The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Garcinia mangostana L.: a phytochemical and pharmacological review
Abstract
Garcinia mangostana L. (mangosteen, Clusiaceae) has a long history of use as a medical plant, mostly in Southeast Asia. This is a review of the phytochemistry and pharmacology of mangosteen. Traditionally mangosteen is famous for its antiinflammatory properties and is used in the treatment of skin infections and wounds. Other applications include the therapy of various conditions such as dysentery, different urinary disorders, cystitis and gonorrhoea. This review highlights the development of this botanical drug into a widely used nutraceutical. Products derived from G. mangostana are now distributed increasingly all over the world. This has given rise to a concomitant increase in research on the phytochemical constituents and biological activity of mangosteen. Central to the biological activity of the species are xanthones which are reviewed in detail. A comprehensive assessment of the biological activities of individual xanthones as well as extracts of G. mangostana is included. In addition, its potential in terms of developing novel drug leads is assessed. Products containing its fruits are now sold widely as ‘liquid botanical supplements’, but evidence for the health benefits of these products is still lacking. As shown here, a serious weakness in our knowledge is the lack of clinical data and it is not yet clear to what extent the findings about pharmacological activities are of potential clinical relevance. Copyright © 2009 John Wiley & Sons, Ltd.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
Corson, T. W., & Crews, C. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.021 · Cited by 654
Antioxidant Xanthones from the Pericarp of Garcinia mangostana (Mangosteen)
Jung, H.-A., Su, B.-N., Keller, W. J., Mehta, R. G., & Kinghorn, A. D. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052649z · Cited by 512
Xanthone Derivatives: New Insights in Biological Activities
Pinto, M. M. M., Sousa, M. E., & Nascimento, M. S. J. (2005) · Current Medicinal Chemistry · doi:10.2174/092986705774370691 · Cited by 481
Plant-Derived Leading Compounds for Chemotherapy of Human Immunodeficiency Virus (HIV) Infection
Vlietinck, A., De Bruyne, T., Apers, S., & Pieters, L. (1998) · Planta Medica · doi:10.1055/s-2006-957384 · Cited by 417
Tetraoxygenated naturally occurring xanthones
Peres, V., Nagem, T. J., & de Oliveira, F. F. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00303-4 · Cited by 402
Anti-inflammatory activity of mangostins from Garcinia mangostana
Chen, L.-G., Yang, L.-L., & Wang, C.-C. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.096 · Cited by 388
Moongkarndi, P., Kosem, N., Kaslungka, S., Luanratana, O., Pongpan, N., & Neungton, N. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.09.048 · Cited by 348
Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria
Chomnawang, M. T., Surassmo, S., Nukoolkarn, V. S., & Gritsanapan, W. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.04.038 · Cited by 305
Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana
Suksamrarn, S., Suwannapoch, N., Phakhodee, W., Thanuhiranlert, J., Ratananukul, P., Chimnoi, N., & Suksamrarn, A. (2003) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.51.857 · Cited by 261
Food as medicine and medicine as food
Etkin, N. L., & Ross, P. J. (1982) · Social Science & Medicine · doi:10.1016/0277-9536(82)90167-8 · Cited by 249
Cytotoxic Prenylated Xanthones from the Young Fruit of Garcinia mangostana
Suksamrarn, S., Komutiban, O., Ratananukul, P., Chimnoi, N., Lartpornmatulee, N., & Suksamrarn, A. (2006) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.54.301 · Cited by 240
Chemical Constituents of Garcinia mangostana
Mahabusarakam, W., Wiriyachitra, P., & Taylor, W. C. (1987) · Journal of Natural Products · doi:10.1021/np50051a021 · Cited by 222
Naturally-Occurring Xanthones: Recent Developments
Vieira, L. M. M., & Kijjoa, A. (2005) · Current Medicinal Chemistry · doi:10.2174/092986705774370682 · Cited by 201
Preferential target is mitochondria in α-mangostin-induced apoptosis in human leukemia HL60 cells
Matsumoto, K., Akao, Y., Yi, H., Ohguchi, K., Ito, T., Tanaka, T., Kobayashi, E., Iinuma, M., & Nozawa, Y. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.08.034 · Cited by 188
