The potential of protein–nanomaterial interaction for advanced drug delivery

Peng, Qiang; Mu, Huiling

doi:10.1016/j.jconrel.2016.01.041

Cited by 134Nanoparticle-Based Drug DeliveryProtein Interaction Studies and Fluorescence AnalysisAdvanced Drug Delivery Systems

The potential of protein–nanomaterial interaction for advanced drug delivery

Peng, Qiang, Mu, Huiling·2016·Journal of Controlled Release

DOI 10.1016/j.jconrel.2016.01.041

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Abstract

Nanomaterials, like nanoparticles, micelles, nano-sheets, nanotubes and quantum dots, have great potentials in biomedical fields. However, their delivery is highly limited by the formation of protein corona upon interaction with endogenous proteins. This new identity, instead of nanomaterial itself, would be the real substance the organs and cells firstly encounter. Consequently, the behavior of nanomaterials in vivo is uncontrollable and some undesired effects may occur, like rapid clearance from blood stream; risk of capillary blockage; loss of targeting capacity; and potential toxicity. Therefore, protein-nanomaterial interaction is a great challenge for nanomaterial systems and should be inhibited. However, this interaction can also be used to functionalize nanomaterials by forming a selected protein corona. Unlike other decoration using exogenous molecules, nanomaterials functionalized by selected protein corona using endogenous proteins would have greater promise for clinical use. In this review, we aim to provide a comprehensive understanding of protein-nanomaterial interaction. Importantly, a discussion about how to use such interaction is launched and some possible applications of such interaction for advanced drug delivery are presented.

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Serum proteins bind on the surface of synthetic nanoparticle carriers immediately after entering the bloodstream, forming protein coronas.
“It was reported that serum proteins bind on the surface of synthetic nanoparticle (NP) carriers immediately after entering the bloodstream, forming so-called protein coronas [34,35].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [34]

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Authors: Peng, Q., & Mu, H.
Affiliations: University of Copenhagen (DK)
Corresponding author: Peng, Qiang
ORCID: Peng, Qiang
Mu, Huiling
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2016-03
Volume: 225
Pages: 121-132
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2016.01.041
OpenAlex: W2288574037
Cited by: 134
References: 126
Citations by year: 2026: 6 · 2025: 10 · 2024: 12 · 2023: 6 · 2022: 14 · 2021: 14 · 2020: 20 · 2019: 18 · 2018: 15 · 2017: 12 · 2016: 7
FWCI: 0.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: National Natural Science Foundation of China (81402860)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: nanoparticle-protein interactions, protein corona, drug delivery, nanoparticles, micelles, quantum dots, nanotubes, nanosheets, nanomaterial functionalization, endogenous proteins, nanoparticle clearance, targeting, toxicity
MeSH terms: Adsorption, Proteins, Drug Delivery Systems, Nanostructures

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The potential of protein–nanomaterial interaction for advanced drug delivery

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