A transdiagnostic comparison of affective decision‐making in patients with schizophrenia, major depressive disorder, or bipolar disorder
Abstract
Deficit in decision‐making has been found in patients with schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD), respectively, while the common and distinct characteristics of this deficit among these patients are still unclear. The present study aimed to make a transdiagnostic comparison of the affective decision‐making ability in patients with SCZ, MDD, and BD. In this study, 33 patients with SCZ, 23 patients with MDD, 29 patients with BD, and 34 healthy controls (HCs) were recruited and the Iowa Gambling Task (IGT) was used to assess the affective decision‐making ability. The results showed that all three diagnostic groups tended to select the disadvantageous decks but not advantageous decks compared to HCs. For patients with SCZ, an excessive preference for the disadvantageous decks with larger‐magnitude less frequent punishments (deck B) may be the main reason of the deficit in affective decision‐making, while that in patients with MDD was a significantly decreased ability to choose advantageous decks on the whole but with larger‐magnitude less frequent punishments (deck D). As regards patients with BD, the concurrence of more choices of deck B and fewer choices of deck D was the characteristic of the deficit in affective decision‐making. Our findings suggest a common affective decision‐making impairment in the context of multiple choices in patients with SCZ, MDD, and BD, while the underlying mechanisms of the impairment among these patients may be slightly different.
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Decision-making and learning impairments are core characteristics of a wide range of psychiatric disorders, including MDD, OCD, and schizophrenia, and are linked to their specific symptoms.
“Decision-making and learning impairments are core characteristics of a wide range of psychiatric disorders — such as major depressive disorder (MDD), obsessive–compulsive disorder (OCD), and schizophrenia — and are linked to their specific symptoms.1–9”
From Investigating disorder-specific and transdiagnostic alterations in model-based and model-free decision-making (2024) · cites this paper as [3]
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
A Rating Scale for Mania: Reliability, Validity and Sensitivity
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.5.429 · Cited by 8,744 · see citing works
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067 · see citing works
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128 · see citing works
Emotion, Decision Making and the Orbitofrontal Cortex
Bechara, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.295 · Cited by 3,589 · see citing works
Deciding advantageously before knowing the advantageous strategy
Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1997) · Science · doi:10.1126/science.275.5304.1293 · Cited by 3,547 · see citing works
Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making
Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05473.1999 · Cited by 2,001 · see citing works
Developing constructs for psychopathology research: Research domain criteria
Sanislow, C. A., Pine, D. S., Quinn, K. J., Kozak, M. J., Garvey, M. A., Heinssen, R. K., Wang, P. S.-E., & Cuthbert, B. N. (2010) · Journal of Abnormal Psychology · doi:10.1037/a0020909 · Cited by 793 · see citing works
Treadway, M. T., Buckholtz, J. W., Schwartzman, A. N., Lambert, W. E., & Zald, D. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006598 · Cited by 769 · see citing works
Waltz, J. A., & Gold, J. M. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.03.010 · Cited by 331 · see citing works
Barch, D. M., Treadway, M. T., & Schoen, N. (2014) · Journal of Abnormal Psychology · doi:10.1037/a0036299 · Cited by 323 · see citing works
Yang, X.-H., Huang, J., Zhu, C.-Y., Wang, Y.-F., Cheung, E. F. C., Chan, R. C. K., & Xie, G.-R. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.08.056 · Cited by 288 · see citing works
Self-citationNusslock, R., Almeida, J., Forbes, E. E., Versace, A., Frank, E., LaBarbara, E. J., Klein, C. R., & Phillips, M. L. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01012.x · Cited by 238 · see citing works
Shurman, B., Horan, W. P., & Nuechterlein, K. H. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.03.020 · Cited by 237 · see citing works
Distinct Roles of Prefrontal Cortical Subregions in the Iowa Gambling Task
Lawrence, N., Jollant, F., O’Daly, O., Zelaya, F. O., & Phillips, M. L. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn154 · Cited by 231 · see citing works
Sensitivity to reward and punishment and the prefrontal cortex in major depression
Must, A., Szabó, Z., Bódi, N., Szász, A., Janka, Z., & Kéri, S. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.12.005 · Cited by 218 · see citing works
