The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Concise Review: MSC Adhesion Cascade—Insights into Homing and Transendothelial Migration
Open accessAbstract
Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in regenerative medicine. To fully exert their potential, efficient homing and migration toward lesion sites play an important role. Local transplantation deposits MSC in spatial proximity to the lesion, but often requires invasive procedures. Systemic administration routes are favored, but require the targeted extravasation of the circulating MSC at the site of injury. Transplanted MSC can indeed leave the blood flow and transmigrate through the endothelial barrier, and reach the lesion site. However, the underlying processes are not completely dissolved yet. Recent in vitro and in vivo research identified some key molecules scattered light on the extravasation mechanism. This review provides a detailed overview over the current knowledge of MSC transendothelial migration. We use the leukocyte extravasation process as a role model to build a comprehensive concept of MSC egress mechanisms from the blood stream and identified relevant similarities as well as important differences between the extravasation mechanisms.
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Biological functions of mesenchymal stem cells and clinical implications
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“Moreover, MSC ability to adhere to the endothelium is essential to ‘MSC homing’, a crucial multistep process that allows therapeutic cells to reach their target area [39, 40].”
BackgroundCyasterone accelerates fracture healing by promoting MSCs migration and osteogenesis
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Metadata
- Authors
- Nitzsche, F., Müller, C., Lukomska, B., Jolkkonen, J., Deten, A., & Boltze, J.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-04-03
- Volume
- 35
- Issue
- 6
- Pages
- 1446-1460
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2619544969
- Cited by
- 382
- References
- 144
- FWCI
- 16.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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