Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [11C]raclopride
Open accessAbstract
Background We used a positron emission tomography paradigm with the D2/3 radiotracer [¹¹C]raclopride and an alcohol challenge to examine the magnitude of alcohol-induced dopamine release and compare it between young men and women.Methods Twenty-one nonalcohol-dependent young social drinkers completed two positron emission tomography scans on separate days following ingestion of a juice mix containing either ethanol (.75 mg/kg body water) or trace ethanol only. The extent of dopamine released after alcohol was estimated by the percentage difference in [¹¹C]raclopride binding potential (ΔBP(ND)) between days.Results Alcohol administration significantly displaced [¹¹C]raclopride in all striatal subregions, indicating dopamine release, with the largest effect observed in the ventral striatum. Linear mixed model analysis across all striatal subregions of regional ΔBP(ND) with region of interest as repeated measure showed a highly significant effect of sex (p < .001). Ventrostriatal dopamine release in men, but not in women, showed a significant positive correlation to alcohol-induced measures of subjective activation. Furthermore, we found a significant negative correlation between the frequency of maximum alcohol consumption per 24 hours and ventrostriatal ΔBP(ND) (r = .739, p = .009) in men.Conclusions This study provides definitive evidence that oral alcohol induces dopamine release in nonalcoholic human subjects and shows sex differences in the magnitude of this effect. The ability of alcohol to stimulate dopamine release may contribute to its rewarding effects and, thereby, to its abuse liability in humans. Our report further suggests several biological mechanisms that may mediate the difference in vulnerability for alcoholism between men and women.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In humans, oral doses of alcohol increased extracellular dopamine concentrations during intoxication in healthy volunteers, based on PET measures.
“In humans, consistent with animal studies, oral doses of alcohol increased extracellular dopamine concentrations during intoxication in healthy volunteers, based on positron emission tomography measures (Boileau et al., 2003;Urban et al., 2010).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Urban et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
Hasin, D. S., Stinson, F. S., Ogburn, E., & Grant, B. F. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.7.830 · Cited by 2,908 · see citing works
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968 · see citing works
Watson, P. E., Watson, I. D., & Rd, B. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.1.27 · Cited by 1,477 · see citing works
Mesocorticolimbic dopaminergic network: functional and regulatory roles
Moal, M. L., & Simon, H. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.155 · Cited by 1,096 · see citing works
Schuckit, M. A. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60009-x · Cited by 715 · see citing works
Development and Validation of the Biphasic Alcohol Effects Scale
Martin, C. S., Earleywine, M., Musty, R. E., Perrine, M. W., & Swift, R. M. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00739.x · Cited by 683 · see citing works
Alcohol promotes dopamine release in the human nucleus accumbens
Boileau, I., Assaad, J., Pihl, R. O., Benkelfat, C., Leyton, M., Diksic, M., Tremblay, R. E., & Dagher, A. (2003) · Synapse · doi:10.1002/syn.10226 · Cited by 591 · see citing works
Martinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y., Cooper, T., Kegeles, L., Zarahn, E., Abi-Dargham, A., et al. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048520.34839.1a · Cited by 569 · see citing works
Self-citationComputational anatomy with the SPM software
Ashburner, J. (2009) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2009.01.006 · Cited by 565 · see citing works
Mawlawi, O., Martinez, D., Slifstein, M., Broft, A., Chatterjee, R., Hwang, D.-R., Huang, Y., Simpson, N., Ngo, K., Van Heertum, R., et al. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200109000-00002 · Cited by 525 · see citing works
Self-citationVolkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Jayne, M., Ma, Y., Pradhan, K., & Wong, C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3371-07.2007 · Cited by 494 · see citing works
Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
Martinez, D., Gil, R., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Kegeles, L., Talbot, P., Evans, S., Krystal, J., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.044 · Cited by 445 · see citing works
Self-citationDistribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain
Hall, H., Sedvall, G., Magnusson, O., Kopp, J., Halldin, C., & Farde, L. (1994) · Neuropsychopharmacology · doi:10.1038/sj.npp.1380111 · Cited by 441 · see citing works
Sulzer, D., & Rayport, S. (1990) · Neuron · doi:10.1016/0896-6273(90)90339-h · Cited by 389 · see citing works
Sex differences in striatal dopamine release in healthy adults.
