Repression of CDC28 reduces the expression of the morphology‐related transcription factors, Efg1p, Nrg1p, Rbf1p, Rim101p, Fkh2p and Tec1p and induces cell elongation in Candida albicans
Abstract
The ability of the human fungal pathogen Candida albicans to transit its cell shape is important for its pathogenicity. To obtain additional evidence that the cell cycle of C. albicans is associated with its morphology, we generated and characterized a conditional mutant of C. albicans CDC28, a cyclin‐dependent kinase. In the constructed strain, the expression of CDC28 was regulated by the MET3 promoter and could be repressed in the presence of methionine and cysteine. Cdc28p‐depleted cells demonstrated highly polarized growth and wider filaments than serum‐induced hyphae. Hyphae‐specific genes, HWP1, RBT4 and ECE1, were activated in the elongated filaments caused by the Cdc28p depletion. Furthermore, the protein expression levels of the transcription factors involved in morphological transition, Efg1p, Nrg1p, Rbf1p, Rim101p, Fkh2p and Tec1p, decreased under conditions that repress CDC28 expression. Taken together, these data indicate that repression of CDC28 affected the protein levels of the morphology‐related transcription factors, the regulation of hyphae‐specific genes and cell shape in C. albicans. Copyright © 2006 John Wiley & Sons, Ltd.
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Depletion of the CDK Cdc28 results in variable filamentous morphologies.
“Depletion of the CDK Cdc28 results in variable filamentous morphologies, and other major regulators of cell cycle progression, including the polo-like kinase Cdc5 and the CDK inhibitor Sol1, also have a strong influence on growth morphology (Bachewich et al., 2003; Atir-Lande et al., 2005; Umeyama et al., 2006).”
From Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in<i>Candida albicans</i> (2012) · cites this paper as Umeyama et al., 2006
In C. albicans, Cdc28 is normally present at constant levels throughout the cell cycle.
“In C. albicans, Cdc28 is normally present at constant levels throughout the cell cycle, and its depletion was demonstrated to cause filamentous growth (Umeyama et al., 2006).”
From Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in<i>Candida albicans</i> (2012) · cites this paper as Umeyama et al., 2006
Depletion of Cdc28 in C. albicans causes filamentous growth.
“In C. albicans, Cdc28 is normally present at constant levels throughout the cell cycle, and its depletion was demonstrated to cause filamentous growth (Umeyama et al., 2006).”
From Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in<i>Candida albicans</i> (2012) · cites this paper as Umeyama et al., 2006
Cites
Nonfilamentous C. albicans Mutants Are Avirulent
Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809 · see citing works
Isogenic strain construction and gene mapping in Candida albicans.
Fonzi, W. A., & Irwin, M. Y. (1993) · Genetics · doi:10.1093/genetics/134.3.717 · Cited by 1,695 · see citing works
Genetic Control of the Cell Division Cycle in Yeast
Hartwell, L. H., Culotti, J. G., Pringle, J. R., & Reid, B. J. (1974) · Science · doi:10.1126/science.183.4120.46 · Cited by 1,567 · see citing works
Targets of the cyclin-dependent kinase Cdk1
Ubersax, J. A., Woodbury, E. L., Quang, P. N., Paraz, M., Blethrow, J. D., Shah, K., Shokat, K. M., & Morgan, D. O. (2003) · Nature · doi:10.1038/nature02062 · Cited by 892 · see citing works
The distinct morphogenic states of Candida albicans
Sudbery, P., Gow, N., & Berman, J. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.05.008 · Cited by 876 · see citing works
Suppression of Hyphal Formation in Candida albicans by Mutation of a STE12 Homolog
Liu, H., Köhler, J. R., & Fink, G. R. (1994) · Science · doi:10.1126/science.7992058 · Cited by 788 · see citing works
Rapid Hypothesis Testing with Candida albicans through Gene Disruption with Short Homology Regions
Wilson, R. B., Davis, D. A., & Mitchell, A. P. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.6.1868-1874.1999 · Cited by 763 · see citing works
Stoldt, V. R., Sonneborn, A., Leuker, C. E., & Ernst, J. F. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1982 · Cited by 595 · see citing works
Candida albicans: A molecular revolution built on lessons from budding yeast
Berman, J., & Sudbery, P. E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg948 · Cited by 578 · see citing works
Genetic Control of the Cell-Division Cycle in Yeast, I. Detection of Mutants
Hartwell, L. H., Culotti, J. G., & Reid, B. J. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.66.2.352 · Cited by 576 · see citing works
Control of Filament Formation in Candida albicans by the Transcriptional Repressor TUP1
Braun, B. R., & Johnson, A. D. (1997) · Science · doi:10.1126/science.277.5322.105 · Cited by 515 · see citing works
Isolation of genes by complementation in yeast: molecular cloning of a cell-cycle gene.
