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Mesenchymal Stem Cells Attenuate Renal Fibrosis Through Immune Modulation and Remodeling Properties in a Rat Remnant Kidney Model
Open accessAbstract
Mesenchymal stem cells (MSCs) have regenerative properties in acute kidney injury, but their role in chronic kidney diseases is still unknown. More specifically, it is not known whether MSCs halt fibrosis. The purpose of this work was to investigate the role of MSCs in fibrogenesis using a model of chronic renal failure. MSCs were obtained from the tibias and femurs of male Wistar-EPM rats. Female Wistar rats were subjected to the remnant model, and 2|×|105 MSCs were intravenously administrated to each rat every other week for 8 weeks or only once and followed for 12 weeks. SRY gene expression was observed in female rats treated with male MSCs, and immune localization of CD73+CD90+ cells at 8 weeks was also assessed. Serum and urine analyses showed an amelioration of functional parameters in MSC-treated animals at 8 weeks, but not at 12 weeks. Masson's trichrome and Sirius red staining demonstrated reduced levels of fibrosis in MSC-treated animals. These results were corroborated by reduced vimentin, type I collagen, transforming growth factor β, fibroblast specific protein 1 (FSP-1), monocyte chemoattractant protein 1, and Smad3 mRNA expression and α smooth muscle actin and FSP-1 protein expression. Renal interleukin (IL)-6 and tumor necrosis factor α mRNA expression levels were significantly decreased after MSC treatment, whereas IL-4 and IL-10 expression levels were increased. All serum cytokine expression levels were decreased in MSC-treated animals. Taken together, these results suggested that MSC therapy can indeed modulate the inflammatory response that follows the initial phase of a chronic renal injury. The immunosuppressive and remodeling properties of MSCs may be involved in the decreased fibrosis in the kidney. Disclosure of potential conflicts of interest is found at the end of this article.
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Citations
Cites
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Mesenchymal stem cells in health and disease
Uccelli, A., Moretta, L., & Pistoia, V. (2008) · Nature Reviews Immunology · doi:10.1038/nri2395 · Cited by 3,746
Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., Grisanti, S., & Gianni, A. M. (2002) · Blood · doi:10.1182/blood.v99.10.3838 · Cited by 3,226
Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation
Hostetter, T. H., Olson, J. L., Rennke, H. G., Venkatachalam, M. A., & Brenner, B. M. (1981) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1981.241.1.f85 · Cited by 1,680
Pathophysiology of Progressive Nephropathies
Remuzzi, G., & Bertani, T. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811123392007 · Cited by 1,269
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
Higgins, D. F., Kimura, K., Bernhardt, W. M., Shrimanker, N., Akai, Y., Hohenstein, B., Saito, Y., Johnson, R. S., Kretzler, M., Cohen, C. D., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30487 · Cited by 976
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery
Hofstetter, C. P., Schwarz, E. J., Hess, D., Widenfalk, J., El Manira, A., Prockop, D. J., & Olson, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042678299 · Cited by 967
Perspective Article: Tissue repair, contraction, and the myofibroblast
Desmoulière, A., Chaponnier, C., & Gabbiani, G. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130102.x · Cited by 892
Lin, S.-L., Kisseleva, T., Brenner, D. A., & Duffield, J. S. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.080433 · Cited by 845
Immunomodulation by mesenchymal stem cells and clinical experience
Le Blanc, K., & Ringdén, O. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01844.x · Cited by 720
Tögel, F., Weiss, K., Yang, Y., Hu, Z., Zhang, P., & Westenfelder, C. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00339.2006 · Cited by 641
Molecular basis of renal fibrosis
Eddy, A. A. (2000) · Pediatric Nephrology · doi:10.1007/s004670000461 · Cited by 637
Fibroblast Differentiation in Wound Healing and Fibrosis
Darby, I. A., & Hewitson, T. D. (2007) · International Review of Cytology · doi:10.1016/s0074-7696(07)57004-x · Cited by 600
Duffield, J. S., Park, K. M., Hsiao, L.-L., Kelley, V. R., Scadden, D. T., Ichimura, T., & Bonventre, J. V. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22593 · Cited by 571
Pathways to nephron loss starting from glomerular diseases—Insights from animal models
Kriz, W., & Lehir, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.67097.x · Cited by 468
A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats.
Shimamura, T., & Morrison, A. B. (1975) · PubMed · Cited by 449
Mesenchymal stem cells: the fibroblasts' new clothes?