Decision-making and risk aversion among depressive adults
Smoski, M. J., Lynch, T. R., Rosenthal, M. Z., Cheavens, J. S., Chapman, A. L., & Krishnan, R. R. (2008) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2008.01.004 · Cited by 198 · see citing works
Impaired flexible decision-making in major depressive disorder
Cella, M., Dymond, S., & Cooper, A. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.11.013 · Cited by 192 · see citing works
Affective decision making: A theory of optimism bias
Bracha, A., & Brown, D. J. M. (2012) · Games Econ. Behav. · doi:10.1016/j.geb.2011.11.004 · Cited by 176 · see citing works
Defective somatic markers in sub-clinical psychopathy
van Honk, J., Hermans, E. J., Putman, P., Montagne, B., & Schutter, D. J. L. G. (2002) · Neuroreport · doi:10.1097/00001756-200206120-00009 · Cited by 158 · see citing works
Trait-Related Decision-Making Impairment in the Three Phases of Bipolar Disorder
Adida, M., Jollant, F., Clark, L., Besnier, N., Guillaume, S., Kaladjian, A., Mazzola‐Pomietto, P., Jeanningros, R., Goodwin, G. M., Azorin, J., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.018 · Cited by 145 · see citing works
Waltz, J. A., Kasanova, Z., Ross, T. J., Salmeron, B. J., McMahon, R. P., Gold, J. M., & Stein, E. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057257 · Cited by 122 · see citing works
Ciccarelli, M., Griffiths, M. D., Nigro, G., & Cosenza, M. (2016) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2016.08.012 · Cited by 120 · see citing works
Johnson, C. A., Xiao, L., Palmer, P. H., Sun, P., Wang, Q., Wei, Y., Jia, Y., Grenard, J. L., Stacy, A. W., & Bechara, A. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.09.012 · Cited by 117 · see citing works
Processes Underlying Depression: Risk Aversion, Emotional Schemas, and Psychological Flexibility
Leahy, R. L., Tirch, D. D., & Melwani, P. S. (2012) · International Journal of Cognitive Therapy · doi:10.1521/ijct.2012.5.4.362 · Cited by 99 · see citing works
Ursu (2009) · doi:10.1016/j.neuropsychologia.2009.04.003 · Cited by 91 · see citing works
Decision making in euthymic bipolar I and bipolar II disorders
Martino, D. J., Strejilevich, S., Torralva, T., & Manes, F. F. (2010) · Psychological Medicine · doi:10.1017/s0033291710001832 · Cited by 90 · see citing works
Frangou, S., Kington, J., Raymont, V., & Shergill, S. S. (2007) · European Psychiatry · doi:10.1016/j.eurpsy.2007.05.002 · Cited by 84 · see citing works
Neural substrates of the impaired effort expenditure decision making in schizophrenia.
Huang, J., Yang, X., Lan, Y., Cui-ying, Z., Liu, X.-Q., Wang, Y., Cheung, E. F. C., Xie, G., & Chan, R. C. K. (2016) · Neuropsychology · doi:10.1037/neu0000284 · Cited by 70 · see citing works
Self-citationPaquet, A., Olliac, B., Golse, B., & Vaivre‐Douret, L. (2018) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2018.1483486 · Cited by 68 · see citing works
Brambilla, P., Perlini, C., Bellani, M., Tomelleri, L., Ferro, A., Cerruti, S., Marinelli, V., Rambaldelli, G., Christodoulou, T., Jogia, J., et al. (2012) · Psychological Medicine · doi:10.1017/s0033291712001304 · Cited by 61 · see citing works
Deisenhammer, E., Schmid, S., Kemmler, G., Moser, B., & Delazer, M. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.10.012 · Cited by 60 · see citing works
A further evaluation of decision-making under risk and under ambiguity in schizophrenia
Fond, G. B., Bayard, S., Capdevielle, D., Del-Monte, J., Mimoun, N., Macgregor, A., Boulenger, J., Gély-Nargeot, M.-C., & Raffard, S. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0330-y · Cited by 59 · see citing works
Brown, E. C., Hack, S. M., Gold, J. M., Carpenter, W. T., Fischer, B. A., Prentice, K. J., & Waltz, J. A. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.007 · Cited by 58 · see citing works
Disrupted cortico‐limbic connectivity during reward processing in remitted bipolar I disorder
Dutra, S. J., Man, V. Y., Hedy Kober, A., Cunningham, W. A., & Gruber, J. (2017) · Bipolar Disorders · doi:10.1111/bdi.12560 · Cited by 57 · see citing works
Depressive Decision Making: Validation of the Portfolio Theory Model
Leahy, R. L. (2001) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.15.4.341 · Cited by 52 · see citing works
Ono, Y., Kikuchi, M., Hirosawa, T., Hino, S., Nagasawa, T., Hashimoto, T., Munesue, T., & Minabe, Y. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.04.003 · Cited by 52 · see citing works
‘Cool’ and ‘Hot’ executive functions in suicide attempters with major depressive disorder
Ho, M., Hsu, Y.-C., Lu, M., Gossop, M., & Chen, V. C. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.04.057 · Cited by 51 · see citing works
Brown, J. K., Waltz, J. A., Strauss, G. P., McMahon, R. P., Frank, M. J., & Gold, J. M. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.02.034 · Cited by 45 · see citing works
Risky decision-making under risk in schizophrenia: A deliberate choice?