Nasmyth, K., & Reed, S. I. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.4.2119 · Cited by 497 · see citing works
NRG1 represses yeast–hypha morphogenesis and hypha‐specific gene expression in Candida albicans
Murad, A. M. A., Leng, P., Straffon, M., Wishart, J., Macaskill, S., MacCallum, D., Schnell, N., Talibi, D., Marechal, D., Tekaia, F., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4742 · Cited by 452 · see citing works
Mendenhall, M. D., & Hodge, A. E. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1191-1243.1998 · Cited by 429 · see citing works
REGULATORY GENES CONTROLLING MITOSIS IN THE FISSION YEAST SCHIZOSACCHAROMYCES POMBE
Nurse, P., & Thuriaux, P. (1980) · Genetics · doi:10.1093/genetics/96.3.627 · Cited by 370 · see citing works
Lorincz, A. T., & Reed, S. I. (1984) · Nature · doi:10.1038/307183a0 · Cited by 356 · see citing works
NRG1, a repressor of filamentous growth in C.albicans, is down‐regulated during filament induction
Braun, B. R., Kadosh, D., & Johnson, A. D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4753 · Cited by 345 · see citing works
Zheng, X., Wang, Y.-M., & Wang, Y. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600195 · Cited by 328 · see citing works
Shenoy, S. G., Choi, J., Bagrodia, S., Copeland, T. D., Maller, J. L., & Shalloway, D. I. (1989) · Cell · doi:10.1016/0092-8674(89)90791-5 · Cited by 316 · see citing works
Hindley, J. R., & Phear, G. A. (1984) · Gene · doi:10.1016/0378-1119(84)90203-8 · Cited by 313 · see citing works
Identification and Characterization of <i>TUP1</i>-Regulated Genes in <i>Candida albicans</i>
Braun, B. R., Head, W. S., Wang, M. X., & Johnson, A. D. (2000) · Genetics · doi:10.1093/genetics/156.1.31 · Cited by 306 · see citing works
RIM101-Dependent and -Independent Pathways Govern pH Responses in Candida albicans
Davis, D. A., Wilson, R. B., & Mitchell, A. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.971-978.2000 · Cited by 285 · see citing works
Kadosh, D., & Johnson, A. D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0073 · Cited by 285 · see citing works
Three Additional Genes Required for Deoxyribonucleic Acid Synthesis in Saccharomyces cerevisiae
Hartwell, L. H. (1973) · Journal of Bacteriology · doi:10.1128/jb.115.3.966-974.1973 · Cited by 273 · see citing works
Langan, T. A., Gautier, J., Lohka, M. J., Hollingsworth, R. E., Moreno, S., Nurse, P., Maller, J. L., & Sclafani, R. A. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.9.3860 · Cited by 263 · see citing works
Brown, D. H., Jr., Giusani, A. D., Chen, X., & Kumamoto, C. A. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01619.x · Cited by 262 · see citing works
Symmetric cell division in pseudohyphae of the yeast Saccharomyces cerevisiae.
Kron, S. J., Styles, C. A., & Fink, G. R. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.9.1003 · Cited by 249 · see citing works
Birse, C., Irwin, M. Y., Fonzi, W. A., & Sypherd, P. S. (1993) · Infection and Immunity · doi:10.1128/iai.61.9.3648-3655.1993 · Cited by 248 · see citing works
Transcriptional control of dimorphism in Candida albicans
Liu, H. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(01)00275-2 · Cited by 244 · see citing works
Schweizer, A., Rupp, S., Taylor, B. N., Röllinghoff, M., & Schröppel, K. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02132.x · Cited by 232 · see citing works
APSES Proteins Regulate Morphogenesis and Metabolism in Candida albicans
Doedt, T., Krishnamurthy, S., Bockmühl, D. P., Tebarth, B., Stempel, C., Russell, C. L., Brown, A. J. P., & Ernst, J. F. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0782 · Cited by 232 · see citing works
Lane, S., Birse, C., Zhou, S., Matson, R., & Liu, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104484200 · Cited by 220 · see citing works
Murad, A. M. A., D'Enfert, C., Gaillardin, C., Tournu, H., Tekaia, F., Talibi, D., Marechal, D., Marchais, V., Cottin, J., & Brown, A. J. P. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02713.x · Cited by 208 · cited 4× · see citing works
“…show polarized or pseudohyphal growth, including cells treated with hydroxyurea (Bachewich et al., 2005) or cells depleted for NRG1, TUP1 (GarciaSanchez et al., 2005; Kadosh and Johnson, 2005; Murad et al., 2001a; Murad et al., 2001b), CDC5 (Bachewich et al., 2005) or FKH2 (Bensen et al., 2002).”