Munro, C. A., Mccaul, M., Wong, D., Oswald, L., Zhou, Y., Brašić, J. R., Kuwabara, H., Kumar, A., Alexander, M., Ye, W., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.008 · Cited by 364 · see citing works
Drugs and Reinforcement Mechanisms: A Critical Review of the Catecholamine Theory
Fibiger, H. C. (1978) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.18.040178.000345 · Cited by 293 · see citing works
The Collaborative Study on the Genetics of Alcoholism.
Begleiter, H., Reich, T., HESSELBROCK, V. M., & Bernice Porjesz, A. (1995) · PubMed Central · Cited by 276 · see citing works
Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans
Laruelle, M. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00043-2 · Cited by 266 · see citing works
Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats
Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90026-0 · Cited by 257 · see citing works
The role of affective processes in learning and motivation.
Young, P. T. (1959) · Psychological Review · doi:10.1037/h0045997 · Cited by 229 · see citing works
Brain SPECT Imaging of Amphetamine-Induced Dopamine Release in Euthymic Bipolar Disorder Patients
Anand, A., Verhoeff, P., Seneca, N., Zoghbi, S. S., Seibyl, J. P., Charney, D. S., & Innis, R. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1108 · Cited by 222 · see citing works
Ventral Striatal Dopamine Release in Response to Smoking a Regular vs a Denicotinized Cigarette
Brody, A. L., Mandelkern, M. A., Olmstead, R. E., Allen-Martinez, Z., Scheibal, D., Abrams, A. L., Costello, M. R., Farahi, J., Saxena, S., Monterosso, J., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.87 · Cited by 183 · see citing works
The natural history of adolescent alcohol use disorders
Clark, D. B. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00851.x · Cited by 172 · see citing works
Release of dopamine via the human transporter.
Eshleman, A., Henningsen, R. A., Neve, K., & Janowsky, A. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09929-8 · Cited by 168 · see citing works
Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats
McBride, W. J., Chernet, E., Dyr, W., Lumeng, L., & Li, T.-K. (1993) · Alcohol · doi:10.1016/0741-8329(93)90025-j · Cited by 160 · see citing works
Mereu, G., & Gessa, G. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)91249-1 · Cited by 154 · see citing works
Focal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis study
Wozniak, K. M., Pert, A., Mele, A., & Linnoila, M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90489-i · Cited by 147 · see citing works
The histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects
Schuckit, M. A., TIPP, J. E., Reich, T., HESSELBROCK, V. M., & Bucholz, K. K. (2003) · Addiction · doi:10.1046/j.1360-0443.1995.901013355.x · Cited by 141 · see citing works
Alcohol Self‐Administration: Role of Mesolimbic Dopaminea
Samson, H. H., Tolliver, G. A., Haraguchi, M., & Hodge, C. W. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25971.x · Cited by 125 · see citing works
Mechanism of action of cocaine and amphetamine in the brain
van Rossum, J. M., van der Schoot, J. B., & Hurkmans, J. A. T. M. (1962) · Cellular and Molecular Life Sciences · doi:10.1007/bf02148316 · Cited by 122 · see citing works
Yim, H. J., Schallert, T. J., Randall, P. K., & Gonzales, R. A. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03662.x · Cited by 116 · see citing works
Striatal and extrastriatal dopamine release measured with PET and [<sup>18</sup>F] fallypride
Slifstein, M., Kegeles, L. S., Xu, X., Thompson, J. L., Urban, N., Castrillon, J., Hackett, E., Bae, S. ‐., Laruelle, M., & Abi‐Dargham, A. (2010) · Synapse · doi:10.1002/syn.20734 · Cited by 115 · see citing works
Self-citationThe histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects
Schuckit, M. A., TIPP, J. E., Reich, T., HESSELBROCK, V. M., & Bucholz, K. K. (1995) · Addiction · doi:10.1111/j.1360-0443.1995.tb03551.x · Cited by 108 · see citing works
Teesson, M., Baillie, A., Lynskey, M. T., Manor, B. R., & Degenhardt, L. J. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.06.007 · Cited by 90 · see citing works
Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study.