Pedersen, A., Göder, R., Tomczyk, S., & Ohrmann, P. (2016) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2016.08.004 · Cited by 44 · see citing works
Reward-driven decision-making impairments in schizophrenia
Saperia, S., Da Silva, S., Siddiqui, I., Agid, O., Daskalakis, Z. J., Ravindran, A., Voineskos, A. N., Zakzanis, K. K., Remington, G., & Foussias, G. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2018.11.004 · Cited by 41 · see citing works
Working Memory in the Processing of the Iowa Gambling Task: An Individual Differences Approach
Bagneux, V., Thomassin, N., Gonthier, C., & Roulin, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081498 · Cited by 40 · see citing works
Emotion and decision-making: Induced mood influences IGT scores and deck selection strategies
Shukla, M., Rasmussen, E. C., & Nestor, P. G. (2019) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2018.1562049 · Cited by 37 · see citing works
Iowa gambling task performance in euthymic bipolar I disorder: A meta-analysis and empirical study
Edge, M. D., Johnson, S. L., Ng, T. H., & Carver, C. S. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.027 · Cited by 34 · see citing works
Damme, K. S. F., Young, C. B., & Nusslock, R. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx017 · Cited by 32 · see citing works
Njomboro, P., & Deb, S. S. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00073 · Cited by 18 · see citing works
Characterization of Risk-Taking in Adults With Bipolar Spectrum Disorders
Reinharth, J., Braga, R. J., & Serper, M. R. (2017) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000680 · Cited by 17 · see citing works
Neuropsychology of reward learning and negative symptoms in schizophrenia
Nestor, P. G., Choate, V. R., Niznikiewicz, M. A., Levitt, J. J., Shenton, M. E., & McCarley, R. W. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.08.028 · Cited by 16 · see citing works
Moniz, M., de Jesús, S. N., Gonçalves, E., Pacheco, A., & Viseu, J. N. R. (2016) · Neuropsychological Trends · doi:10.7358/neur-2016-019-moni · Cited by 15 · see citing works
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Mestre‐Bach, G., Fernández‐Aranda, F., Jiménez‐Múrcia, S., & Potenza, M. N. (2020) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-020-00212-7 · Cited by 25 · see citing works
Husain, S. F., Ong, S. K., Liu, C., Tran, B. X., Ho, R., & Ho, C. S. H. (2020) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420976856 · Cited by 23 · see citing works
Risky decision-making in major depressive disorder: A three-level meta-analysis
Lu, J., Zhao, X., Wei, X., & He, G. (2023) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2023.100417 · Cited by 20 · see citing works
Fan, L., Kong, X., Zhang, P., Lin, P., Zhao, J., Ji, X., Fang, S., Wang, X., Yao, S., Li, H., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.019 · Cited by 18 · see citing works
Wu, Y. F., Wang, L., Yu, F., Ji, G., Xiao, G., Xu, F., Chunyan, Z., Chen, X., & Wang, K. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.594102 · Cited by 13 · see citing works
Knolle, F., Sen, P., Culbreth, A., Koch, K., Schmitz-Koep, B., Gürsel, D. A., Wunderlich, K., Avram, M., Berberich, G., Sorg, C., et al. (2024) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.240020 · Cited by 9 · see citing works
Miranda, A. H., Roberts, B. Z., Holloway, B. M., Peek, E. M., Rosberg, H., Ayoub, S. M., Piomelli, D., Jung, K., Barnes, S. A., Rossi, S. S., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03718-4 · Cited by 5 · see citing works
Ramírez‐Martín, A., Sirignano, L., Streit, F., Foo, J. C., Forstner, A. J., Frank, J., Nöthen, M. M., Strohmaier, J., Witt, S. H., Mayoral, F., et al. (2023) · Brain and Behavior · doi:10.1002/brb3.3337 · Cited by 6 · see citing works
Wang, L., Wang, J., Liu, B.-H., Tuo, D., Lui, S. S. Y., Wan, W., Huang, J., & Chan, R. C. K. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114979 · Cited by 2 · see citing works
Transdiagnostic study of mental disorders
Chan, R. C. K., Barkus, E., & Sun, H. (2020) · PsyCh Journal · doi:10.1002/pchj.357 · Cited by 1 · see citing works
- Authors
- Gu, Y., Zhou, C., Yang, J., Zhang, Q., Zhu, G., Sun, L., Ge, M., & Wang, Y.
- Affiliations
- Department of Psychology Weifang Medical University Weifang China
- Weifang Medical University (CN)
- Department of Psychiatry Mental Health Centre of Weifang City Weifang China
- Centre for Depression Therapy, Mental Health Centre of Weifang City Weifang China
- Venue
- PsyCh Journal
- Publisher
- Wiley
- Published
- 2020-02-19
- Volume
- 9
- Issue
- 2
- Pages
- 199-209
- ISSN
- 2046-0252 (ISSN-L)
- 2046-0260
- OpenAlex
- W3006741106
- Cited by
- 11
- References
- 52
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PsyCh Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the Humanities and Social Science Research Project, Ministry of Education, China (19YJA190006)
- the Natural Science Foundation of Shandong Province (ZR2017LC023)
- the Postgraduate Tutor Guidance Ability Improvement Project of Shandong Province (SDYY18148)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- emotional decision-making, decision-making deficits, schizophrenia, major depressive disorder, bipolar disorder, Iowa Gambling Task, punishment sensitivity, reward sensitivity
- MeSH terms
- Adult, Bipolar Disorder, Decision Making, Major Depressive Disorder, Depressive Disorder, Major, Female, Gambling, Humans, Male, Neuropsychological Tests, Patients, Schizophrenia
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