Cited by 49Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsEssential Oils and Antimicrobial Activity

Lavender and Coriander Essential Oils and Their Main Component Linalool Exert a Protective Effect against Amyloid-β Neurotoxicity

Caputo, Lucia, Piccialli, Ilaria, Ciccone, Roselia, de Caprariis, Paolo, Massa, Antonio, De Feo, Vincenzo, Pannaccione, Anna·2021·Phytotherapy Research

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder leading to cognitive deficits and cognitive decline. Since no cure or preventing therapy is currently available to counteract AD, natural‐derived compounds are investigated to find new potential neuroprotective agents for its treatment. In the present study, we tested the neuroprotective effect of lavender and coriander essential oils (EOs) and their main active constituent linalool, against the neurotoxicity elicited by Aβ1‐42 oligomers, a key molecular factor in the neurodegeneration of AD. Importantly, our findings on neuronally differentiated PC12 cells exposed to Aβ1‐42 oligomers are in accordance with previous in vivo studies reporting the neuroprotective potential of lavender and coriander EOs and linalool. We found that lavender and coriander EOs at the concentration of 10 μg/mL as well as linalool at the same concentration were able to improve viability and to reduce nuclear morphological abnormalities in cells treated with Aβ1‐42 oligomers for 24 hours. Lavender and coriander EOs and linalool also showed to counteract the increase of intracellular reactive oxygen species production and the activation of the pro‐apoptotic enzyme caspase‐3 induced by Aβ1‐42 oligomers. Our findings provide further evidence that these EOs and their main constituent linalool could be natural agents of therapeutic interest against Aβ1‐42‐induced neurotoxicity.

Integrity signals

Registry

Crossref · 10.1002/ptr.6827

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Lavandula angustifolia and Coriandrum sativum essential oils containing linalool as major component display antioxidant and anti-apoptotic effects.

    “In agreement, Lavandula angustifolia and Coriandrum sativum essential oils containing linalool as major component have also displayed antioxidant and anti-apoptotic effects, hence confirming the beneficial potential of linalool in synergistic combination with other components (Caputo et al., 2021).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Caputo, L., Piccialli, I., Ciccone, R., de Caprariis, P., Massa, A., De Feo, V., & Pannaccione, A.
Affiliations
  • University of Salerno (IT)
  • University of Naples Federico II (IT)
  • Department of Pharmacy University of Salerno Salerno Italy
  • Department of Chemistry and Biology “A. Zambelli” University of Salerno Salerno Italy
Venue
Phytotherapy Research
Publisher
Wiley
Published
2020-08-12
Volume
35
Issue
1
Pages
486-493
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
OpenAlex
W3048670259
Cited by
49
References
42
Citations by year
2026: 3 · 2025: 9 · 2024: 5 · 2023: 14 · 2022: 13 · 2021: 5
FWCI
8.84
Type
journal article
Language
en
Open access
closed
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords
lavender essential oil, coriander essential oil, linalool, Alzheimer's disease, neuroprotection, neurotoxicity, PC12 cells, reactive oxygen species, caspase-3, apoptosis
MeSH terms
Acyclic Monoterpenes, Alzheimer Disease, Animals, Cognition Disorders, Oils, Volatile, Peptide Fragments, Plant Oils, Amyloid beta-Peptides, PC12 Cells, Reactive Oxygen Species, Neuroprotective Agents, Lavandula, Coriandrum, Rats, Cognitive Dysfunction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review