Yoder, K., Constantinescu, C., Kareken, D., Normandin, M., Cheng, T., O'Connor, S., & Morris, E. (2007) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00390.x · Cited by 89 · see citing works
Katner, S. N., & Weiss, F. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02199.x · Cited by 85 · see citing works
Ethanol Excitation of Dopaminergic Ventral Tegmental Area Neurons Is Blocked by Quinidine
Appel, S. B., Liu, Z., McElvain, M. A., & Brodie, M. S. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.050963 · Cited by 82 · see citing works
Doyon, W. M., Anders, S. K., Ramachandra, V. S., Czachowski, C. L., & Gonzales, R. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03137.x · Cited by 79 · see citing works
Murphy, J. M., McBride, W. J., Gatto, G. J., Lumeng, L., & Li, T. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90291-2 · Cited by 78 · see citing works
Maisto, S. A., Sobell, L. C., Cooper, A. M., & Sobell, M. B. (1982) · Addictive Behaviors · doi:10.1016/0306-4603(82)90022-3 · Cited by 73 · see citing works
Abi-Dargham, A., Kegeles, L., Martinez, D., Innis, R., & Laruelle, M. (2003) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.08.007 · Cited by 73 · see citing works
Self-citationA PET study of D2 dopamine receptor density at different phases of the menstrual cycle
Nordström, A., Olsson, H., & Halldin, C. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00021-3 · Cited by 72 · see citing works
Relationship of Age of First Drink to Child Behavioral Problems and Family Psychopathology
Samuel Kuperman, C., Chan, G., Kramer, J., Bierut, L. J., Bucholz, K. K., Fox, L. W., HESSELBROCK, V. M., Nürnberger, J. I., Reich, T., Reich, W., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000183190.32692.c7 · Cited by 68 · see citing works
Howard, E. C., Schier, C. J., Wetzel, J., Duvauchelle, C. L., & Gonzales, R. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.014 · Cited by 64 · see citing works
Yoder, K. K., Morris, E. D., Constantinescu, C. C., Cheng, T., Normandin, M. D., O’Connor, S., & Kareken, D. A. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00821.x · Cited by 64 · see citing works
Bustamante, D., Quintanilla, M. E., Tampier, L., González-Lira, V., Israel, Y., & Herrera‐Marschitz, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.069 · Cited by 55 · see citing works
Age‐related loss of extrastriatal dopamine D2‐like receptors in women
Kaasinen, V., Kemppainen, N. M., Någren, K., Helenius, H. Y. M., Kurki, T. J. I., & Rinne, J. O. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00895.x · Cited by 51 · see citing works
Keyes, K. M., Geier, T. J., Grant, B. F., & Hasin, D. S. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00894.x · Cited by 42 · see citing works
Ramachandra, V. S., Phuc, S., Franco, A. C., & Gonzales, R. A. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00463.x · Cited by 41 · see citing works
Effect of ethanol on [3H]Dopamine release in rat nucleus accumbens and striatal slices
Russell, V. A., Lamm, M. C. L., & Taljaard, J. J. F. (1988) · Neurochemical Research · doi:10.1007/bf01268885 · Cited by 41 · see citing works
Dopamine Release During Ethanol Drinking in AA Rats
Nurmi, M., Sinclair, J. D., & Kiianmaa, K. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03959.x · Cited by 31 · see citing works
Alcohol, Europe and the developing countries
Saxena, S. (1997) · Addiction · doi:10.1111/j.1360-0443.1997.tb03394.x · Cited by 30 · see citing works
Effect of Ethanol on Extracellular Dopamine in Rat Striatum by Direct Perfusion with Microdialysis
Yim, H. J., Schallert, T. J., Randall, P. K., Bungay, P. M., & Gonzales, R. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68041527.x · Cited by 21 · see citing works
Immune Disturbances in Treatment-Resistant Depression: Modulation by Antidepressive Treatments
Maes, M. H. J., Vandoolaeghe, E., Hunsel, F. V., Bril, T., Demedts, P., Wauters, A., & Neels, H. M. (1997) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(199703/04)12:2 · Cited by 19 · see citing works
Alcohol, Europe and the developing countries
Saxena, S. (1997) · Addiction · doi:10.1046/j.1360-0443.92.3s1.10.x · Cited by 15 · see citing works
