Cited by 99Laser-Ablation Synthesis of NanoparticlesCharacterization and Applications of Magnetic NanoparticlesMagnetic Properties and Synthesis of Ferrites

Top-down synthesis of multifunctional iron oxide nanoparticles for macrophage labelling and manipulation

Open access
Amendola, Vincenzo, Meneghetti, Moreno, Granozzi, Gaetano, Agnoli, Stefano, Polizzi, Stefano, Riello, Pietro, Boscaini, Anita, Anselmi, Cristina +5 more·2011·Journal of Materials Chemistry

Abstract

Multifunctional iron oxide (FeOx) magnetic nanoparticles (MNPs) are promising items for biomedical applications. They are studied as theranostic agents for cancer treatment, selective probes for bioanalytical assays, controllable carriers for drug delivery and biocompatible tools for cell sorting or tissue repair. Here we report a new method for the synthesis in water of FeOx–MNPsvia a top-down physical technique consisting in Laser Ablation Synthesis in Solution (LASiS). LASiS is a green method that does not require chemicals or stabilizers, because nanoparticles are directly obtained in water as a stable colloidal system. A gamut of characterization techniques was used for investigating the structure of FeOx–MNPs that have a polycrystalline structure prevalently composed of magnetite (ca. 75%) and hematite (ca. 22%). The FeOx–MNPs exhibit very good magnetic properties if compared to what is usually reported for iron oxide nanoparticles, with saturation magnetization close to the bulk value (ca. 80 emu g−1) and typical signatures of the coexistence of ferrimagnetic and antiferromagnetic phases in the same particle. The functionalization of FeOx–MNPs after the synthesis was possible with a variety of ligands. In particular, we succeeded in the functionalization of FeOx–MNPs with carboxylated phosphonates, fluorescent alkylamines, fluorescent isothiocyanates and bovine serum albumin. Our FeOx–MNPs showed excellent biocompatibility. Multifunctional FeOx–MNPs were exploited for macrophage cell labelling with fluorescent probes as well as for cell sorting and manipulation by external magnetic fields.

Integrity signals

Registry

Crossref · 10.1039/c0jm03863f

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Amendola, V., Meneghetti, M., Granozzi, G., Agnoli, S., Polizzi, S., Riello, P., Boscaini, A., Anselmi, C., Fracasso, G., Colombatti, M., Innocenti, C., Gatteschi, D., & Sangregorio, C.
Affiliations
  • University of Padua (IT)
  • Ca' Foscari University of Venice (IT)
  • University of Verona (IT)
  • National Interuniversity Consortium of Materials Science and Technology (IT)
  • Institute of Molecular Science and Technologies (IT)
Corresponding author
Amendola, Vincenzo
Venue
Journal of Materials Chemistry
Published
2011
Volume
21
Issue
11
Pages
3803
ISSN
  • 0959-9428 (ISSN-L)
  • 1364-5501
OpenAlex
W2106106065
Cited by
99
References
63
Citations by year
2025: 7 · 2024: 9 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 13 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 8 · 2014: 4 · 2013: 5 · 2012: 6
FWCI
3.60
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Journal of Materials Chemistry (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • ARCA (Università Ca' Foscari Venezia) (submittedVersion, other-oa)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Laser-Ablation Synthesis of Nanoparticles
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
Keywords
iron oxide nanoparticles, top-down synthesis, laser ablation in liquid, magnetite, hematite, magnetic nanoparticles, nanoparticle functionalization, bovine serum albumin, biocompatibility, magnetic cell separation, magnetic cell manipulation, theranostic agents, green synthesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review