Stress-induced dopamine release in human medial prefrontal cortex-18F-Fallypride/PET study in healthy volunteers: Stress-Induced Dopamine Release in m PFC
Abstract
BACKGROUND: In laboratory animals, environmental stressors markedly activate the mesocortical dopamine system. The present study tested whether this occurs in humans. METHODS: The effects of a laboratory psychological stressor (Montreal Imaging Stress Task, MIST) on mesocortical dopamine release in healthy young adults (11 males, mean age ± SD, 20.6 ± 2.4 years) was measured using positron emission tomography and [(18)F]fallypride. Each subject was scanned in two separate days in counterbalanced order: one with the MIST and one with the control task. Binding potential (BP ND ) maps of the whole brain were calculated for each scan, using a simplified reference tissue compartmental model. Then BP ND was compared between subjects. Heart rate, galvanic skin response, and salivary cortisol level were measured during the scans. RESULTS: The psychological stressor significantly decreased [(18)F]fallypride binding values in the dorsal part of the medial prefrontal cortex (dmPFC), corresponding to the rostal part of the cingulate motor zone. The greater the stress-induced decrease in [(18)F]fallypride binding in the dmPFC, the greater the stress-induced increases in heart rate. CONCLUSIONS: The present study provides evidence of stress-induced dopamine release in the mPFC in humans, in vivo.
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Acute stress leads to activation of the dopaminergic system.
“Furthermore, it has been shown that acute stress leads to an activation of the dopaminergic system [23,24]”
From Dynamic DNA methylation changes in the COMT gene promoter region in response to mental stress and its modulation by transcranial direct current stimulation (2021) · cites this paper as [24]
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- Authors
- Nagano-Saito, A., Dagher, A., Booij, L., Gravel, P., Welfeld, K., Casey, K. F., Leyton, M., & Benkelfat, C.
- Affiliations
- McGill University (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Venue
- Synapse
- Publisher
- Wiley
- Published
- 2013-09-12
- Volume
- 67
- Issue
- 12
- Pages
- 821-830
- ISSN
- 0887-4476 (ISSN-L)
- OpenAlex
- W2165296496
- Cited by
- 60
- References
- 66
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 2
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Synapse (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- psychological stress, dopamine release, medial prefrontal cortex, dorsomedial prefrontal cortex, mesocortical dopamine system, Montreal Imaging Stress Task, heart rate, salivary cortisol, skin conductance
- MeSH terms
- Adolescent, Adult, Benzamides, Dopamine, Heart Rate, Humans, Male, Pyrrolidines, Stress, Psychological, Prefrontal Cortex, Positron-Emission Tomography, Healthy Volunteers
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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