The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Concise Review: Adipose-Derived Stromal Cells for Skeletal Regenerative Medicine
Open accessAbstract
As the average age of the population grows, the incidence of osteoporosis and skeletal diseases continues to rise. Current treatment options for skeletal repair include immobilization, rigid fixation, alloplastic materials, and bone grafts, all which have significant limitations, especially in the elderly. Adipose-derived stromal cells (ASCs) represent a readily available abundant supply of mesenchymal stem cells, which demonstrate the ability to undergo osteogenesis in vitro and in vivo, making ASCs a promising source of skeletal progenitor cells. Current protocols allow for the harvest of over one million cells from only 15 ml of lipoaspirate. Despite the clinical use of ASCs to treat systemic inflammatory diseases, no large human clinical trials exist using ASCs for skeletal tissue engineering. The aim of this review is to define ASCs, to describe the isolation procedure of ASCs, to review the basic biology of their osteogenic differentiation, discuss cell types and scaffolds available for bone tissue engineering, and finally, to explore imaging of ASCs and their potential future role in human skeletal tissue engineering efforts.
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Cites
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Emerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014)
Chen, C., Dubin, R., & Kim, M. C. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.920813 · Cited by 837
Li, W., Liu, Y., Zhang, P., Tang, Y., Zhou, M., Jiang, W., Zhang, X., Wu, G., & Zhou, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17620 · Cited by 455
PCL‐PEG‐PCL film promotes cartilage regeneration in vivo
Fu, N., Liao, J., Lin, S., Sun, K., Tian, T., Zhu, B., & Lin, Y. (2016) · Cell Proliferation · doi:10.1111/cpr.12295 · Cited by 65
Imamura, A., Kajiya, H., Fujisaki, S., Maeshiba, M., Yanagi, T., Kojima, H., & Ohno, J. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.066 · Cited by 46
Metadata
- Authors
- Levi, B., & Longaker, M. T.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-04-01
- Volume
- 29
- Issue
- 4
- Pages
- 576-582
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2034462307
- Cited by
- 198
- References
- 3
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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