The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
Abstract
Small non‐coding microRNAs (miRNAs) contribute to cancer development and progression, and are differentially expressed in normal tissues and cancers. However, the specific role of miRNAs in the metastatic process is still unknown. To seek a specific miRNA expression signature characterizing the metastatic phenotype of solid tumours, we performed a miRNA microarray analysis on 43 paired primary tumours (ten colon, ten bladder, 13 breast, and ten lung cancers) and one of their related metastatic lymph nodes. We identified a metastatic cancer miRNA signature comprising 15 overexpressed and 17 underexpressed miRNAs. Our results were confirmed by qRT‐PCR analysis. Among the miRNAs identified, some have a well‐characterized association with cancer progression, eg miR‐10b, miR‐21, miR‐30a, miR‐30e, miR‐125b, miR‐141, miR‐200b, miR‐200c, and miR‐205. To further support our data, we performed an immunohistochemical analysis for three well‐defined miRNA gene targets (PDCD4, DHFR, and HOXD10 genes) on a small series of paired colon, breast, and bladder cancers, and one of their metastatic lymph nodes. We found that the immunohistochemical expression of these targets significantly follows the corresponding miRNA deregulation. Our results suggest that specific miRNAs may be directly involved in cancer metastasis and that they may represent a novel diagnostic tool in the characterization of metastatic cancer gene targets. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNA expression profiles classify human cancers
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Self-citationOncomirs—MicroRNAs with a role in cancer
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A microRNA expression signature of human solid tumors defines cancer gene targets
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Self-citationHuman microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
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Self-citationMicroRNA Gene Expression Deregulation in Human Breast Cancer
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A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
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TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
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Davalos, V, Moutinho, C., Villanueva, A., Boque, R., Silva, P., Carneiro, F., & Esteller, M. (2012) · Oncogene · doi:10.1038/onc.2011.383 · Cited by 351
Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring
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Metadata
- Authors
- Baffa, R., Fassan, M., Volinia, S., O'Hara, B., Liu, C., Palazzo, J. P., Gardiman, M., Rugge, M., Gomella, L. G., Croce, C. M., & Rosenberg, A.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2009-07-10
- Volume
- 219
- Issue
- 2
- Pages
- 214-221
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W1994061059
- Cited by
- 473
- References
- 52
- FWCI
- 16.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baffa, R., Fassan, M., Volinia, S., O'Hara, B., Liu, C., Palazzo, J. P., Gardiman, M., Rugge, M., Gomella, L. G., Croce, C. M., & Rosenberg, A. (2009). MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. The Journal of Pathology. https://doi.org/10.1002/path.2586
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