The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
Abstract
Small non‐coding microRNAs (miRNAs) contribute to cancer development and progression, and are differentially expressed in normal tissues and cancers. However, the specific role of miRNAs in the metastatic process is still unknown. To seek a specific miRNA expression signature characterizing the metastatic phenotype of solid tumours, we performed a miRNA microarray analysis on 43 paired primary tumours (ten colon, ten bladder, 13 breast, and ten lung cancers) and one of their related metastatic lymph nodes. We identified a metastatic cancer miRNA signature comprising 15 overexpressed and 17 underexpressed miRNAs. Our results were confirmed by qRT‐PCR analysis. Among the miRNAs identified, some have a well‐characterized association with cancer progression, eg miR‐10b, miR‐21, miR‐30a, miR‐30e, miR‐125b, miR‐141, miR‐200b, miR‐200c, and miR‐205. To further support our data, we performed an immunohistochemical analysis for three well‐defined miRNA gene targets (PDCD4, DHFR, and HOXD10 genes) on a small series of paired colon, breast, and bladder cancers, and one of their metastatic lymph nodes. We found that the immunohistochemical expression of these targets significantly follows the corresponding miRNA deregulation. Our results suggest that specific miRNAs may be directly involved in cancer metastasis and that they may represent a novel diagnostic tool in the characterization of metastatic cancer gene targets. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNA expression profiles classify human cancers
Lu, J., Getz, G., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,539
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1997 · Cited by 7,590
Self-citationOncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Self-citationHuman microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
Calin, G. A., Sevignani, C., Dumitru, C. D., Hyslop, T., Noch, E., Yendamuri, S., Shimizu, M., Rattan, S., Bullrich, F., Negrini, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307323101 · Cited by 4,095
Self-citationMicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Self-citationGregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew-Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,863
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605
A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
Calin, G. A., Ferracin, M., Cimmino, A., Di Leva, G., Shimizu, M., Wojcik, S. E., Iorio, M. V., Visone, R., Sever, N. I., Fabbri, M., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050995 · Cited by 2,403
Self-citationPark, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272
Asangani, I. A., Rasheed, S. A. K., Nikolova, D. A., Leupold, J. H., Colburn, N. H., Post, S., & Allgayer, H. (2008) · Oncogene · doi:10.1038/sj.onc.1210856 · Cited by 1,882
MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866
Endogenous human microRNAs that suppress breast cancer metastasis
Tavazoie, S. F., Alarcón, C., Oskarsson, T., Padua, D., Wang, Q., Bos, P. D., Gerald, W. L., & Massagué, J. (2008) · Nature · doi:10.1038/nature06487 · Cited by 1,857
Burk, U., Schubert, J., Wellner, U., Schmalhofer, O., Vincan, E., Spaderna, S., & Brabletz, T. (2008) · EMBO reports · doi:10.1038/embor.2008.74 · Cited by 1,722
Korpal, M., Lee, E. S., Hu, G., & Kang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800074200 · Cited by 1,645
miRNAs, Cancer, and Stem Cell Division
Croce, C. M., & Calin, G. A. (2005) · Cell · doi:10.1016/j.cell.2005.06.036 · Cited by 1,329
Self-citationTili, E., Michaille, J.-J., Cimino, A., Costinean, S., Dumitru, C. D., Adair, B., Fabbri, M., Alder, H., Liu, C. G., Calin, G. A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5082 · Cited by 1,304
Self-citationRegulation of progenitor cell proliferation and granulocyte function by microRNA-223
Johnnidis, J. B., Harris, M. H., Wheeler, R. T., Stehling-Sun, S., Lam, M. H., Kirak, O., Brummelkamp, T. R., Fleming, M. D., & Camargo, F. D. (2008) · Nature · doi:10.1038/nature06607 · Cited by 1,208
