Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid

Wisniewski, T.; Golabek, A.; Matsubara, E.; Ghiso, J.; Frangione, B.

doi:10.1006/bbrc.1993.1423

Cited by 212

The DOI matches its Crossref record.

Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid

Wisniewski, T., Golabek, A., Matsubara, E., Ghiso, J., Frangione, B.·1993·Biochemical and Biophysical Research Communications

DOI 10.1006/bbrc.1993.1423

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Abstract

Apolipoprotein E (apo E) is associated with Alzheimer's beta-amyloid (A beta) in senile plaques. A beta is now known to be a normal soluble peptide (sA beta) found in the cerebrospinal fluid (CSF) and other biological fluids. We have used synthetic A beta peptides bound to affinity membranes in order to determine whether apo E or any other amyloid associated protein will bind to these membranes, when they are bathed in CSF. Under these conditions apo E, as well as another apolipoprotein, apolipoprotein J (Apo J), bound to the membranes. Using ELISA and ligand binding studies, we found a high avidity binding of A beta peptides to apo E. This suggests that apo E, as well as other related proteins may bind not only amyloid A beta but also sA beta. This interaction may be critical in amyloid formation.

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In brain, plasma, and cerebrospinal fluid as well as in senile plaques Aβ is associated to apolipoprotein E (apoE).
“In the brain, plasma, and cerebrospinal fluid as well as in senile plaques A␤ is associated to apolipoprotein E (apoE) (16 -18).”
From Internalization of β-Amyloid Peptide by Primary Neurons in the Absence of Apolipoprotein E (2007) · cites this paper as [18]

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Authors: Wisniewski, T., Golabek, A., Matsubara, E., Ghiso, J., & Frangione, B.
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 1993-04
Volume: 192
Issue: 2
Pages: 359-365
ISSN: 0006-291X
DOI: 10.1006/bbrc.1993.1423
Cited by: 212
References: 0
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid

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