The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Electrospray Encapsulation of Hydrophilic and Hydrophobic Drugs in Poly(L‐lactic acid) Nanoparticles
Abstract
An electrospray method is developed for preparation of beclomethasone‐dipropionate‐ and salbutamol‐sulfate‐loaded biodegradable poly(L‐lactic acid) nanoparticles. Different set‐up parameters for electrospraying are examined on particle size, and preparation conditions are optimized for producing spherical‐drug‐loaded nanoscale particles by controllable processing parameters. Polylactide (PLA)–drug nanoparticles with average diameters of around 200 nm are achieved in a stable cone‐jet mode with a flow rate of 4 µL min−1, polymer concentration of 1%, and ammonium hydroxide content of 0.05%. Morphology and size of the drug–polymer nanoparticles are analyzed by scanning electron microscopy and transmission electron microscopy. Changes in the crystallinity of the PLA polymer and the model drugs are detected by X‐ray powder diffraction, and the absence of molecular interactions are confirmed by thermal analyses. The results indicate clearly that electrospraying is a potential method for producing polymeric nanoparticles and for encapsulating both hydrophilic and hydrophobic drugs efficiently into the nanoparticles.
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Citations
Cites
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549
Cited by
Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering
Narayanan, G., Vernekar, V. N., Kuyinu, E. L., & Laurencin, C. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.015 · Cited by 484
Electrospraying of polymers with therapeutic molecules: State of the art
Bock, N., Dargaville, T. R., & Woodruff, M. A. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.03.002 · Cited by 440
Xie, J., Jiang, J., Davoodi, P., Srinivasan, M. P., & Wang, C.-H. (2015) · Chemical Engineering Science · doi:10.1016/j.ces.2014.08.061 · Cited by 317
Drug release from core-shell PVA/silk fibroin nanoparticles fabricated by one-step electrospraying
Cao, Y., Liu, F., Chen, Y., Yu, T., Lou, D., Guo, Y., Li, P., Wang, Z., & Ran, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-12351-1 · Cited by 104
Aliphatic Polyester-Based Biodegradable Microbeads for Sustainable Cosmetics
Nam, H. C., & Park, W. H. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00017 · Cited by 29
Metadata
- Authors
- Valo, H., Peltonen, L., Vehviläinen, S., Karjalainen, M., Kostiainen, R., Laaksonen, T., & Hirvonen, J.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2009-07-31
- Volume
- 5
- Issue
- 15
- Pages
- 1791-1798
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2010229174
- Cited by
- 158
- References
- 1
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Valo, H., Peltonen, L., Vehviläinen, S., Karjalainen, M., Kostiainen, R., Laaksonen, T., & Hirvonen, J. (2009). Electrospray Encapsulation of Hydrophilic and Hydrophobic Drugs in Poly(L‐lactic acid) Nanoparticles. Small. https://doi.org/10.1002/smll.200801907
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