Haniffa, M. A., Collin, M. P., Buckley, C. D., & Dazzi, F. (2009) · Haematologica · doi:10.3324/haematol.13699 · Cited by 345
Mesenchymal Stem Cells in Acute Kidney Injury
Humphreys, B. D., & Bonventre, J. V. (2008) · Annual Review of Medicine · doi:10.1146/annurev.med.59.061506.154239 · Cited by 331
Stem Cells and Cell Therapies in Lung Biology and Lung Diseases
Weiss, D. J., Kolls, J. K., Ortiz, L. A., Panoskaltsis-Mortari, A., & Prockop, D. J. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200804-037dw · Cited by 309
Ninichuk, V., Gross, O., Segerer, S., Hoffmann, R., Radomska, E., Buchstaller, A., Huss, R., Akis, N., Schlöndorff, D., & Anders, H.-J. (2006) · Kidney International · doi:10.1038/sj.ki.5001521 · Cited by 283
Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats
Kliem, V., Johnson, R. J., Alpers, C. E., Yoshimura, A., Couser, W. G., Koch, K. M., & Floege, J. (1996) · Kidney International · doi:10.1038/ki.1996.95 · Cited by 281
Grimm, P. C., Nickerson, P., Jeffery, J., Savani, R. C., Gough, J., McKenna, R. M., Stern, E., & Rush, D. N. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107123450203 · Cited by 269
Mechanisms of progression of chronic kidney disease
Fogo, A. B. (2007) · Pediatric Nephrology · doi:10.1007/s00467-007-0524-0 · Cited by 263
Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats
Romero, F., Rodríguez-Iturbe, B., Parra, G., González, L., Herrera-Acosta, J., & Tapia, E. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.055003945.x · Cited by 206
Re-expression of the developmental gene Pax-2 during experimental acute tubular necrosis in mice1
Imgrund, M., Gröne, E., Gröne, H.-J., Kretzler, M., Holzman, L., Schlöndorff, D., & Rothenpieler, U. W. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00663.x · Cited by 202
Duffield, J. S., & Bonventre, J. V. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00629.x · Cited by 193
Mycophenolate mofetil attenuates renal injury in the rat remnant kidney
Fujihara, C. K., Malheiros, D. M. A. C., Zatz, R., & Noronha, I. D. L. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00138.x · Cited by 178
Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins
Villanueva, S., Céspedes, C., & Vio, C. P. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00384.2005 · Cited by 168
The Role of Mesenchymal Stem Cells in the Functional Improvement of Chronic Renal Failure
Choi, S., Park, M., Kim, J., Hwang, S., Park, S., & Lee, Y. (2009) · Stem Cells and Development · doi:10.1089/scd.2008.0097 · Cited by 158
EMT and proteinuria as progression factors
Strutz, F. M. (2008) · Kidney International · doi:10.1038/ki.2008.425 · Cited by 129
Mesenchymal Stem Cells Ameliorate Tissue Damages Triggered by Renal Ischemia and Reperfusion Injury
Semedo, P., Wang, P., Andreucci, T. H., Cenedeze, M. A., Teixeira, V. P. A., dos Reis, M. A., Pacheco‐Silva, Á., & Câmara, N. O. S. (2007) · Transplantation Proceedings · doi:10.1016/j.transproceed.2007.01.036 · Cited by 127
Self-citationEarly modulation of inflammation by mesenchymal stem cell after acute kidney injury
Semedo, P., Palasio, C. G., Donizetti-Oliveira, C., Feitoza, C. Q., Gonçalves, G. M., Cenedeze, M. A., Wang, P. H. M., Teixeira, V. P. A., dos Reis, M. A., Pacheco‐Silva, Á., et al. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2008.12.008 · Cited by 126
Self-citationLi, L., Zhang, Y., Li, Y., Yu, B., Xu, Y., Zhao, S.-D., & Guan, Z. (2008) · Transplant International · doi:10.1111/j.1432-2277.2008.00742.x · Cited by 122
Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney
Taal, M. W., Zandi‐Nejad, K., Weening, B., Shahsafaei, A., Kato, S., Lee, K., Ziai, F., Jiang, T., Brenner, B. M., & Mackenzie, H. S. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00327.x · Cited by 121
Mesenchymal Stem Cell Transplantation for Neurodegenerative Diseases
Torrente, Y., & Polli, E. E. (2008) · Cell Transplantation · doi:10.3727/096368908787236576 · Cited by 112
The inflammatory component in progressive renal disease—are interventions possible?
