalloproteases (MMPs) are now known to also play a role in the early steps of tumour progression, perhaps by stimulating cell proliferation and/or promoting angiogenesis. Paradoxically, certain endogenous protease inhibitors such as PAI‐1 and TIMP‐1 appear to promote cancer metastasis rather than inhibiting the process. These recent advances in our understanding should lead to the development of new molecular markers for predicting the likely formation of metastasis as well as the identification of new targets for anti‐metastatic therapies. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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New functions for the matrix metalloproteinases in cancer progression
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Cited by
RAS Interaction with PI3K: More Than Just Another Effector Pathway
Castellano, E., & Downward, J. (2011) · Genes & Cancer · doi:10.1177/1947601911408079 · Cited by 762
Current and emerging concepts in tumour metastasis
Coghlin, C., & Murray, G. I. (2010) · The Journal of Pathology · doi:10.1002/path.2727 · Cited by 257
3D tumor models: History, advances and future perspectives
Benien, P., & Swami, A. (2014) · Future Oncology · doi:10.2217/fon.13.274 · Cited by 208
Kolenda, J., Jensen, S. S., Aaberg-Jessen, C., Christensen, K., Andersen, C., Brünner, N., & Kristensen, B. W. (2011) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0357-8 · Cited by 144
TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling
Lee, S. Y., Kim, J. M., Cho, S. Y., Kim, H. S., Shin, H. S., Jeon, J. Y., Kausar, R., Jeong, S. Y., Lee, Y. S., & Lee, M. A. (2014) · Biochemical Journal · doi:10.1042/bj20131119 · Cited by 60
Metadata
- Authors
- Duffy, M., McGowan, P., & Gallagher, W.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2008-01-10
- Volume
- 214
- Issue
- 3
- Pages
- 283-293
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2068721684
- Cited by
- 302
- References
- 14
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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