The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Biosafety and Bioapplication of Nanomaterials by Designing Protein–Nanoparticle Interactions
Abstract
The protein–nanoparticle (NP) interface is a current frontier of multiple disciplines, full of challenges and opportunities. The unique behaviors of nanomaterials (NMs) bring many exciting applications, and also raise safety concerns. Beyond bioapplications, various NMs could also enter human bodies from the environment. When entering human bodies, NPs interact with various biomolecules, especially proteins, forming a protein corona. This protein–NP complex is what the biosystems 'see' and 'respond to'. Therefore, understanding how NPs interact with proteins is crucial for both bioapplications and the biosafety of NMs. In this review, the current understanding of protein–NP interactions is summarized, including the theoretical background, experimental results, and computational progresses. Guidelines for improving bioapplication performance and reducing the potential biosafety hazard of NMs by designing the protein–NP interactions are discussed, along with future directions and challenges in this exciting field.
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Cites
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Cited by
The potential of protein–nanomaterial interaction for advanced drug delivery
Peng, Q., & Mu, H. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.041 · Cited by 134
Macromolecular Coronas and Their Importance in Nanotoxicology and Nanoecotoxicology
Lynch, I., Dawson, K. A., Lead, J. R., & Valsami-Jones, E. (2014) · Frontiers of Nanoscience · doi:10.1016/b978-0-08-099408-6.00004-9 · Cited by 61
Metadata
- Authors
- Yang, S., Liu, Y., Wang, Y., & Cao, A.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2013-01-23
- Volume
- 9
- Issue
- 9-10
- Pages
- 1635-1653
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W1975329691
- Cited by
- 296
- References
- 133
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- closed
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