Protective Effects of Fermented Citrus unshiu Peel Extract against Ultraviolet-A-induced Photoageing in Human Dermal Fibrobolasts
Abstract
The aqueous extracts of Citrus unshiu peel containing flavonoid glycosides was used as co-substrate with Schizophyllum commune mycelia producing β-glucosidase and its biological activities were studied. β-glucosidase-produced S. commune mycelia converted the glycosides (narirutin and hesperidin) into aglycones (naringenin and hesperetin). The photoprotective potential of fermented C. unshiu peel extract with S. commune (S-CPE) was tested in human dermal fibroblasts (HDFs) exposed to UVA. It was revealed that S-CPE had an inhibitory effect on human interstitial collagenase (matrix metalloproteinase, MMP-1) expression in UVA-irradiated HDFs. The treatment of UVA-irradiated HDFs with S-CPE resulted in a dose-dependent decrease in the expression level of MMP-1 mRNA. The UVA irradiation raised the proportion of senescence-associated β-galactosidase (SA-β-gal) positive cells in comparison with the normal control group. The treatment of UVA-irradiated HDFs with S-CPE was shown to decrease the level of SA-β-gal (by approximately 45% at an S-CPE concentration 0.1%, w/v) compared with the UVA-irradiated HDFs. It was found that S-CPE containing hesperetin has notable collagen biosynthetic activity for fibroblasts, indicating that S-CPE can be promising cosmetic ingredients.
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Fermented C. unshiu peel extract with S. commune had an inhibitory effect on human interstitial collagenase expression in human dermal fibroblasts exposed to UVA radiation.
“The photoprotective potential of fermented C. unshiu peel extract with S. commune was tested in human dermal fibroblasts exposed to UVA radiation, and it was revealed that it had an inhibitory effect on human interstitial collagenase expression.”
From Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review (2024) · cites this paper as [103]
Essential oil of Citrus unshiu peels has anti-inflammatory and antimicrobial properties.
“Moreover, the essential oil of Citrus unshiu peels has anti-inflammatory and antimicrobial properties [55,103].”
From Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review (2024) · cites this paper as [103]
Fermented Citrus unshiu peel with Schizophyllum commune QG143 has anti-aging and anti-photoaging properties.
“Citrus unshiu peel Schizophyllum commune QG143 Anti-aging, anti-photoaging [103]”
From Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review (2024) · cites this paper as [103]
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- Authors
- Bae, J. T., Ko, H. J., Kim, G. B., Pyo, H. B., & Lee, G. S.
- Affiliations
- R & D Center Hanbul Cosmetics Co. Chungbuk 369‐830 Republic of Korea
- Corresponding author
- Lee, Geun Soo
- ORCID
- Ko, Hyun Ju
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2012-03-15
- Volume
- 26
- Issue
- 12
- Pages
- 1851-1856
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1598451650
- Cited by
- 55
- References
- 25
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 16 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Knowledge Economy
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Bioactive Compounds in Plants
- Keywords
- Citrus unshiu peel, fermented plant extract, Schizophyllum commune, β-glucosidase, flavonoid glycosides, hesperetin, naringenin, MMP-1, collagenase inhibition, photoaging, UVA irradiation, human dermal fibroblasts, senescence-associated β-galactosidase, collagen synthesis, photoprotection, cosmetic ingredients
- MeSH terms
- beta-Galactosidase, Cells, Cultured, Citrus, Collagen, Disaccharides, Fermentation, Fibroblasts, Fruit, Hesperidin, Humans, Plant Extracts, Schizophyllum, Ultraviolet Rays, Skin Aging, Dermis, Matrix Metalloproteinase 1, Flavanones
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