Nakatani, K., Nakahata, N., Arakawa, T., Yasuda, H., & Ohizumi, Y. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00810-3 · Cited by 146
Phenolics from hull of Garcinia mangostana fruit and their antioxidant activities
Yu, L., Zhao, M., Yang, B. J., Zhao, Q., & Jiang, Y. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2006.11.018 · Cited by 143
Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line
Moongkarndi, P., Kosem, N., Luanratana, O., et al. (2004) · Fitoterapia · doi:10.1016/j.fitote.2004.01.010 · Cited by 143
Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes
Chomnawang, M. T., Surassmo, S., Nukoolkarn, V. S., et al. (2007) · Fitoterapia · doi:10.1016/j.fitote.2007.02.019 · Cited by 140
Chin, Y., Jung, H., Chai, H., Keller, W. J., & Kinghorn, A. D. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.09.023 · Cited by 140
Active Constituents Against HIV-1 Protease fromGarcinia mangostana
Chen, S., Wan, M. T., & Loh, B. (1996) · Planta Medica · doi:10.1055/s-2006-957916 · Cited by 132
Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin
Mahabusarakam, W., Proudfoot, J. M., Taylor, W. C., & Croft, K. D. (2000) · Free Radical Research · doi:10.1080/10715760000301161 · Cited by 126
HPLC analysis of selected xanthones in mangosteen fruit
Walker, E. B. (2007) · Journal of Separation Science · doi:10.1002/jssc.200700024 · Cited by 125
Ji, X., Avula, B., & Khan, I. A. (2006) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2006.10.018 · Cited by 121
Voravuthikunchai, S. P., & Kitpipit, L. (2005) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2005.01104.x · Cited by 120
Mangostin Inhibits the Oxidative Modification of Human Low Density Lipoprotein
Williams, P. D., Ongsakul, M., Proudfoot, J. M., Croft, K. D., & Beilin, L. J. (1995) · Free Radical Research · doi:10.3109/10715769509064030 · Cited by 116
Nakatani, K., Yamakuni, T., Kondo, N., Arakawa, T., Oosawa, K., Shimura, S., Inoue, H., & Ohizumi, Y. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.002626 · Cited by 105
Xanthones as Antimalarial Agents: Discovery, Mode of Action, and Optimization
Riscoe, M. K., Kelly, J. X., & Winter, R. W. (2005) · Current Medicinal Chemistry · doi:10.2174/092986705774370709 · Cited by 102
Xanthones from Garcinia mangostana (Guttiferae)
Ee, G. C. L., Daud, S., Taufiq‐Yap, Y. H., et al. (2006) · Natural Product Research · doi:10.1080/14786410500463114 · Cited by 82
α-Mangostin Induces Ca2+-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells
Sato, A., Fujiwara, H., Oku, H., Ishiguro, K., & Ohizumi, Y. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.95.33 · Cited by 79
Xanthones from the heartwood of Garcinia mangostana
Nilar, L. (2002) · Phytochemistry · doi:10.1016/s0031-9422(02)00142-5 · Cited by 79
A xanthone from pericarps of Garcinia mangostana
Asai, F., Tosa, H., Tanaka, T., & Iinuma, M. (1995) · Phytochemistry · doi:10.1016/0031-9422(95)00042-6 · Cited by 67
Diet and healthy ageing 2100: Will we globalise local knowledge systems?
Heinrich, M., & Prieto, J. M. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.08.002 · Cited by 62
Self-citationChairungsrilerd, N., Furukawa, K., Ohta, T., Nozoe, S., & Ohizumi, Y. (1996) · Planta Medica · doi:10.1055/s-2006-957943 · Cited by 59
Efficacy of Slim339® in reducing body weight of overweight and obese human subjects
Toromanyan, E., Aslanyan, G., Amroyan, E., Gabrielyan, E. S., & Panossian, A. (2007) · Phytotherapy Research · doi:10.1002/ptr.2231 · Cited by 27
Cited by
García-Rivera, D., Delgado, R., Bougarne, N., Haegeman, G., & Vanden Berghe, W. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.02.011 · Cited by 142
Wittenauer, J., Falk, S., Schweiggert-Weisz, U., & Carle, R. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.094 · Cited by 90
Samprasit, W., Opanasopit, P., & Chamsai, B. (2021) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2021.1873370 · Cited by 50
Saptarini, N. M., & Hadisoebroto, G. (2020) · Rasayan Journal of Chemistry · doi:10.31788/rjc.2020.1325533 · Cited by 22
Metadata
- Authors
- Obolskiy, D., Pischel, I., Siriwatanametanon, N., & Heinrich, M.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2009-01-27
- Volume
- 23
- Issue
- 8
- Pages
- 1047-1065
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1995614441
- Cited by
- 366
- References
- 34
- FWCI
- 18.14
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
