The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging
Open accessAbstract
Epidermal growth factor receptor (EGFR) targeted nanoparticle are developed by conjugating a single‐chain anti‐EGFR antibody (ScFvEGFR) to surface functionalized quantum dots (QDs) or magnetic iron oxide (IO) nanoparticles. The results show that ScFvEGFR can be successfully conjugated to the nanoparticles, resulting in compact ScFvEGFR nanoparticles that specifically bind to and are internalized by EGFR‐expressing cancer cells, thereby producing a fluorescent signal or magnetic resonance imaging (MRI) contrast. In vivo tumor targeting and uptake of the nanoparticles in human cancer cells is demonstrated after systemic delivery of ScFvEGFR‐QDs or ScFvEGFR‐IO nanoparticles into an orthotopic pancreatic cancer model. Therefore, ScFvEGFR nanoparticles have potential to be used as a molecular‐targeted in vivo tumor imaging agent. Efficient internalization of ScFvEGFR nanoparticles into tumor cells after systemic delivery suggests that the EGFR‐targeted nanoparticles can also be used for the targeted delivery of therapeutic agents.
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Cited by
Targeting nanoparticles to cancer
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Self-citationEngineering of inorganic nanoparticles as magnetic resonance imaging contrast agents
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Energy Transfer from Quantum Dots to Metal–Organic Frameworks for Enhanced Light Harvesting
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Metadata
- Authors
- Yang, L., Mao, H., Wang, Y. A., Cao, Z., Peng, X., Wang, X., Duan, H., Ni, C., Yuan, Q., Adams, G., Smith, M. Q., Wood, W. C., Gao, X., & Nie, S.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2009-01-19
- Volume
- 5
- Issue
- 2
- Pages
- 235-243
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2011690386
- Cited by
- 356
- References
- 37
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, L., Mao, H., Wang, Y. A., Cao, Z., Peng, X., Wang, X., Duan, H., Ni, C., Yuan, Q., Adams, G., Smith, M. Q., Wood, W. C., Gao, X., & Nie, S. (2009). Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging. Small. https://doi.org/10.1002/smll.200800714
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