Lavender and Coriander Essential Oils and Their Main Component Linalool Exert a Protective Effect against Amyloid-β Neurotoxicity
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder leading to cognitive deficits and cognitive decline. Since no cure or preventing therapy is currently available to counteract AD, natural‐derived compounds are investigated to find new potential neuroprotective agents for its treatment. In the present study, we tested the neuroprotective effect of lavender and coriander essential oils (EOs) and their main active constituent linalool, against the neurotoxicity elicited by Aβ1‐42 oligomers, a key molecular factor in the neurodegeneration of AD. Importantly, our findings on neuronally differentiated PC12 cells exposed to Aβ1‐42 oligomers are in accordance with previous in vivo studies reporting the neuroprotective potential of lavender and coriander EOs and linalool. We found that lavender and coriander EOs at the concentration of 10 μg/mL as well as linalool at the same concentration were able to improve viability and to reduce nuclear morphological abnormalities in cells treated with Aβ1‐42 oligomers for 24 hours. Lavender and coriander EOs and linalool also showed to counteract the increase of intracellular reactive oxygen species production and the activation of the pro‐apoptotic enzyme caspase‐3 induced by Aβ1‐42 oligomers. Our findings provide further evidence that these EOs and their main constituent linalool could be natural agents of therapeutic interest against Aβ1‐42‐induced neurotoxicity.
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Lavandula angustifolia and Coriandrum sativum essential oils containing linalool as major component display antioxidant and anti-apoptotic effects.
“In agreement, Lavandula angustifolia and Coriandrum sativum essential oils containing linalool as major component have also displayed antioxidant and anti-apoptotic effects, hence confirming the beneficial potential of linalool in synergistic combination with other components (Caputo et al., 2021).”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Caputo et al., 2021
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RİFAMPİSİN KAYNAKLI BEYİN DOKUSU HASARINDA LİNALOOL’UN İYİLEŞTİRİCİ RÖLÜ
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- Authors
- Caputo, L., Piccialli, I., Ciccone, R., de Caprariis, P., Massa, A., De Feo, V., & Pannaccione, A.
- Affiliations
- University of Salerno (IT)
- University of Naples Federico II (IT)
- Department of Pharmacy University of Salerno Salerno Italy
- Department of Chemistry and Biology “A. Zambelli” University of Salerno Salerno Italy
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2020-08-12
- Volume
- 35
- Issue
- 1
- Pages
- 486-493
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W3048670259
- Cited by
- 49
- References
- 42
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 14 · 2022: 13 · 2021: 5
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- lavender essential oil, coriander essential oil, linalool, Alzheimer's disease, neuroprotection, neurotoxicity, PC12 cells, reactive oxygen species, caspase-3, apoptosis
- MeSH terms
- Acyclic Monoterpenes, Alzheimer Disease, Animals, Cognition Disorders, Oils, Volatile, Peptide Fragments, Plant Oils, Amyloid beta-Peptides, PC12 Cells, Reactive Oxygen Species, Neuroprotective Agents, Lavandula, Coriandrum, Rats, Cognitive Dysfunction
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