The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Antimicrobial peptides under clinical investigation
Abstract
Overuse of conventional antibiotics as well as the slow pace of new antibiotic drug development leads to antimicrobial resistance (AMR). Because infections with multi‐drug resistant (MDR) pathogens have become a public health issue, the need for a novel class of antibiotics is urgent. Recently, antimicrobial peptides (AMPs) have emerged as a promising platform to fight against MDR bacteria ensuring broad‐spectrum antimicrobial activity and relatively low resistance emergence. Currently, a number of AMPs are undergoing clinical and preclinical trials against various infectious diseases. This review lists the 36 AMPs (27 clinical and 9 preclinical) with brief information about their origin, structure, mechanism, and development status. From the examples of AMPs under clinical investigation, we categorized several improvement strategies and highlighted directions for the future design of AMPs.
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Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Antimicrobial resistance: a global multifaceted phenomenon
Prestinaci, F., Pezzotti, P., & Pantosti, A. (2015) · Pathogens and Global Health · doi:10.1179/2047773215y.0000000030 · Cited by 3,296
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834
Therapeutic peptides: Historical perspectives, current development trends, and future directions
Lau, J. L., & Dunn, M. K. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.06.052 · Cited by 1,879
Park, S.-C., Park, Y., & Hahm, K.-S. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12095971 · Cited by 327
Cited by
Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities
Luo, Y., & Song, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111401 · Cited by 559
Greco, I., Molchanova, N., Holmedal, E., Jenssen, H., Hummel, B. D., Watts, J. L., Håkansson, J., Hansen, P. R., & Svenson, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-69995-9 · Cited by 441
Mode-of-Action of Antimicrobial Peptides: Membrane Disruption vs. Intracellular Mechanisms
Benfield, A. H., & Henriques, S. T. (2020) · Frontiers in Medical Technology · doi:10.3389/fmedt.2020.610997 · Cited by 367
Antimicrobial peptides towards clinical application: Delivery and formulation
Wang, C., Hong, T., Cui, P., Wang, J., & Xia, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.028 · Cited by 281
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
Jiang, Y., Chen, Y., Song, Z., Tan, Z., & Cheng, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.016 · Cited by 267
Metadata
- Authors
- Koo, H. B., & Seo, J.
- Venue
- Peptide Science
- Publisher
- Wiley
- Published
- 2019-06-03
- Volume
- 111
- Issue
- 5
- ISSN
- 2475-8817 (ISSN-L)
- OpenAlex
- W2948285055
- Cited by
- 376
- References
- 5
- FWCI
- 29.85
- Type
- journal article
- Language
- en
- Open access
- closed
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