Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum
Abstract
The present study has been designed to investigate the protective effect of L-theanine against 3-nitropropionic acid (3-NP)-induced Huntington's disease (HD)-like symptoms in rats. The present experimental protocol design includes systemic 3-NP acid (10 mg/kg intraperitonially) treatment for 14 d. L-theanine (100 and 200 mg/kg) was given orally, once a day, 1 h before 3-NP acid treatment for 14 d. Body weight and behavioral parameters (Morris water maze, open field test (OFT), forced swim test (FST) and rotarod activity) were assessed on 1st, 5th, 10th and 15th day post-3-NP acid administration. Malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) levels and mitochondrial enzyme complex. Succinate dehydrogenase (SDH) were measured on the 15th day in the striatum. Systemic 3-NP acid treatment significantly reduced body weight, locomotor activity and oxidative defense. The mitochondrial enzyme activity was also significantly impaired in the striatum region in 3-NP acid-treated animals. L-theanine (100 and 200 mg/kg b.wt.) treatment significantly attenuated the impairment in behavioral, biochemical and mitochondrial enzyme activities as compared to the 3-NP acid-treated group. The results of the present study suggest that pretreatment with L-theanine significantly attenuated 3-NP induced oxidative stress and restored the decreased SOD, GSH, CAT and SDH activity. It also decreased the neuronal damage as evidenced by histopathological analysis of striatum. Based on the above study, it has been proved that L-theanine has neuroprotective activity against 3-NP induced neurotoxicity.
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Recent studies report an anxiolytic effect of a single dose of theanine up to 200-250 mg per day, and it may be extended up to 1250 mg/day.
“Recent studies referred anxiolytic effect of single dose of theanine up to 200-250 mg per day and it may be extended up to 1 250 mg/day [9,12,[35][36][37] .”
From l -theanine: A potential multifaceted natural bioactive amide as health supplement (2017) · cites this paper as [36]
Theanine protects neural damage and improves function by reducing cerebral infarction through inhibiting catalase, superoxide dismutase, and succinate dehydrogenase activity, thus reducing GSH and oxidative damage of neuronal cells.
“Theanine helps to protect neural damage and improve function by reduction of cerebral infarction by inhibiting different neurological functions like catalase, superoxide dismutase, and succinate dehydrogenase (SDH) activity, thus reduces GSH and oxidative damage of neuronal cells [36][37][38] .”
From l -theanine: A potential multifaceted natural bioactive amide as health supplement (2017) · cites this paper as [36]
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- Authors
- Thangarajan, S., Deivasigamani, A., Natarajan, S. S., Krishnan, P., & Mohanan, S. K.
- Affiliations
- University of Madras (IN)
- Venue
- International Journal of Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2014-01-23
- Volume
- 124
- Issue
- 9
- Pages
- 673-684
- ISSN
- 0020-7454 (ISSN-L)
- 1543-5245
- OpenAlex
- W2107972568
- Cited by
- 71
- References
- 54
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 2 · 2020: 8 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 10 · 2015: 7 · 2014: 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- theanine, neuroprotection, 3-nitropropionic acid, Huntington's disease model, striatum, oxidative stress, mitochondrial dysfunction, succinate dehydrogenase, antioxidant enzymes, locomotor impairment, neurotoxicity
- MeSH terms
- Animals, Body Weight, Brain, Catalase, Convulsants, Corpus Striatum, Exploratory Behavior, Glutamates, Glutathione, Male, Mitochondria, Motor Activity, Nitro Compounds, Propionates, Superoxide Dismutase, Lipid Peroxidation, Rats, Wistar, Neuroprotective Agents, Maze Learning, Neurotoxicity Syndromes, Rats
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