The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Mortality in schizophrenia.
Abstract
PURPOSE: The purpose of this article is to describe the current status of knowledge on excess mortality in schizophrenia and its causative factors, and to expand upon previous work evaluating approaches that may reduce mortality rates. METHODS: Literature available since 1995 was identified in a computerized search of the bibliographical databases Medline and Embase, using the topics 'mortality' and 'schizophrenia', and in a cross-reference search for articles that were particularly relevant. RESULTS: Schizophrenia is associated with mortality rates that are two to three times higher than those expected or observed in the general population. This excess of mortality is accounted for by a combination of an increased risk of suicide, in particular in young male patients soon after diagnosis, and more importantly, a higher number of natural deaths. In order to diminish the level of suicide among people with schizophrenia, the majority of research has focused on the identification of risk factors that predispose patients to attempt or commit suicide, while unhealthy styles, polypharmacy and inadequate healthcare have been shown to contribute to the high natural mortality. The link between the use of antipychotics and mortality has not been yet clarified. CONCLUSION: Dramatically increased mortality of schizophrenia patients is well established. It is time to move beyond this topic, and work towards interventions that aim at reducing the mortality risk in such patients.
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“Long-term antipsychotic use and adverse lifestyle choices (e.g. obesity, smoking, poor diet, illicit drug use, and physical inactivity) are implicated in increased risk of cardiovascular events in these populations [3], [19], [20], [22], [31]–[33]”
From Life Expectancy at Birth for People with Serious Mental Illness and Other Major Disorders from a Secondary Mental Health Care Case Register in London (2011) · cites this paper as [19]
Citations
Cites
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“The syndrome has been associated with an increased risk for cardiovascular morbidity and mortality.(25,26) Patients with schizophrenia would seem to have a two-fold higher relative risk of developing coronary heart disease (CHD) compared with the general population.”
BackgroundDiscovering the Neural Basis of Human Social Anxiety: A Diagnostic and Therapeutic Imperative
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.1 · Cited by 1,428
Research works printed but not linked: 1
- Casey DE, 2004, Antipsychotic‐induced weight gain and metabolic abnormalities: implications for increased mortality in patients with schizophrenia, J Clin Psychiatry, 65, 4
Cited by
Sorted by citations
Schizophrenia, “just the facts” 4. Clinical features and conceptualization
Tandon, R., Nasrallah, H. A., & Keshavan, M. S. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.005 · Cited by 1,101
“Age-standardized mortality rates among persons with schizophrenia are approximately double that of the general population and their lifespan is abbreviated by approximately 15–20 years (Parks et al., 2006; Auquier et al., 2007).”
Chang, C.-K., Hayes, R. D., Perera, G., Broadbent, M. T. M., Fernandes, A. C., Lee, W. E., Hotopf, M., & Stewart, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019590 · Cited by 714
“Preliminary strategies for preventing premature deaths among people with SMI have been suggested, emphasizing the management of suicide risk and physical illness, minimum polypharmacy, and improvement of accessibility to physical health care [19].”
BackgroundBarnes, T. R. E., Drake, R., Paton, C., Cooper, S. J., Deakin, J. F. W., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I. R., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 615
Correll, C. U., Rummel-Kluge, C., Corves, C., Kane, J. M., & Leucht, S. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn018 · Cited by 406
Schizophrenia, neuroleptic medication and mortality
Joukamaa, M., Heliövaara, M., Knekt, P., Aromaa, A., Raitasalo, R., & Lehtinen, V. (2006) · British Journal of Psychiatry · doi:10.1192/bjp.188.2.122 · Cited by 395
Metadata
- Authors
- Auquier, P., Lançon, C., Rouillon, F., Lader, M., & Holmes, C.
- Affiliations
- Hôpital de la Timone (FR)
- Hôpital Sainte-Marguerite (FR)
- Centre Hospitalier Sainte-Anne (FR)
- Corresponding author
- Auquier, Pascal
- Venue
- Pharmacoepidemiology and Drug Safety
- Publisher
- Wiley
- Published
- 2006-10-23
- Volume
- 15
- Issue
- 12
- Pages
- 873-879
- ISSN
- 1053-8569 (ISSN-L)
- 1099-1557
- OpenAlex
- W2097031522
- Cited by
- 249
- References
- 77
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 20 · 2012: 27
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacoepidemiology and Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- Funders
- H. Lundbeck A/S
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, excess mortality, suicide risk, natural mortality, risk factors, polypharmacy, antipsychotic drugs, quality of care
- MeSH terms
- Cardiovascular Diseases, Cause of Death, Health Services Accessibility, Humans, Risk, Schizophrenia, Suicide, Antipsychotic Agents, Violence, Harm Reduction
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