Cited by 578Fungal and yeast genetics researchAntifungal resistance and susceptibilityYeasts and Rust Fungi Studies

Candida albicans: A molecular revolution built on lessons from budding yeast

Berman, Judith, Sudbery, Peter E.·2002·Nature Reviews Genetics

Abstract

Candida albicans is an opportunistic fungal pathogen that is found in the normal gastrointestinal flora of most healthy humans. However, in immunocompromised patients, blood-stream infections often cause death, despite the use of anti-fungal therapies. The recent completion of the C. albicans genome sequence, the availability of whole-genome microarrays and the development of tools for rapid molecular-genetic manipulations of the C. albicans genome are generating an explosion of information about the intriguing biology of this pathogen and about its mechanisms of virulence. They also reveal the extent of similarities and differences between C. albicans and its benign relative, Saccharomyces cerevisiae.

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Crossref · 10.1038/nrg948

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  • The related yeast S. cerevisiae and C. albicans diverged more than 140 million years ago, but primary biological processes as well as major effectors governing them are still conserved in both organisms.

    “The related yeast S. cerevisiae and C. albicans diverged more than 140 million years ago, but primary biological processes as well as major effectors governing them are still conserved in both organisms (Berman and Sudbery 2002).”

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Authors
Berman, J., & Sudbery, P. E.
Affiliations
  • University of Minnesota (US)
  • University of Sheffield (GB)
Corresponding author
Berman, Judith
Venue
Nature Reviews Genetics
Published
2002-12-01
Volume
3
Issue
12
Pages
918-931
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2001652771
Cited by
578
References
118
Citations by year
2026: 8 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 28 · 2021: 27 · 2020: 25 · 2019: 23 · 2018: 25 · 2017: 30 · 2016: 27 · 2015: 30 · 2014: 31 · 2013: 27 · 2012: 21
FWCI
1.80
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • National Institutes of Health
  • National Research Council Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords
Candida albicans, opportunistic fungal pathogens, candidemia, whole genome microarray, Saccharomyces cerevisiae, comparative genomics, immunocompromised patients
MeSH terms
Candida albicans, Morphogenesis, Phenotype, Saccharomyces cerevisiae, Transcription, Genetic, Transfection, Signal Transduction, Mutagenesis, Genome, Fungal, Gene Deletion

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