Noronha, I. L., Fujihara, C. K., & Zatz, R. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/17.3.363 · Cited by 105
Inumaru, J., Nagano, O., Takahashi, E., Ishimoto, T., Nakamura, S., Suzuki, Y., Niwa, S., Umezawa, K., Tanihara, H., & Saya, H. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01303.x · Cited by 96
Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction
Câmara, N. O. S., & Soares, M. P. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.019 · Cited by 93
Heme oxygenase and renal disease
Jarmi, T., & Agarwal, A. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0011-z · Cited by 93
Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy
Gao, X., Mae, H., Ayabe, N., Takai, T., Oshima, K., Hattori, M., 植木, 孝., Fujimoto, J., & Tanizawa, T. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00579.x · Cited by 81
Regression of Advanced Diabetic Nephropathy by Hepatocyte Growth Factor Gene Therapy in Rats
Cruzado, J. M., Lloberas, N., Torrás, J., Riera, M., Fillat, C., Herrero, I., Aran, J. M., Alperovich, G., Vidal, A., & Grinyo, J. M. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1119 · Cited by 76
Takahashi, T., Shimizu, H., Morimatsu, H., Maeshima, K., Inoue, K., Akagi, R., Matsumi, M., Katayama, H., & Morita, K. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.08-210-ho · Cited by 74
Mesenchymal Stem Cells for the Treatment of Heart Failure
Ohnishi, S., Ohgushi, H., Kitamura, S., & Nagaya, N. (2007) · International Journal of Hematology · doi:10.1532/ijh97.07041 · Cited by 71
Fleck, C., Appenroth, D., Jonas, P., Koch, M., Kundt, G., Nizze, H., & Stein, G. (2005) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2005.09.005 · Cited by 69
Mechanisms underlying renoprotection during renin-angiotensin system blockade
Taal, M. W., Chertow, G. M., Rennke, H. G., Gurnani, A., Jiang, T., Shahsafaei, A., Troy, J. L., Brenner, B. M., & Mackenzie, H. S. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.2.f343 · Cited by 60
Lineage-Negative Bone Marrow Cells Protect Against Chronic Renal Failure
Alexandre, C. S., Volpini, R. A., Shimizu, M. H. M., Sanches, T. R., Semedo, P., di Jura, V. L., Câmara, N. O. S., Seguro, A. C., & Andrade, L. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0496 · Cited by 51
Self-citationEffect of Whole Bone Marrow Cell Infusion in the Progression of Experimental Chronic Renal Failure
Caldas, H. C., Fernandes, I. M. M., Gerbi, F., de Souza, A. C. C. P., Baptista, M. A. S. F., Ramalho, H. J., Kawasaki‐Oyama, R. S., Goloni‐Bertollo, E. M., Pavarino, É. C., Braile, D. M., et al. (2008) · Transplantation Proceedings · doi:10.1016/j.transproceed.2008.03.009 · Cited by 50
Focal glomerulosclerosis in the remnant kidney model--an inflammatory disease mediated by cytokines
Schiller, B. M., & Moran, J. (1997) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/12.3.430 · Cited by 50
The bone marrow leaves its scar: new concepts in pulmonary fibrosis
Dunsmore, S. E., & Shapiro, S. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420782 · Cited by 43
Participation of bone marrow cells in biliary fibrosis after bile duct ligation
Asawa, S., Saito, T., Satoh, A., Ohtake, K., Tsuchiya, T., Okada, H., Neilson, E. G., & Gotoh, M. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04708.x · Cited by 31
Kagawa, T., Takemura, G., Kosai, K.-I., Murata, I., Ohno, T., Takahashi, T., Esaki, M., Maruyama, R., Fujiwara, T., Ohashi, H., et al. (2005) · Nephron Physiology · doi:10.1159/000090071 · Cited by 29
The Role of Bone Marrow-Derived Cells in Fibrosis
Lin, W., Brittan, M., & Alison, M. R. (2008) · Cells Tissues Organs · doi:10.1159/000113530 · Cited by 24
The Third World Kidney Day: Looking Back and Thinking Forward
Shah, S. V., & Feehally, J. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.12.007 · Cited by 8
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Shi, Y., Wang, Y., Li, Q., Liu, K., Hou, J., Shao, C., & Wang, Y. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0023-5 · Cited by 1,223
Mechanisms of Tubulointerstitial Fibrosis
Zeisberg, M., & Neilson, E. G. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080793 · Cited by 868
Eggenhofer, E., Benseler, V., Kroemer, A., Popp, F. C., Geissler, E. K., Schlitt, H. J., Baan, C. C., Dahlke, M. H., & Hoogduijn, M. J. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00297 · Cited by 804
Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
Mirotsou, M., Jayawardena, T. M., Schmeckpeper, J., Gnecchi, M., & Dzau, V. J. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.08.005 · Cited by 486
Mesenchymal stem cell therapy for liver fibrosis
Eom, Y. W., Shim, K. Y., & Baik, S. K. (2015) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2015.30.5.580 · Cited by 226
Metadata
- Authors
- Semedo, P., Correa-Costa, M., Antonio Cenedeze, M., Maria Avancini Costa Malheiros, D., Antonia dos Reis, M., Shimizu, M. H., Seguro, A. C., Pacheco-Silva, A., & Saraiva Ĉamara, N. O.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-09-11
- Volume
- 27
- Issue
- 12
- Pages
- 3063-3073
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2083056880
- Cited by
- 295
- References
- 53
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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