BackgroundInfluentialA Single-Transformation Gene Function Test in Diploid Candida albicans
Enloe, B. M., Diamond, A. E., & Mitchell, A. P. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.20.5730-5736.2000 · Cited by 204 · see citing works
The <i>Candida albicans CaACE2</i> gene affects morphogenesis, adherence and virulence
Kelly, M. T., MacCallum, D. M., Clancy, S. D., Odds, F. C., Brown, A. J. P., & Butler, G. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04185.x · Cited by 175 · see citing works
Bockmühl, D. P., & Ernst, J. F. (2001) · Genetics · doi:10.1093/genetics/157.4.1523 · Cited by 170 · see citing works
Sharkey, L. L., McNemar, M. D., Saporito-Irwin, S. M., Sypherd, P. S., & Fonzi, W. A. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.17.5273-5279.1999 · Cited by 168 · see citing works
Mendenhall, M. D., Jones, C. A., & Reed, S. I. (1987) · Cell · doi:10.1016/0092-8674(87)90519-8 · Cited by 167 · see citing works
Bensen, E. S., Filler, S. G., & Berman, J. G. (2002) · Eukaryotic Cell · doi:10.1128/ec.1.5.787-798.2002 · Cited by 122 · see citing works
Lane, S., Zhou, S., Pan, T., Dai, Q., & Liu, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6418-6428.2001 · Cited by 118 · see citing works
Garcı́a, S. C., Mavor, A. L., Russell, C. L., Argimón, S., Dennison, P., Enjalbert, B., & Brown, A. J. P. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0071 · Cited by 115 · see citing works
Hyphal Elongation Is Regulated Independently of Cell Cycle inCandida albicans
Hazan, I., Sepulveda-Becerra, M., & Liu, H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-03-0116 · Cited by 111 · see citing works
A G<sub>1</sub> Cyclin Is Necessary for Maintenance of Filamentous Growth in <i>Candida albicans</i>
Loeb, J. D. J., Sepulveda-Becerra, M., Hazan, I., & Liu, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4019 · Cited by 105 · see citing works
Bachewich, C., Nantel, A., & Whiteway, M. S. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04727.x · Cited by 101 · see citing works
Wightman, R., Bates, S., Amornrrattanapan, P., & Sudbery, P. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307176 · Cited by 100 · see citing works
Candida albicans Rim13p, a Protease Required for Rim101p Processing at Acidic and Alkaline pHs
Li, M., Martin, S. J., Bruno, V. M., Mitchell, A. P., & Davis, D. A. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.3.741-751.2004 · Cited by 100 · see citing works
Barkani, A. E., Kurzai, O., Fonzi, W. A., Ramón, A., Porta, A., Frosch, M., & Mühlschlegel, F. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4635-4647.2000 · Cited by 96 · see citing works
The Mitotic Cyclins Clb2p and Clb4p Affect Morphogenesis in<i>Candida albicans</i>
Bensen, E. S., Clemente-Blanco, A., Finley, K. R., Correa-Bordes, J., & Berman, J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-12-1081 · Cited by 94 · cited 5× · see citing works
“albicans morphogenesis by negatively regulating polarized growth (Bensen et al., 2005).”