Snape, B. M., & Engel, J. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90003-2 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Narendran, 2004, Measurement of in vivo affinity of [11C]NPA and the proportion of D2 receptors configured in agonist high affinity state (%Rhigh) in baboons using PET, Neuroimage, 22, T19
Cited by
Sorted by citations
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
Sex and gender differences in substance use disorders
McHugh, R. K., Votaw, V. R., Sugarman, D. E., & Greenfield, S. F. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.10.012 · Cited by 1,076 · see citing works
Erol, A., & Karpyak, V. M. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.08.023 · Cited by 1,022 · see citing works
Carvalho, A. F., Heilig, M. A., Perez, A., Probst, C., & Rehm, J. T. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31775-1 · Cited by 678 · see citing works
The dopamine theory of addiction: 40 years of highs and lows
Nutt, D., Lingford-Hughes, A. R., Erritzøe, D., & Stokes, P. R. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3939 · Cited by 647 · see citing works
How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission
Sulzer, D. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.010 · Cited by 573 · see citing works
Leeman, R. F., & Potenza, M. N. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2550-7 · Cited by 448 · see citing works
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works
The dopamine hypothesis of drug addiction and its potential therapeutic value
Diana, M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00064 · Cited by 251 · see citing works
Hazardous drinking and alcohol use disorders
MacKillop, J. M., Agabio, R., Ewing, S. W. F., Heilig, M. A., Kelly, J. F., Leggio, L., Lingford-Hughes, A. R., Palmer, A. A., Parry, C. D. H., Ray, L. A., et al. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00406-1 · Cited by 235 · see citing works
Duko, B., Ayalew, M., & Ayano, G. (2019) · Substance Abuse Treatment, Prevention, and Policy · doi:10.1186/s13011-019-0240-3 · Cited by 209 · see citing works
Emergence of sex differences in the development of substance use and abuse during adolescence
Kuhn, C. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.003 · Cited by 182 · see citing works
Dopamine and addiction: what have we learned from 40 years of research
Solinas, M., Belujon, P., Fernagut, P., Jaber, M., & Thiriet, N. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1957-2 · Cited by 155 · see citing works
Towers, E. B., Williams, I. L., Qillawala, E. I., Rissman, E. F., & Lynch, W. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000361 · Cited by 149 · see citing works
Neurobiology of comorbid post‐traumatic stress disorder and alcohol‐use disorder
Gilpin, N. W., & Weiner, J. L. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12349 · Cited by 147 · see citing works
Sex hormone activity in alcohol addiction: Integrating organizational and activational effects
Lenz, B., Müller, C. P., Stoessel, C., Sperling, W., Biermann, T., Hillemacher, T., Bleich, S., & Kornhuber, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.11.001 · Cited by 136 · see citing works
Bossong, M., Mehta, M., van Berckel, B. N., Howes, O., Kahn, R., & Stokes, P. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3915-0 · Cited by 138 · see citing works
Oswald, L. M., Wand, G. S., Kuwabara, H., Wong, D. F., Zhu, S., & Brasic, J. R. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3407-z · Cited by 114 · see citing works
Söderpalm, B., & Ericson, M. (2011) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28720-6_170 · Cited by 117 · see citing works
Dopamine Release in Chronic Cannabis Users: A [11C]Raclopride Positron Emission Tomography Study
Urban, N., Slifstein, M., Thompson, J. L., Xu, X., Girgis, R. R., Raheja, S., Haney, M., & Abi‐Dargham, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.018 · Cited by 114 · see citing works
Self-citationVolkow, N. D., Wiers, C. E., Kojori, E. S., Tomasi, D. G., Wang, G., & Baler, R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.012 · Cited by 105 · see citing works
