Cited by 249Schizophrenia research and treatmentSuicide and Self-Harm StudiesMental Health and Psychiatry

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Mortality in schizophrenia.

Auquier, Pascal, Lançon, Christophe, Rouillon, Frédéric, Lader, Malcolm, Holmes, Catriona·2006·Pharmacoepidemiology and Drug Safety

DOI 10.1002/pds.1325

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Abstract

PURPOSE: The purpose of this article is to describe the current status of knowledge on excess mortality in schizophrenia and its causative factors, and to expand upon previous work evaluating approaches that may reduce mortality rates. METHODS: Literature available since 1995 was identified in a computerized search of the bibliographical databases Medline and Embase, using the topics 'mortality' and 'schizophrenia', and in a cross-reference search for articles that were particularly relevant. RESULTS: Schizophrenia is associated with mortality rates that are two to three times higher than those expected or observed in the general population. This excess of mortality is accounted for by a combination of an increased risk of suicide, in particular in young male patients soon after diagnosis, and more importantly, a higher number of natural deaths. In order to diminish the level of suicide among people with schizophrenia, the majority of research has focused on the identification of risk factors that predispose patients to attempt or commit suicide, while unhealthy styles, polypharmacy and inadequate healthcare have been shown to contribute to the high natural mortality. The link between the use of antipychotics and mortality has not been yet clarified. CONCLUSION: Dramatically increased mortality of schizophrenia patients is well established. It is time to move beyond this topic, and work towards interventions that aim at reducing the mortality risk in such patients.

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“This excess of mortality is accounted by a combination of an increased risk of suicide, and more importantly, a higher number of natural deaths (Auquier et al., 2006).”
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“Although severity of schizophrenia has not been reported [3] to be a risk factor for death, high mortality rates can be expected in Kraepelinian schizophrenia.”
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“This excess premature mortality is represented by a higher number of natural causes of death (such as medical diseases, unhealthy lifestyle, substance misuse, poor compliance or treatment refusal, untreated somatic conditions, and adverse effects of psychotropic medications) and a significant number of unnatural cause…”
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The long-term effects of a 24-week outdoor exercise program in persons with schizophrenia: Results of a 12-week follow-up period
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Authors: Auquier, P., Lançon, C., Rouillon, F., Lader, M., & Holmes, C.
Affiliations: Hôpital de la Timone (FR)
Hôpital Sainte-Marguerite (FR)
Centre Hospitalier Sainte-Anne (FR)
Corresponding author: Auquier, Pascal
ORCID: Auquier, Pascal
Lançon, Christophe
Venue: Pharmacoepidemiology and Drug Safety
Publisher: Wiley
Published: 2006-10-23
Volume: 15
Issue: 12
Pages: 873-879
ISSN: 1053-8569 (ISSN-L)
1099-1557
DOI: 10.1002/pds.1325
OpenAlex: W2097031522
Cited by: 249
References: 77
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 20 · 2012: 27
FWCI: 3.19
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Pharmacoepidemiology and Drug Safety (publishedVersion)
PubMed (publishedVersion)
Funders: H. Lundbeck A/S
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, excess mortality, suicide risk, natural mortality, risk factors, polypharmacy, antipsychotic drugs, quality of care
MeSH terms: Cardiovascular Diseases, Cause of Death, Health Services Accessibility, Humans, Risk, Schizophrenia, Suicide, Antipsychotic Agents, Violence, Harm Reduction

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