BackgroundResultInfluentialCyclin Cln3p Links G 1 Progression to Hyphal and Pseudohyphal Development in Candida albicans
Bachewich, C., & Whiteway, M. S. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.1.95-102.2005 · Cited by 86 · see citing works
Depletion of a Polo-like Kinase inCandida albicansActivates Cyclase-dependent Hyphal-like Growth
Bachewich, C., Thomas, D. Y., & Whiteway, M. S. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.02-05-0076 · Cited by 83 · see citing works
Pic‐Taylor, A., Darieva, Z. A., Morgan, B. A., & Sharrocks, A. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.10036-10046.2004 · Cited by 83 · see citing works
The G 1 Cyclin Cln3 Regulates Morphogenesis in Candida albicans
Chapa‐y‐Lazo, B., Bates, S., & Sudbery, P. E. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.1.90-94.2005 · Cited by 80 · see citing works
Bai, C. G., Ramanan, N., Wang, Y. M., & Wang, Y. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02995.x · Cited by 64 · see citing works
Tandem affinity purification of the Candida albicans septin protein complex
Kaneko, A., Umeyama, T., Hanaoka, N., Monk, B. C., Uehara, Y., & Niimi, M. (2004) · Yeast · doi:10.1002/yea.1147 · Cited by 57 · see citing works
Self-citationOhkuni, K., Hayashi, M., & Yamashita, I. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199805)14:7 · Cited by 57 · see citing works
Candida albicans protein kinase CaHsl1p regulates cell elongation and virulence
Umeyama, T., Kaneko, A., Nagai, Y., Hanaoka, N., Tanabe, K., Takano, Y., Niimi, M., & Uehara, Y. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04405.x · Cited by 55 · see citing works
Self-citationIshii, N., Yamamoto, M., Yoshihara, F., Arisawa, M., & Aoki, Y. (1997) · Microbiology · doi:10.1099/00221287-143-2-429 · Cited by 53 · see citing works
Rottmann, M., Dieter, S., Brunner, H., & Rupp, S. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03358.x · Cited by 47 · see citing works
Sherlock, G. J., Bahman, A. M., Mahal, A., Shieh, J., Ferreira, M. G., & Rosamond, J. (1994) · Molecular and General Genetics MGG · doi:10.1007/bf00297278 · Cited by 42 · see citing works
Hanaoka, N., Umeyama, T., Ueno, K., Uéda, K., Beppu, T., Fugo, H., Uehara, Y., & Niimi, M. (2005) · Microbiology · doi:10.1099/mic.0.27999-0 · Cited by 31 · see citing works
Self-citationIshii, N., Yamamoto, M., Lahm, H., Lizumi, S., Yoshihara, F., Nakayama, H., Arisawa, M., & Aoki, Y. (1997) · Microbiology · doi:10.1099/00221287-143-2-417 · Cited by 20 · see citing works
Damagnez, V., & Cottarel, G. (1996) · Gene · doi:10.1016/0378-1119(95)00893-4 · Cited by 14 · see citing works
A versatile microtiter assay for the universal cdc2 cell cycle regulator
Ducommun, B., & Beach, D. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90422-6 · Cited by 12 · see citing works
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Regulatory circuitry governing fungal development, drug resistance, and disease.
Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576 · see citing works
Morphogenesis in Candida albicans
Whiteway, M. S., & Bachewich, C. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093341 · Cited by 390 · see citing works
Global analysis of fungal morphology exposes mechanisms of host cell escape
O’Meara, T. R., Veri, A. O., Ketela, T., Jiang, B., Roemer, T., & Cowen, L. E. (2015) · Nature Communications · doi:10.1038/ncomms7741 · Cited by 243 · see citing works
Morphogenesis and cell cycle progression in Candida albicans
Berman, J. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.10.007 · Cited by 237 · see citing works
From Jekyll to Hyde: The Yeast–Hyphal Transition of Candida albicans
Chow, E. W. L., Pang, L. M., & Wang, Y. (2021) · Pathogens · doi:10.3390/pathogens10070859 · Cited by 144 · see citing works
Gong, Y., Li, T., Yu, C., & Sun, S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00520 · Cited by 101 · see citing works
Shapiro, R. S., Sellam, A., Tebbji, F., Whiteway, M., Nantel, A., & Cowen, L. E. (2012) · Current Biology · doi:10.1016/j.cub.2012.01.062 · Cited by 81 · see citing works
Senn, H., Shapiro, R. S., & Cowen, L. E. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-08-0729 · Cited by 67 · see citing works
O'Meara, T. R., & Cowen, L. E. (2014) · Cellular Microbiology · doi:10.1111/cmi.12266 · Cited by 48 · see citing works
Woolford, C. A., Lagree, K., Xu, W., Aleynikov, T., Adhikari, H., Sánchez, H., Cullen, P. J., Lanni, F., Andes, D. R., & Mitchell, A. P. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006487 · Cited by 46 · see citing works