Gut-brain axis and addictive disorders: A review with focus on alcohol and drugs of abuse
Jerlhag, E. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.005 · Cited by 92 · see citing works
Wium‐Andersen, I. K., Wium‐Andersen, M. K., Fink‐Jensen, A., Rungby, J., Jørgensen, M. B., & Osler, M. (2022) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13776 · Cited by 93 · see citing works
Evidence for incentive salience sensitization as a pathway to alcohol use disorder
Cofresí, R. U., Bartholow, B. D., & Piasecki, T. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.009 · Cited by 90 · see citing works
Role of cannabinoid CB2receptor in the reinforcing actions of ethanol
Ortega-Álvaro, A., Ternianov, A., Aracil-Fernández, A., Navarrete, F., García‐Gutiérrez, M. S., & Manzanares, J. (2013) · Addiction Biology · doi:10.1111/adb.12076 · Cited by 83 · see citing works
Transition to substance use disorders: impulsivity for reward and learning from reward
Poulton, A., & Hester, R. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz077 · Cited by 79 · see citing works
Dopamine Receptor Activation Increases HIV Entry into Primary Human Macrophages
Gaskill, P. J., Yano, H., Kalpana, G. V., Javitch, J. A., & Berman, J. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108232 · Cited by 80 · see citing works
Barker, J. M., & Taylor, J. R. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.027 · Cited by 84 · see citing works
Oberlin, B. G., Džemidžić, M., Tran, S. M., Soeurt, C. M., Albrecht, D., Yoder, K. K., & Kareken, D. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.91 · Cited by 79 · see citing works
Yoder, K. K., Albrecht, D., Džemidžić, M., Normandin, M. D., Federici, L. M., Graves, T., Herring, C. M., Hile, K. L., Walters, J. W., Liang, T., et al. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.01.001 · Cited by 73 · see citing works
Vallöf, D., Kalafateli, A. L., & Jerlhag, E. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00923-1 · Cited by 74 · see citing works
Verplaetse, T. L., Cosgrove, K., Tanabe, J., & McKee, S. A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24625 · Cited by 71 · see citing works
GLP-1 signaling and alcohol-mediated behaviors; preclinical and clinical evidence
Jerlhag, E. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.013 · Cited by 72 · see citing works
King, A. C., Cao, D., O’Malley, S. S., Kranzler, H. R., Cai, X., de Wit, H., Matthews, A. K., & Stachoviak, R. J. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182676956 · Cited by 70 · see citing works
Self-citationNecho, M., Belete, A., & Getachew, Y. (2020) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/s13011-020-00301-6 · Cited by 67 · see citing works
Prefrontal cortical dopamine transmission is decreased in alcoholism
Narendran, R., Mason, N., Paris, J., Himes, M. L., Douaihy, A., & Frankle, W. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13121581 · Cited by 69 · see citing works
Feltmann, K., Borroto‐Escuela, D. O., Rüegg, J., Pinton, L., de Oliveira Sergio, T., Narváez, M., Jimenez‐Beristain, A., Ekström, T. J., Fuxe, K., & Steensland, P. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13568 · Cited by 67 · see citing works
Weiland, B., Heitzeg, M., Zald, D., Cummiford, C. M., Love, T. M., Zucker, R., & Zubieta, J. (2014) · Psychiatry Research · doi:10.1016/j.pscychresns.2014.05.015 · Cited by 60 · see citing works
Blaine, S. K., Wemm, S., Fogelman, N., Lacadie, C., Seo, D., Scheinost, D., & Sinha, R. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19070703 · Cited by 63 · see citing works
Sex differences in impulsive and compulsive behaviors: a focus on drug addiction
Fattore, L., & Melis, M. (2016) · Addiction Biology · doi:10.1111/adb.12381 · Cited by 62 · see citing works
Schulte, T., Oberlin, B. G., Kareken, D. A., Marinković, K., Müller‐Oehring, E. M., Meyerhoff, D. J., & Tapert, S. F. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01831.x · Cited by 60 · see citing works
Bilbao, A., Robinson, J. E., Heilig, M. A., Malanga, C. J., Spanagel, R., Sommer, W. H., & Thorsell, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.021 · Cited by 58 · see citing works