Yan, L.-X., Huang, X.-F., Shao, Q., Huang, M.-Y., Deng, L., Wu, Q.-L., Zeng, Y.-X., & Shao, J.-Y. (2008) · RNA · doi:10.1261/rna.1034808 · Cited by 1,148
Frankel, L. B., Christoffersen, N. R., Jacobsen, A., Lindow, M., Krogh, A., & Lund, A. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707224200 · Cited by 1,141
Bloomston, M., Frankel, W. L., Petrocca, F., Volinia, S., Alder, H., Hagan, J. P., Liu, C.-G., Bhatt, D., Taccioli, C., & Croce, C. M. (2007) · JAMA · doi:10.1001/jama.297.17.1901 · Cited by 1,141
Self-citationExtensive modulation of a set of microRNAs in primary glioblastoma
Ciafrè, S. A., Galardi, S., Mangiola, A., Ferracin, M., Liu, C.-G., Sabatino, G., Negrini, M., Maira, G., Croce, C. M., & Farace, M. G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.030 · Cited by 1,096
Self-citationA microRNA DNA methylation signature for human cancer metastasis
Lujambio, A., Calin, G. A., Villanueva, A., Ropero, S., Sánchez-Céspedes, M., Blanco, D., Montuenga, L. M., Rossi, S., Nicoloso, M. S., Faller, W. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803055105 · Cited by 1,078
Self-citationBracken, C. P., Gregory, P. A., Kolesnikoff, N., Bert, A. G., Wang, J., Shannon, M. F., & Goodall, G. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1942 · Cited by 1,060
MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
Zhu, S., Wu, H., Wu, F., Nie, D., Sheng, S., & Mo, Y.-Y. (2008) · Cell Research · doi:10.1038/cr.2008.24 · Cited by 1,051
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
Huang, Q., Gumireddy, K., Schrier, M., le Sage, C., Nagel, R., Nair, S., Egan, D. A., Li, A., Huang, G., Klein-Szanto, A. J., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1681 · Cited by 975
An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues
Liu, C.-G., Calin, G. A., Meloon, B., Gamliel, N., Sevignani, C., Ferracin, M., Dumitru, C. D., Shimizu, M., Zupo, S., Dono, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403293101 · Cited by 948
Self-citationMicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
Blenkiron, C., Goldstein, L. D., Thorne, N. P., Spiteri, I., Chin, S.-F., Dunning, M. J., Barbosa-Morais, N. L., Teschendorff, A. E., Green, A. R., Ellis, I. O., et al. (2007) · Genome Biology · doi:10.1186/gb-2007-8-10-r214 · Cited by 948
MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
Shuomin, Zhu, Hailong, H., Wu, Fangting, Daotai, Nie, Shijie, Sheng, Yin-Yuan, et al. (2008) · Cell Research · Cited by 831
Roldo, C., Missiaglia, E., Hagan, J. P., Falconi, M., Capelli, P., Bersani, S., Calin, G. A., Volinia, S., Liu, C.-G., Scarpa, A., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.5194 · Cited by 775
Self-citationMicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
Schickel, R., Boyerinas, B., Park, S.-M., & Peter, M. E. (2008) · Oncogene · doi:10.1038/onc.2008.274 · Cited by 719
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
Lu, Z., Liu, M., Stribinskis, V, Klinge, C. M., Ramos, K. S., Colburn, N. H., & Li, Y. (2008) · Oncogene · doi:10.1038/onc.2008.72 · Cited by 711
Identification of metastasis-related microRNAs in hepatocellular carcinoma
Budhu, A., Jia, H.-L., Forgues, M., Liu, C.-G., Goldstein, D., Lam, A., Zanetti, K. A., Ye, Q.-H., Qin, L.-X., Croce, C. M., et al. (2008) · Hepatology · doi:10.1002/hep.22160 · Cited by 697
Self-citationKong, W., Yang, H., He, L., Zhao, J.-J., Coppola, D., Dalton, W. S., & Cheng, J. Q. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00941-08 · Cited by 689
MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammation
Sonkoly, E., Ståhle, M., & Pivarcsi, A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.01.005 · Cited by 523 · cited 1×
“This was confirmed by the significant deregulation in our analysis of miRNAs which have not been involved in carcinogenesis, but have been typically described as deregulated in cells of the inflammatory response, eg miR-142-5p, miR-146a, miR-146b-5p, miR150, miR-151-3p, miR181, and miR-223 [28–36].”