Hussein, B., Huang, H., Glory, A., Osmani, A., Kaminskyj, S. G. W., Nantel, A., & Bachewich, C. (2011) · Eukaryotic Cell · doi:10.1128/ec.00278-10 · Cited by 39 · see citing works
MAPK Cell-Cycle Regulation in Saccharomyces Cerevisiae and Candida Albicans
Correia, I., Alonso‐Monge, R., & Plá, J. (2010) · Future Microbiology · doi:10.2217/fmb.10.72 · Cited by 33 · see citing works
Hossain, S., Lash, E., Veri, A. O., & Cowen, L. E. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108781 · Cited by 31 · see citing works
Sun, C., Zhao, X., Jiao, Z.-L., Peng, J., Zhou, L., Yang, L., Huang, M., Tian, C., & Guo, G. (2022) · Antibiotics · doi:10.3390/antibiotics11111474 · Cited by 30 · see citing works
Watchaputi, K., Jayasekara, L. A. C. B., Ratanakhanokchai, K., & Soontorngun, N. (2023) · Scientific Reports · doi:10.1038/s41598-023-36191-4 · Cited by 28 · see citing works
Sudbery, P. E., & Court, H. (2007) · Springer eBooks · doi:10.1007/978-3-540-70618-2_6 · Cited by 22 · see citing works
Wang, A., Lane, S., Tian, Z., Sharon, A., Hazan, I., & Liu, H. (2006) · Eukaryotic Cell · doi:10.1128/ec.00380-06 · Cited by 21 · see citing works
Chou, H., Glory, A., & Bachewich, C. (2011) · Eukaryotic Cell · doi:10.1128/ec.00263-10 · Cited by 20 · see citing works
Lee, Y., Hossain, S., MacAlpine, J., Robbins, N., & Cowen, L. E. (2023) · iScience · doi:10.1016/j.isci.2023.106145 · Cited by 18 · see citing works
Kadosh, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-50409-4_4 · Cited by 16 · see citing works
Ser or Leu: structural snapshots of mistranslation in Candida albicans
Sárkány, Z., Silva, A., Pereira, P. J. B., & Macedo‐Ribeiro, S. (2014) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2014.00027 · Cited by 10 · see citing works
Das, S., Goswami, A. M., & Saha, T. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105418 · Cited by 9 · see citing works
Sane, A., Sridhar, S., Sanyal, K., & Ghosh, S. (2021) · Molecular Microbiology · doi:10.1111/mmi.14796 · Cited by 7 · see citing works
Woolford, C. A., Lagree, K., Aleynikov, T., & Mitchell, A. P. (2017) · Current Genetics · doi:10.1007/s00294-017-0705-8 · Cited by 7 · see citing works
Lai, W., Hsu, H., Cheng, C., WANG, S., Li, W.-C., Hsieh, P.-S., Tseng, T.-L., Lin, T., & Shieh, J. (2022) · Journal of Fungi · doi:10.3390/jof8030233 · Cited by 2 · see citing works
PPI network identifies interacting pathogenic signaling pathways in Candida albicans
Chattopadhyay, D., Das, S., Mondal, P. S., Mondal, T., Samanta, S., Mondal, A., Goswami, A. M., & Saha, T. (2025) · Molecular Omics · doi:10.1039/d5mo00042d · Cited by 1 · see citing works
Möslinger, A., Weiner, A., Schäuble, S., Ramı́rez-Zavala, B., Jablonowski, N., Cseresnyés, Z., Schille, T. B., Figge, M. T., Panagiotou, G., Morschhäuser, J., et al. (2026) · mBio · doi:10.1128/mbio.01764-26 · Cited by 1 · see citing works
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Gale, C. A., & Berman, J. G. (2014) · ASM Press eBooks · doi:10.1128/9781555817176.ch8 · Cited by 1 · see citing works
(2007) · Yeast · doi:10.1002/yea.1323
Dantuslia, S. K., Prajapati, B., & Prabha, C. R. (2026) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-026-02041-z
- Authors
- Umeyama, T., Kaneko, A., Niimi, M., & Uehara, Y.
- Affiliations
- National Institute of Infectious Diseases (JP)
- Corresponding author
- Uehara, Yoshimasa
- ORCID
- Umeyama, Takashi
- Venue
- Yeast
- Publisher
- Wiley
- Published
- 2006-05
- Volume
- 23
- Issue
- 7
- Pages
- 537-552
- ISSN
- 0749-503X (ISSN-L)
- 1097-0061
- OpenAlex
- W2051753426
- Cited by
- 31
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2012: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Yeast (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Science and Technology Corporation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida albicans, Cdc28, cyclin-dependent kinases, cell morphology, hyphal morphogenesis, cell cycle, conditional mutants, HWP1, endothelin-converting enzyme-1, cell elongation, polarized growth, transcription factors
- MeSH terms
- Candida albicans, Cell Cycle, DNA, Fungal, Fungal Proteins, Morphogenesis, Transcription Factors, Transcription, Genetic, Gene Expression Regulation, Fungal, Mutagenesis, Insertional, CDC2-CDC28 Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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