Sex differences in alcohol-related neurobehavioral consequences
Nixon, S. J., Prather, R. A., & Lewis, B. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00016-1 · Cited by 55 · see citing works
Engel, J. A., & Jerlhag, E. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63425-2.00009-x · Cited by 50 · see citing works
Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol
Cui, C., & Koob, G. F. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.03.002 · Cited by 50 · see citing works
Hansson, A. C., Gründer, G., Hirth, N., Noori, H. R., Spanagel, R., & Sommer, W. H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.010 · Cited by 49 · see citing works
Setiawan, E., Pihl, R. O., Dagher, A., Schlagintweit, H. E., Casey, K. F., Benkelfat, C., & Leyton, M. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12218 · Cited by 47 · see citing works
Stock, A., Schulz, T., Lenhardt, M., Blaszkewicz, M., & Beste, C. (2014) · Addiction Biology · doi:10.1111/adb.12170 · Cited by 44 · see citing works
Making Sense of: Sensitization in Schizophrenia
Weidenauer, A., Bauer, M., Sauerzopf, U., Bartova, L., Praschak-rieder, N., Sitte, H., Kasper, S., & Willeit, M. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw081 · Cited by 44 · see citing works
Striatal alcohol cue‐reactivity is stronger in male than female problem drinkers
Kaag, A. M., Wiers, R. W. H. J., Vries, T. J. D., Pattij, T., & Goudriaan, A. E. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13991 · Cited by 44 · see citing works
Laruelle, M. (2012) · Neuromethods · doi:10.1007/7657_2012_45 · Cited by 40 · see citing works
Multi-scale neural decoding and analysis
Lu, H., Lorenc, E. S., Zhu, H., Kilmarx, J., Sulzer, J. S., Xie, C., Tobler, P. N., Watrous, A. J., Orsborn, A. L., Lewis‐Peacock, J. A., et al. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac160f · Cited by 41 · see citing works
Koob, G. F., & Vendruscolo, L. F. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_424 · Cited by 44 · see citing works
Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism
Enoch, M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.001 · Cited by 43 · see citing works
Aalto, S., Ingman, K., Alakurtti, K., Kaasinen, V., Virkkala, J., Någren, K., Rinne, J. O., & Scheinin, H. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.209 · Cited by 42 · see citing works
The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research
Heilig, M. A., Sommer, W. H., & Spanagel, R. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5006 · Cited by 42 · see citing works
Oberlin, B. G., Džemidžić, M., Tran, S. M., Soeurt, C. M., O’Connor, S., Yoder, K. K., & Kareken, D. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3720-1 · Cited by 41 · see citing works
Spreckelmeyer, K. N., Paulzen, M., Raptis, M., Baltus, T., Schaffrath, S., Waesberghe, J. V., Zalewski, M. M., Rösch, F., Vernaleken, I., Schäfer, W. M., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.035 · Cited by 41 · see citing works
Opioid–Dopamine Interactions: Implications for Substance Use Disorders and Their Treatment
Volkow, N. D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.002 · Cited by 41 · see citing works
The stress–response-dampening effects of placebo
Balodis, I. M., Wynne-Edwards, K. E., & Olmstead, M. C. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.01.004 · Cited by 39 · see citing works
Stimulant and motivational effects of alcohol: Lessons from rodent and primate models
Brabant, C., Guarnieri, D. J., & Quertemont, É. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.006 · Cited by 38 · see citing works
Necho, M., Tsehay, M., Seid, M., Zenebe, Y., Belete, A., Gelaye, H., & Muche, A. (2021) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/s13011-020-00335-w · Cited by 36 · see citing works
Genders and the concurrent use of cocaine and alcohol: Pharmacological aspects
Graziani, M., Nencini, P., & Nisticò, R. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.06.009 · Cited by 36 · see citing works
Leurquin‐Sterk, G., Ceccarini, J., Crunelle, C. L., Weerasekera, A., de Laat, B., Himmelreich, U., Bormans, G. M., & Laere, K. V. (2017) · Addiction Biology · doi:10.1111/adb.12542 · Cited by 36 · see citing works
