Striatal and extrastriatal dopamine release measured with PET and [18F] fallypride

Slifstein, Mark; Kegeles, Lawrence S.; Xu, Xiaoyan; Thompson, Judy L.; Urban, Nina; Castrillon, John; Hackett, Elizabeth; Bae, S.‐A.; Laruelle, Marc; Abi‐Dargham, Anissa

doi:10.1002/syn.20734

Cited by 115Neurotransmitter Receptor Influence on BehaviorMedical Imaging Techniques and ApplicationsParkinson's Disease Mechanisms and Treatments

Striatal and extrastriatal dopamine release measured with PET and [18F] fallypride

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Slifstein, Mark, Kegeles, Lawrence S., Xu, Xiaoyan, Thompson, Judy L., Urban, Nina, Castrillon, John, Hackett, Elizabeth, Bae, S.‐A. +2 more·2010·Synapse

DOI 10.1002/syn.20734PMC PMC2840194

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Abstract

The amphetamine challenge, in which positron emission tomography (PET) or single photon emission computed tomography radioligand binding following administration of amphetamine is compared to baseline values, has been successfully used in a number of brain imaging studies as an indicator of dopaminergic function, particularly in the striatum. [18 F] fallypride is the first PET radioligand that allows measurement of the effects of amphetamine on D2/D3 ligand binding in striatum and extra‐striatal brain regions in a single scanning session following amphetamine. We scanned 15 healthy volunteer subjects with [18 F] fallypride at baseline and following amphetamine (0.3 mg/kg) using arterial plasma input‐based modeling as well as reference region methods. We found that amphetamine effect was robustly detected in ventral striatum, globus pallidus, and posterior putamen, and with slightly higher variability in other striatal subregions. However, the observed effect sizes in striatum were less than those observed in previous studies in our laboratory using [11 C] raclopride. Robust effect was also detected in limbic extra‐striatal regions (hippocampus, amygdala) and substantia nigra, but the signal‐to‐noise ratio was too low to allow accurate measurement in cortical regions. We conclude that [18 F] fallypride is a suitable ligand for measuring amphetamine effect in striatum and limbic regions, but it is not suitable for measuring the effect in cortical regions and may not provide the most powerful way to measure the effect in striatum. Synapse 64:350–362, 2010. © 2009 Wiley‐Liss, Inc.

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18F-fallypride has a higher affinity than 11C-raclopride and is thus better suited for simultaneous measurement of D2/D3 receptor availability in striatal regions and the midbrain.
“we used PET imaging of 18F-fallypride, which has a higher affinity than 11C-raclopride (the radioligand of choice in all previous dopamine receptor imaging studies in ADHD) and is thus better suited for simultaneous measurement of D2/D3 receptor availability in striatal regions and the midbrain (Riccardi et al., 2006a, b; Cropley et al., 2008; Slifstein et al., 2010).”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Slifstein et al., 2010

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Authors: Slifstein, M., Kegeles, L. S., Xu, X., Thompson, J. L., Urban, N., Castrillon, J., Hackett, E., Bae, S. ‐., Laruelle, M., & Abi‐Dargham, A.
Affiliations: New York State Psychiatric Institute (US)
GlaxoSmithKline (United Kingdom) (GB)
Corresponding author: Slifstein, Mark
ORCID: Slifstein, Mark
Kegeles, Lawrence S.
Thompson, Judy L.
Abi‐Dargham, Anissa
Venue: Synapse
Publisher: Wiley
Published: 2009-12-22
Volume: 64
Issue: 5
Pages: 350-362
ISSN: 0887-4476 (ISSN-L)
1098-2396
DOI: 10.1002/syn.20734
PMC: PMC2840194
OpenAlex: W2085954289
Cited by: 115
References: 57
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 15 · 2012: 11
FWCI: 3.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Synapse (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5p50mh066171-05)
National Institute of Mental Health (MH0661710-03, P50-MH066171)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: [18F]fallypride, amphetamine challenge, dopamine release, striatum, extrastriatal dopamine, ventral striatum, globus pallidus, putamen, substantia nigra, hippocampus, amygdala
MeSH terms: Adult, Amphetamine, Benzamides, Brain, Brain Mapping, Corpus Striatum, Dopamine, Female, Humans, Male, Pyrrolidines, Signal Processing, Computer-Assisted, Dopamine Agents, Raclopride, Positron-Emission Tomography, Young Adult

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Striatal and extrastriatal dopamine release measured with PET and [18F] fallypride

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