Candida albicans: A molecular revolution built on lessons from budding yeast
Abstract
Candida albicans is an opportunistic fungal pathogen that is found in the normal gastrointestinal flora of most healthy humans. However, in immunocompromised patients, blood-stream infections often cause death, despite the use of anti-fungal therapies. The recent completion of the C. albicans genome sequence, the availability of whole-genome microarrays and the development of tools for rapid molecular-genetic manipulations of the C. albicans genome are generating an explosion of information about the intriguing biology of this pathogen and about its mechanisms of virulence. They also reveal the extent of similarities and differences between C. albicans and its benign relative, Saccharomyces cerevisiae.
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The related yeast S. cerevisiae and C. albicans diverged more than 140 million years ago, but primary biological processes as well as major effectors governing them are still conserved in both organisms.
“The related yeast S. cerevisiae and C. albicans diverged more than 140 million years ago, but primary biological processes as well as major effectors governing them are still conserved in both organisms (Berman and Sudbery 2002).”
From Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor (2005) · cites this paper as Berman and Sudbery 2002
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The Ess1 Prolyl Isomerase Is Required for Growth and Morphogenetic Switching inCandida albicans
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Candida albicans INT1 -Induced Filamentation in Saccharomyces cerevisiae Depends on Sla2p
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Self-citationAnalysis of Telomerase in Candida albicans : Potential Role in Telomere End Protection
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<i>Candida albicans</i> pathogenicity mechanisms
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<i>Candida albicans</i> Secreted Aspartyl Proteinases in Virulence and Pathogenesis
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The distinct morphogenic states of Candida albicans
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Self-citationRegulatory circuitry governing fungal development, drug resistance, and disease.
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<i>Candida albicans</i> dimorphism as a therapeutic target
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Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.
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Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling
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Stress adaptation in a pathogenic fungus
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The ‘obligate diploid’ Candida albicans forms mating-competent haploids
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Self-citationRecent insights into Candida albicans biofilm resistance mechanisms
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<i>CRZ1</i> , a target of the calcineurin pathway in <i>Candida albicans</i>
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Calcineurin Is Essential for <i>Candida albicans</i> Survival in Serum and Virulence
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Candida auris: Disinfectants and Implications for Infection Control
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Targeting<i>Candida albicans</i>filamentation for antifungal drug development
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Fungal Strategies to Evade the Host Immune Recognition
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Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy
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Cyclin-Dependent Kinases Control Septin Phosphorylation in Candida albicans Hyphal Development
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Haploidy, diploidy and evolution of antifungal drug resistance in Saccharomyces cerevisiae
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Fungal invasion of epithelial cells
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Adaptation of <i>Candida albicans</i> to Reactive Sulfur Species
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- Authors
- Berman, J., & Sudbery, P. E.
- Affiliations
- University of Minnesota (US)
- University of Sheffield (GB)
- Corresponding author
- Berman, Judith
- Venue
- Nature Reviews Genetics
- Published
- 2002-12-01
- Volume
- 3
- Issue
- 12
- Pages
- 918-931
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2001652771
- Semantic Scholar
- 89c3edc97059524cecd71c5078c25f86ae8774cc
- Cited by
- 578
- References
- 118
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 28 · 2021: 27 · 2020: 25 · 2019: 23 · 2018: 25 · 2017: 30 · 2016: 27 · 2015: 30 · 2014: 31 · 2013: 27 · 2012: 21
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health
- National Research Council Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida albicans, opportunistic fungal pathogens, candidemia, whole genome microarray, Saccharomyces cerevisiae, comparative genomics, immunocompromised patients
- MeSH terms
- Candida albicans, Morphogenesis, Phenotype, Saccharomyces cerevisiae, Transcription, Genetic, Transfection, Signal Transduction, Mutagenesis, Genome, Fungal, Gene Deletion
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