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Cited by 115Pregnancy and preeclampsia studiesPrenatal Screening and DiagnosticsMaternal and Neonatal Healthcare

Reference range of birth weight with gestation and first-trimester prediction of small-for-gestation neonates

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Poon, Leona C. Y., Karagiannis, George, Staboulidou, Ismini, Shafiei, Akram, Nicolaides, Kypros H.·2011·Prenatal Diagnosis
DOI 10.1002/pd.2520
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Abstract

OBJECTIVE: Firstly, to establish a reference range of birth weight with gestation at delivery; secondly, to identify maternal characteristics that are significantly associated with birth weight; and thirdly, to determine if combinations of maternal characteristics, fetal nuchal translucency thickness (NT), and serum concentrations of free beta-human chorionic gonadotrophin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) are significant predictors of small-for-gestational-age (SGA) neonates in the absence of preeclampsia. METHOD: Maternal characteristics were recorded; fetal NT, maternal serum free β-hCG and PAPP-A were measured at 11 weeks to 13 weeks 6 days in 33,602 women with singleton pregnancies. Regression analysis was used to determine the association of birth weight with gestation at delivery and to establish a reference range with gestation. Logistic regression analysis was used to determine if maternal factors, fetal NT, free β-hCG, and PAPP-A contribute significantly in predicting SGA in the absence of preeclampsia. RESULTS: Birth weight increased with maternal weight and height; it was higher in parous than in nulliparous women and in those with a medical history of pre-pregnancy diabetes mellitus, and it was lower in cigarette smokers, in all racial groups other than in Caucasian women, and in those with a medical history of chronic hypertension and in those who previously delivered SGA neonates. In the SGA group compared with the unaffected group, there were lower median delta NT (0.10 vs 0.12 mm), free β-hCG [0.9 vs 1.0 MoM (multiples of median)], and PAPP-A (0.8 vs 1.0 MoM). The prediction of SGA provided by maternal factors was significantly improved by the addition of fetal NT and PAPP-A (34.0 vs 37.0% at a false-positive rate of 10%). CONCLUSION: Prediction of the birth of SGA neonates in the absence of preeclampsia can be provided in the first trimester of pregnancy by a combination of maternal characteristics and measurements of parameters used in early screening for aneuploidies.

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Authors
Poon, L. C. Y., Karagiannis, G., Staboulidou, I., Shafiei, A., & Nicolaides, K. H.
Affiliations
Harris Birthright Research Centre for Fetal Medicine (GB)
Corresponding author
Nicolaides, Kypros H.
ORCID
Venue
Prenatal Diagnosis
Publisher
Wiley
Published
2010-08-26
Volume
31
Issue
1
Pages
58-65
ISSN
  • 0197-3851 (ISSN-L)
  • 1097-0223
DOI
10.1002/pd.2520
OpenAlex
W2153459377
Cited by
115
References
30
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 7 · 2021: 6 · 2020: 10 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 12 · 2012: 21
FWCI
25.31
Type
journal article
Language
en
Open access
Licence
Locations
  • Prenatal Diagnosis (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, other-oa)
Funders
Fetal Medicine Foundation
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
Keywords
small for gestational age, first-trimester prediction, nuchal translucency, PAPP-A, maternal risk factors, preeclampsia, preimplantation genetic testing for aneuploidy, singleton pregnancy, maternal smoking, maternal diabetes, chronic hypertension
MeSH terms
Adult, Birth Weight, Body Height, Body Weight, Female, Gestational Age, Humans, Infant, Newborn, Infant, Small for Gestational Age, Pregnancy, Pregnancy-Associated Plasma Protein-A, Prenatal Diagnosis, Prospective Studies, Reference Values, Logistic Models, Chorionic Gonadotropin, beta Subunit, Human, Nuchal Translucency Measurement

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