Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

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SOX10 mutations in patients with Waardenburg-Hirschsprung disease

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Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

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SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells.

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Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature

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Sox10: A Pan-Schwannian and Melanocytic Marker

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Pax3 functions at a nodal point in melanocyte stem cell differentiation

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Mutation of the Sry-related Sox10 gene in Dominant megacolon , a mouse model for human Hirschsprung disease

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Congenital Melanocytic Nevi Frequently Harbor NRAS Mutations but no BRAF Mutations

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Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling

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Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth

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Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

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Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin

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Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61K on an INK4a-Deficient Background

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Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage

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Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling

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Characterization of melanocyte‐specific inducible Cre recombinase transgenic mice

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Generation of melanocytes from neural crest cells

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The Sox10Dom Mouse: Modeling the Genetic Variation of Waardenburg-Shah (WS4) SyndromePreprint

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Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease

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Functional Analysis of Sox10 Mutations Found in Human Waardenburg-Hirschsprung Patients

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High Frequency of BRAF Mutation in Acquired Nevi and Small Congenital Nevi, but Low Frequency of Mutation in Medium-Sized Congenital Nevi

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Consistent expression of the stem cell renewal factor BMI‐1 in primary and metastatic melanoma

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A Molecular Analysis of the Yemenite Deaf-Blind Hypopigmentation Syndrome: SOX10 Dysfunction Causes Different Neurocristopathies

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The transcription factor Sox5 modulates Sox10 function during melanocyte development

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Transforming Growth Factor β-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells

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Nestin and SOX9 and SOX10 transcription factors are coexpressed in melanoma

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The discovery of the microphthalmia locus and its gene, Mitf

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Genetics and genomics of melanoma

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SOX9 and SOX10 but Not BRN2 Are Required for Nestin Expression in Human Melanoma Cells

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SOX10 expression in superficial spreading and nodular malignant melanomas

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Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

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Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

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The role of SOX family members in solid tumours and metastasis

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MITF-the first 25 years

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The melanocyte lineage in development and disease

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A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

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Signal pathways of melanoma and targeted therapy

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The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors

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The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy

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Microphthalmia‐associated transcription factor in melanoma development and MAP ‐kinase pathway targeted therapy

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Pathways and therapeutic targets in melanoma

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Neurocristopathies: New insights 150 years after the neural crest discovery

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Melanoma models for the next generation of therapies

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Injury-activated glial cells promote wound healing of the adult skin in mice

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SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis

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Genetics of melanocytic nevi

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NRAS mutant melanoma: biological behavior and future strategies for therapeutic management

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Developmental chromatin programs determine oncogenic competence in melanoma

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Insights into neural crest development and evolution from genomic analysisPreprint

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The melanocyte lineage in development and disease

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Beyond MITF : Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma

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Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma

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RAB7 Controls Melanoma Progression by Exploiting a Lineage-Specific Wiring of the Endolysosomal Pathway

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A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors

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The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis

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SOX10 Ablation Arrests Cell Cycle, Induces Senescence, and Suppresses Melanomagenesis

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Developmental pathways activated in melanocytes and melanoma

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Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype

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Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis

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Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma

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Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma

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The Nerve Growth Factor Receptor CD271 Is Crucial to Maintain Tumorigenicity and Stem-Like Properties of Melanoma Cells

Redmer, T., Welte, Y., Behrens, D., Fichtner, I., Przybilla, D., Wruck, W., Yaspo, M., Lehrach, H. R., Schäfer, R., & Regenbrecht, C. R. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092596 · Cited by 98 · see citing works

SOX10 Promotes Melanoma Cell Invasion by Regulating Melanoma Inhibitory Activity

Graf, S. A., Busch, C., Bosserhoff, A., Besch, R., & Berking, C. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.128 · Cited by 90 · see citing works

Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas

Ivanov, S. V., Panaccione, A., Nonaka, D., Prasad, M. L., Boyd, K. L., Brown, B. T., Guo, Y. P., Sewell, A. B., & Yarbrough, W. G. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.326 · Cited by 89 · see citing works

SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains

Huang, Y.-H., Jankowski, A., Cheah, K. S. E., Prabhakar, S., & Jauch, R. (2015) · Scientific Reports · doi:10.1038/srep10398 · Cited by 86 · see citing works

Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia

Xu, X., Zhang, D., Kong, P., Gao, Y., Huang, X.-F., Song, Y., Zhang, W., Guo, R., Li, C., Chen, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112869 · Cited by 86 · see citing works

ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma

Han, S., Ren, Y., He, W., Liu, H., Zhi, Z., Zhu, X., Yang, T., Rong, Y., Ma, B., Purwin, T. J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02354-x · Cited by 80 · see citing works

The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer

Patel, S. A., Hirosue, S., Rodrigues, P., Vojtasova, E., Richardson, E. K., Ge, J., Syafruddin, S. E., Speed, A., Papachristou, E. K., Baker, D., et al. (2022) · Nature · doi:10.1038/s41586-022-04809-8 · Cited by 83 · see citing works

The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma

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Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation

Kim, H., Frederick, D. T., Levesque, M. P., Cooper, Z. A., Feng, Y., Krepler, C., Brill, L. M., Samuels, Y., Hayward, N. K., Perlina, A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.049 · Cited by 77 · see citing works

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity

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Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

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Whole‐exome sequencing of oral mucosal melanoma reveals mutational profile and therapeutic targets

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MITF -High and MITF -Low Cells and a Novel Subpopulation Expressing Genes of Both Cell States Contribute to Intra- and Intertumoral Heterogeneity of Primary Melanoma

Ennen, M., Keime, C., Gambi, G., Kieny, A., Coassolo, S., Thibault-Carpentier, C., Margerin-Schaller, F., Davidson, G., Vagne, C., Lipsker, D. M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0010 · Cited by 73 · see citing works

SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/β-catenin pathway

Tong, X., Li, L., Li, X., Lei, H., Zhong, L., Su, X., Rong, R., Hu, S., Liu, W., Jia, B., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2512 · Cited by 70 · see citing works

A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates

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A Review of the Molecular Pathways Involved in Resistance to BRAF Inhibitors in Patients with Advanced-Stage Melanoma

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Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells

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SOX9 is a dose-dependent metastatic fate determinant in melanoma

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LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction

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SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects

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Sox2 is dispensable for primary melanoma and metastasis formation

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Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential

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SOX10-MITF pathway activity in melanoma cells

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Abstract 1743: SOX10 is required for cell cycle regulation and melanomagenesis.

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Melanocytes and the Transcription Factor Sox10

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