BackgroundPerry, M. M., Moschos, S. A., Williams, A. E., Shepherd, N. J., Larner-Svensson, H. M., & Lindsay, M. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5689 · Cited by 461
Mishra, P. J., Humeniuk, R., Mishra, P. J., Longo-Sorbello, G. S. A., Banerjee, D., & Bertino, J. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706217104 · Cited by 417
Moschos, S. A., Williams, A. E., Perry, M. M., Birrell, M. A., Belvisi, M. G., & Lindsay, M. A. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-240 · Cited by 283
Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis
Chen, Y., Knösel, T., Kristiansen, G., Pietas, A., Garber, M. E., Matsuhashi, S., Ozaki, I., & Petersen, I. (2003) · The Journal of Pathology · doi:10.1002/path.1378 · Cited by 265
Breast cancer metastasis: a microRNA story
Negrini, M., & Calin, G. A. (2008) · Breast Cancer Research · doi:10.1186/bcr1867 · Cited by 205
Mudduluru, G., Medved, F., Grobholz, R., Jost, C., Gruber, A., Leupold, J. H., Post, S., Jansen, A., Colburn, N. H., & Allgayer, H. (2007) · Cancer · doi:10.1002/cncr.22983 · Cited by 196
Nass, D., Rosenwald, S., Meiri, E., Gilad, S., Tabibian‐Keissar, H., Schlosberg, A., Kuker, H., Sion‐Vardy, N., Tobar, A., Kharenko, O., et al. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00184.x · Cited by 195
Worley, L. A., Long, M. D., Onken, M. D., & Harbour, J. W. (2008) · Melanoma Research · doi:10.1097/cmr.0b013e3282feeac6 · Cited by 162
Re-evaluation of mammary stem cell biology based on in vivotransplantation
Smith, G. H., & Medina, D. (2008) · Breast Cancer Research · doi:10.1186/bcr1856 · Cited by 153
Sustained Expression of Homeobox D10 Inhibits Angiogenesis
Myers, C. A., Charboneau, A. L., Cheung, I., Hanks, D. K., & Boudreau, N. J. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64488-4 · Cited by 147
Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21Waf1/Cip1
Göke, R., Barth, P. J., Schmidt, A., Samans, B., & Lankat–Buttgereit, B. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00025.2004 · Cited by 138
MicroRNAs, the immune system and rheumatic disease
Tili, E., Michaille, J., Costinean, S., & Croce, C. M. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0885 · Cited by 127
Self-citationHomeobox D10 Induces Phenotypic Reversion of Breast Tumor Cells in a Three-Dimensional Culture Model
Carrió, M., Arderiu, G., Myers, C. A., & Boudreau, N. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1717 · Cited by 118
Aberrant expression of HOX genes in human invasive breast carcinoma
Makiyama, K., Hamada, J.-I., Takada, M., Murakawa, K., Takahashi, Y., Tada, M., Tamoto, E., Shindo, G., Matsunaga, A., Teramoto, K., et al. (2005) · Oncology Reports · doi:10.3892/or.13.4.673 · Cited by 115
Nuovo, G. J., & Schmittgen, T. D. (2008) · Diagnostic Molecular Pathology · doi:10.1097/pdm.0b013e31815aca19 · Cited by 66
Montenegro, D. A., Romero, R. J., Pineles, B. L., Tarca, A. L., Kim, Y. M., Drăghici, S., Kusanovic, J. P., Kim, J.-S., Erez, O., Mazaki‐Tovi, S., et al. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.06.027 · Cited by 56
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Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model
Ma, L., Reinhardt, F., Pan, E., Soutschek, J., Bhat, B., Marcusson, E. G., Teruya-Feldstein, J., Bell, G. W., & Weinberg, R. A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1618 · Cited by 772
Nosho, K., Baba, Y., Tanaka, N., Shima, K., Hayashi, M., Meyerhardt, J. A., Giovannucci, E., Dranoff, G., Fuchs, C. S., & Ogino, S. (2010) · The Journal of Pathology · doi:10.1002/path.2774 · Cited by 502
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
Su, X., Chakravarti, D., Cho, M. S., Liu, L., Gi, Y. J., Lin, Y.-L., Leung, M. L., El-Naggar, A., Creighton, C. J., Suraokar, M. B., et al. (2010) · Nature · doi:10.1038/nature09459 · Cited by 419
Davalos, V, Moutinho, C., Villanueva, A., Boque, R., Silva, P., Carneiro, F., & Esteller, M. (2012) · Oncogene · doi:10.1038/onc.2011.383 · Cited by 351
Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring
McGuire, A., Brown, J. A. L., & Kerin, M. J. (2015) · Cancer and Metastasis Reviews · doi:10.1007/s10555-015-9551-7 · Cited by 329
Metadata
- Authors
- Baffa, R., Fassan, M., Volinia, S., O'Hara, B., Liu, C., Palazzo, J. P., Gardiman, M., Rugge, M., Gomella, L. G., Croce, C. M., & Rosenberg, A.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2009-07-10
- Volume
- 219
- Issue
- 2
- Pages
- 214-221
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W1994061059
- Cited by
- 473
- References
- 52
- FWCI
- 16.22
- Type
- journal article
- Language
- en
- Open access
- closed
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