Top-down synthesis of multifunctional iron oxide nanoparticles for macrophage labelling and manipulation
Open accessAbstract
Multifunctional iron oxide (FeOx) magnetic nanoparticles (MNPs) are promising items for biomedical applications. They are studied as theranostic agents for cancer treatment, selective probes for bioanalytical assays, controllable carriers for drug delivery and biocompatible tools for cell sorting or tissue repair. Here we report a new method for the synthesis in water of FeOx–MNPsvia a top-down physical technique consisting in Laser Ablation Synthesis in Solution (LASiS). LASiS is a green method that does not require chemicals or stabilizers, because nanoparticles are directly obtained in water as a stable colloidal system. A gamut of characterization techniques was used for investigating the structure of FeOx–MNPs that have a polycrystalline structure prevalently composed of magnetite (ca. 75%) and hematite (ca. 22%). The FeOx–MNPs exhibit very good magnetic properties if compared to what is usually reported for iron oxide nanoparticles, with saturation magnetization close to the bulk value (ca. 80 emu g−1) and typical signatures of the coexistence of ferrimagnetic and antiferromagnetic phases in the same particle. The functionalization of FeOx–MNPs after the synthesis was possible with a variety of ligands. In particular, we succeeded in the functionalization of FeOx–MNPs with carboxylated phosphonates, fluorescent alkylamines, fluorescent isothiocyanates and bovine serum albumin. Our FeOx–MNPs showed excellent biocompatibility. Multifunctional FeOx–MNPs were exploited for macrophage cell labelling with fluorescent probes as well as for cell sorting and manipulation by external magnetic fields.
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Amendola et al. found that PLA of Fe in water yielded a polycrystalline structure of FeOx NPs, which exhibit magnetic properties and can have biomedical applications.
“Amendola et al. [145] examined PLA of Fe in water that yielded a polycrystalline structure of FeOx NPs, which exhibit magnetic properties and can have biomedical applications [146,147].”
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MEMBRANE IMMOBILIZED REACTIVE Fe/Pd NANOPARTICLES: MODELING AND TCE DEGRADATION RESULTS
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- Authors
- Amendola, V., Meneghetti, M., Granozzi, G., Agnoli, S., Polizzi, S., Riello, P., Boscaini, A., Anselmi, C., Fracasso, G., Colombatti, M., Innocenti, C., Gatteschi, D., & Sangregorio, C.
- Affiliations
- University of Padua (IT)
- Ca' Foscari University of Venice (IT)
- University of Verona (IT)
- National Interuniversity Consortium of Materials Science and Technology (IT)
- Institute of Molecular Science and Technologies (IT)
- Corresponding author
- Amendola, Vincenzo
- ORCID
- Venue
- Journal of Materials Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 21
- Issue
- 11
- Pages
- 3803
- ISSN
- 0959-9428 (ISSN-L)
- 1364-5501
- OpenAlex
- W2106106065
- Cited by
- 99
- References
- 63
- Citations by year
- 2025: 7 · 2024: 9 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 13 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 8 · 2014: 4 · 2013: 5 · 2012: 6
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Journal of Materials Chemistry (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- ARCA (Università Ca' Foscari Venezia) (submittedVersion, other-oa)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Laser-Ablation Synthesis of Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
- Keywords
- iron oxide nanoparticles, top-down synthesis, laser ablation in liquid, magnetite, hematite, magnetic nanoparticles, nanoparticle functionalization, bovine serum albumin, biocompatibility, magnetic cell separation, magnetic cell manipulation, theranostic agents, green synthesis
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