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Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors

Poglio, Sandrine, De Toni-Costes, Fabienne, Arnaud, Emmanuelle, Laharrague, Patrick, Espinosa, Eric, Casteilla, Louis, Cousin, Béatrice·2010·Stem Cells
DOI 10.1002/stem.523
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Abstract

White adipose tissue (WAT) is a heterogeneous tissue, found in various locations throughout the body, containing mature adipocytes and the stroma-vascular fraction (SVF). The SVF includes a large proportion of immune hematopoietic cells, among which, mast cells that contribute to diet-induced obesity. In this study, we asked whether mast cells present in mice adipose tissue could derive from hematopoietic stem/progenitor cells (HSPC) identified in the tissue. We therefore performed both in vitro and in vivo experiments dedicated to monitoring the progeny of WAT-derived HSPC. The entire study was conducted in parallel with bone marrow-derived cells, considered the gold standard for hematopoietic-lineage studies. Here, we demonstrate that adipose-derived HSPC contain a precursor-cell population committed to the mast cell lineage, and able to efficiently home to peripheral organs such as intestine and skin, where it acquires properties of functional tissue mast cells. Additionally, WAT contains a significant mast cell progenitor population, suggesting that the entire mast cell lineage process take place in WAT. Considering the quantitative importance of WAT in the adult organism and the increasing roles recently assigned to mast cells in physiopathology, WAT may represent an important source of mast cells in physiological and pathological situations.

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Research works printed but not linked: 30

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Metadata

Authors
Poglio, S., De Toni-Costes, F., Arnaud, E., Laharrague, P., Espinosa, E., Casteilla, L., & Cousin, B.
Affiliations
  • CNRS, UMR 5241 Métabolisme, Plasticité et Mitochondrie andToulouse, France
  • Institut National de la Santé et de la Recherche Médicale (INSERM), U563 andCentre de Physiopathologie de Toulouse-Purpan, Toulouse, France
Venue
Stem Cells
Publisher
Oxford University Press (OUP)
Published
2010-11-01
Volume
28
Issue
11
Pages
2065-2072
ISSN
  • 1066-5099
  • 1549-4918
DOI
10.1002/stem.523
Cited by
111
References
5
Language
en
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Funders
  • ANR (≪Floradip≫ANR-08-BLAN-0324-04)
  • French “Ministère de la Recherche et de la Technologie.”

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