The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
A study of ion suppression effects in electrospray ionization from mobile phase additives and solid‐phase extracts
Abstract
Since the wide adoption of liquid chromatography/tandem mass spectrometry (LC/MS/MS), the ion suppression/enhancement phenomenon is the latest barrier to high‐throughput analysis. This consequence of a nonoptimized analytical method can lead to adverse effects during quantitation (i.e. poor accuracy and precision). Previous papers have reported that ion suppression is a direct result of endogenous material present in biological samples. However, in the case of a solid‐phase liquid chromatography/tandem mass spectrometry (SPE/LC/MS/MS) system, the measured result is the combination of several operating conditions and parameters. Little has been done to effectively monitor and/or choose optimized conditions for the complete sequence of extraction, clean up, separation and analysis. This paper describes a simple setup for quantification of ion suppression/enhancement. Several mobile phase additives, ion‐pairing agents and SPE extracts were measured and compared against a standard reference. The results demonstrated that a clean up of plasma extracts based on ion exchange leads to minimal ion suppression/enhancement for the compounds that were investigated. Copyright © 2003 John Wiley & Sons, Ltd.
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Cites
Matuszewski, B. K., Constanzer, M. L., & Chavez-Eng, C. M. (2003) · Analytical Chemistry · doi:10.1021/ac020361s · Cited by 5,335
Dole, M., Mack, L. L., Hines, R. L., Mobley, R. C., Ferguson, L. D., & Alice, M. B. (1968) · The Journal of Chemical Physics · doi:10.1063/1.1670391 · Cited by 1,613
Electrospray interface for liquid chromatographs and mass spectrometers
Whitehouse, C. M., Dreyer, R. N., Yamashita, M., & Fenn, J. B. (1985) · Analytical Chemistry · doi:10.1021/ac00280a023 · Cited by 1,512
Practical implications of some recent studies in electrospray ionization fundamentals
Cech, N. B., & Enke, C. G. (2001) · Mass Spectrometry Reviews · doi:10.1002/mas.10008 · Cited by 1,435
On the evaporation of small ions from charged droplets
Iribarne, J. V., & Thomson, B. A. (1976) · The Journal of Chemical Physics · doi:10.1063/1.432536 · Cited by 1,281
Mechanistic investigation of ionization suppression in electrospray ionization
King, R., Bonfiglio, R., Fernandez-Metzler, C., Miller-Stein, C., & Olah, T. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(00)00163-x · Cited by 1,086
Mei, H., Hsieh, Y., Nardo, C., Xu, X., Wang, S., Ng, K., & Korfmacher, W. A. (2003) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.876 · Cited by 350
Protonation in electrospray mass spectrometry: Wrong-way-round or right-way-round?
Zhou, S., & Cook, K. D. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(00)00174-4 · Cited by 140
Avery, M. J. (2002) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.895 · Cited by 115
van Hout, M. W. J., Niederländer, H. A. G., de Zeeuw, R. A., & de Jong, G. J. (2002) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.908 · Cited by 70
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Farré, M. L., Pérez, S., Kantiani, L., & Barceló, D. (2008) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.09.010 · Cited by 1,009
Mullin, L., Katz, D. R., Riddell, N., Plumb, R., Burgess, J. A., Yeung, L. W. Y., & Jogsten, I. E. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.05.015 · Cited by 91
Zhang, D., Rios, D. R., Tam, V. H., & Chow, D. S.-L. (2014) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2014.07.001 · Cited by 29
Metadata
- Authors
- Mallet, C. R., Lu, Z., & Mazzeo, J. R.
- Venue
- Rapid Communications in Mass Spectrometry
- Publisher
- Wiley
- Published
- 2003-12-04
- Volume
- 18
- Issue
- 1
- Pages
- 49-58
- ISSN
- 0951-4198 (ISSN-L)
- 1097-0231
- OpenAlex
- W2144957010
- Cited by
- 441
- References
- 11
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mallet, C. R., Lu, Z., & Mazzeo, J. R. (2004). A study of ion suppression effects in electrospray ionization from mobile phase additives and solid‐phase extracts. Rapid Communications in Mass Spectrometry. https://doi.org/10.1002/rcm.1276
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