Conditioned Preference to a Methamphetamine-Associated Contextual Cue in Humans
Mayo, L. M., Fraser, D., Childs, E., Momenan, R., Hommer, D. W., de Wit, H., & Heilig, M. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.3 · Cited by 36 · see citing works
Effects of binge drinking on action cascading processes: an EEG study
Stock, A., Blaszkewicz, M., & Beste, C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1109-2 · Cited by 35 · see citing works
Eckschmidt, F., de Andrade, A. G., & de Oliveira, L. G. (2013) · Jornal Brasileiro de Psiquiatria · doi:10.1590/s0047-20852013000300004 · Cited by 35 · see citing works
Petit, G., Kornreich, C., Dan, B., Verbanck, P., & Campanella, S. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114545663 · Cited by 35 · see citing works
Urban, N., & Martínez, D. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.03.011 · Cited by 33 · see citing works
Self-citationDumais, K. M., Franklin, T. R., Jagannathan, K., Hager, N., Gawrysiak, M. J., Betts, J. M., Farmer, S. L., Guthier, E., Pater, H. A., Janes, A. C., et al. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.05.044 · Cited by 34 · see citing works
Cannabinoids, reward processing, and psychosis
Gunasekera, B., Diederen, K. M. J., & Bhattacharyya, S. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05801-2 · Cited by 33 · see citing works
The nucleus accumbens and alcoholism: a target for deep brain stimulation
Ho, A. L., Salib, A.-M. N., Pendharkar, A. V., Sussman, E. S., Giardino, W. J., & Halpern, C. H. (2018) · Neurosurgical FOCUS · doi:10.3171/2018.5.focus18157 · Cited by 34 · see citing works
Acute effects of alcohol on social and personal decision making
Karlsson, H., Persson, E., Perini, I., Yngve, A., Heilig, M. A., & Tinghög, G. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01218-9 · Cited by 33 · see citing works
Dopaminergic System Dysfunction in Recreational Dexamphetamine Users
Schrantee, A., Václavů, L., Heijtel, D., Caan, M. W. A., Gsell, W., Lucassen, P. J., Nederveen, A. J., Booij, J., & Reneman, L. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.301 · Cited by 31 · see citing works
Dopamine and Alcohol Dependence: From Bench to Clinic
Jayaram‐Lindström, N., Ericson, M., Steensland, P., & Jerlhag, E. (2016) · InTech eBooks · doi:10.5772/63144 · Cited by 30 · see citing works
COMT Associations with Disordered Gambling and Drinking Measures
Guillot, C. R., Fanning, J. R., Liang, T., & Berman, M. E. (2014) · Journal of Gambling Studies · doi:10.1007/s10899-013-9434-1 · Cited by 29 · see citing works
Weiland, B. J., Zucker, R. A., Zubieta, J., & Heitzeg, M. M. (2016) · Addiction Biology · doi:10.1111/adb.12341 · Cited by 29 · see citing works
Closing the Gender Gap: The Case for Gender-Specific Alcoholism Research
Ruiz, S. M. (2013) · Journal of Alcoholism and Drug Dependence · doi:10.4172/2329-6488.1000e106 · Cited by 28 · see citing works
Striatal activation to monetary reward is associated with alcohol reward sensitivity
Radoman, M., Crane, N. A., Gorka, S. M., Weafer, J. J., Langenecker, S. A., de Wit, H., & Phan, K. L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0728-6 · Cited by 25 · see citing works
What the alcohol doctor ordered from the neuroscientist
Heilig, M., & Leggio, L. (2016) · Progress in Brain Research · doi:10.1016/bs.pbr.2015.07.023 · Cited by 25 · see citing works
Kegeles, L. S., Horga, G., Ghazzaoui, R., Rosengard, R., Ojeil, N., Xu, X., Slifstein, M., Petrakis, I. L., O’Malley, S. S., Krystal, J. H., et al. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.03.018 · Cited by 25 · see citing works
Self-citationKaag, A. M., Reneman, L., Homberg, J. R., van den Brink, W., & van Wingen, G. A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00070 · Cited by 25 · see citing works
Paradox effects of binge drinking on response inhibition processes depending on mental workload
Stock, A., Riegler, L., Chmielewski, W. X., & Beste, C. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1565-y · Cited by 24 · see citing works
Sex Differences in Alcohol Use: Is It All About Hormones?
