The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Antimicrobial peptides towards clinical application: Delivery and formulation
Abstract
Antimicrobial peptides hold promise to supplement small molecules antibiotics and combat the multidrug resistant microbes. There are however technical hurdles towards the clinical applications, largely due to the inherent limitations of peptides including stability, cytotoxicity and bioavailability. Here we review recent studies concerning the delivery and formulation of antimicrobial peptides, by categorizing the different strategies as driven by physical interactions or chemical conjugation reactions, and carriers ranging from inorganic based ones (including gold, silver and silica based solid nanoparticles) to organic ones (including micelle, liposome and hydrogel) are covered. Besides, targeted delivery of antimicrobial peptides or using antimicrobial peptides as the targeting moiety, and responsive release of the peptides after delivery are also reviewed. Lastly, strategies towards the increase of oral bioavailability, from both physical or chemical methods, are highlighted. Altogether, this article provides a comprehensive review of the recent progress of the delivery and formulation of antimicrobial peptides towards clinical application.
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Cites
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The value of antimicrobial peptides in the age of resistance
Magana, M., Pushpanathan, M., Santos, A. L., Leanse, L., Fernandez, M., Ioannidis, A., Giulianotti, M. A., Apidianakis, Y., Bradfute, S., Ferguson, A. L., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30327-3 · Cited by 1,150
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application
Naseri, N., Valizadeh, H., & Zakeri-Milani, P. (2015) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2015.043 · Cited by 1,116
Mesoporous Silica Nanoparticles for Drug Delivery
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Biomimetic peptide self-assembly for functional materials
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Toxicity of polymyxins: a systematic review of the evidence from old and recent studies
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Antimicrobial Peptides: Mechanisms of Action and Resistance
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Cited by
Antimicrobial peptides: Structure, mechanism, and modification
Chen, N., & Jiang, C. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115377 · Cited by 279
Metadata
- Authors
- Wang, C., Hong, T., Cui, P., Wang, J., & Xia, J.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 175
- Pages
- 113818
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W3172532482
- Cited by
- 281
- References
- 116
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