Maddern, X. J., Ursich, L. T., Bailey, G., Pearl, A. J., Anversa, R. G., Lawrence, A. J., & Walker, L. C. (2024) · Endocrinology · doi:10.1210/endocr/bqae088 · Cited by 23 · see citing works
Toxicological properties of Δ 9 -tetrahydrocannabinol and cannabidiol
Černe, K. (2020) · Archives of Industrial Hygiene and Toxicology · doi:10.2478/aiht-2020-71-3301 · Cited by 23 · see citing works
Dahchour, A., & Ward, R. J. (2021) · Alcohol and Alcoholism · doi:10.1093/alcalc/agab072 · Cited by 23 · see citing works
Setiawan, E., Pihl, R. O., Benkelfat, C., & Leyton, M. (2012) · Pharmacogenomics · doi:10.2217/pgs.12.99 · Cited by 23 · see citing works
Use of psychotropic drugs by students from the health area: a comparative and qualitative analysis
Tovani, J. B. E., Santi, L. J., & Trindade, E. V. (2021) · Revista Brasileira de Educação Médica · doi:10.1590/1981-5271v45.3-20200485.ing · Cited by 21 · see citing works
Striatal dopamine D2-type receptor availability and peripheral 17β-estradiol
Petersen, N., Rapkin, A. J., Okita, K., Kinney, K. R., Mizuno, T., Mandelkern, M. A., & London, E. D. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-01000-1 · Cited by 21 · see citing works
Liu, Y., & Zhang, H. (2022) · Genes · doi:10.3390/genes13060958 · Cited by 21 · see citing works
Sex- and Gender-Specific Drug Abuse Dynamics: The Need for Tailored Therapeutic Approaches
Marinelli, S., Basile, G., Manfredini, R., & Zaami, S. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13060965 · Cited by 21 · see citing works
Molecular imaging in alcohol dependence
Ravan, S., Martínez, D., Slifstein, M., & Abi‐Dargham, A. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00018-5 · Cited by 21 · see citing works
Self-citationFransquet, P., Hutchinson, D. M., Olsson, C. A., Wilson, J., ALLSOP, S. J., Najman, J. M., Elliott, E. J., Mattick, R. P., Saffery, R., & Ryan, J. L. (2016) · Current Zoology · doi:10.1093/eep/dvw023 · Cited by 21 · see citing works
Jeong, H. S., Park, S., Lim, S. M., Ma, J., Kang, I., Kim, J., Kim, E., Choi, Y. J., Lim, J.-H., Chung, Y., et al. (2017) · Substance Use & Misuse · doi:10.1080/10826084.2016.1271986 · Cited by 21 · see citing works
Sex and Age Effects on Neurobehavioral Toxicity Induced by Binge Alcohol
Cortez, I., Rodgers, S. P., Kosten, T. A., & Leasure, J. L. (2020) · Brain Plasticity · doi:10.3233/bpl-190094 · Cited by 21 · see citing works
Sensory cue reactivity: Sensitization in alcohol use disorder and obesity
Agarwal, K., Manza, P., Leggio, L., Livinski, A. A., Volkow, N. D., & Joseph, P. V. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.014 · Cited by 19 · see citing works
Addiction and dopamine: sex differences and insights from studies of smoking
Petersen, N., & London, E. D. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.07.002 · Cited by 18 · see citing works
Thiruchselvam, T., Malik, S., & Foll, B. L. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1257633 · Cited by 22 · see citing works
Alcohol Consumption in HealthyOPRM1G Allele Carriers and Its Association with Impulsive Behavior
Pfeifer, P., Sariyar, M., Eggermann, T., Zerres, K., Vernaleken, I., Tüscher, O., & Fehr, C. (2015) · Alcohol and Alcoholism · doi:10.1093/alcalc/agv019 · Cited by 17 · see citing works
Heilig, M. A. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13636 · Cited by 17 · see citing works
- Authors
- Urban, N. B. L., Kegeles, L. S., Slifstein, M., Xu, X., Martinez, D., Sakr, E., Castillo, F., Moadel, T., O'Malley, S. S., Krystal, J. H., & Abi-Dargham, A.
- Affiliations
- New York State Psychiatric Institute (US)
- Yale University (US)
- Corresponding author
- Urban, Nina B.L.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 68
- Issue
- 8
- Pages
- 689-696
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2949533
- OpenAlex
- W2014500606
- Cited by
- 223
- References
- 57
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 12 · 2022: 12 · 2021: 18 · 2020: 34 · 2019: 12 · 2018: 15 · 2017: 15 · 2016: 13 · 2015: 11 · 2014: 22 · 2013: 11 · 2012: 8
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism
- Yale University (P50AA-012870-09)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- sex differences, dopamine release, striatum, alcohol challenge, [11C]raclopride, ventral striatum, alcohol reward, drinking frequency, young adults
- MeSH terms
- Adult, Alcohol Drinking, Carbon Radioisotopes, Corpus Striatum, Dopamine, Female, Humans, Male, Radioligand Assay, Sex Characteristics, Raclopride, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
