APOE is a major susceptibility gene for Alzheimer’s disease

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525 · see citing works

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363 · see citing works

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157 · see citing works

Apolipoprotein E polymorphism and Alzheimer's disease

Poirier, J., Bertrand, P., Poirier, J., Kogan, S., Gauthier, S., Poirier, J., Gauthier, S., Davignon, J., Bouthillier, D., & Davignon, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91705-q · Cited by 1,108 · see citing works

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Cai, X.-D., Golde, T. E., & Younkin, S. G. (1993) · Science · doi:10.1126/science.8424174 · Cited by 913 · see citing works

The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease

Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818 · see citing works

Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases

Saunders, A. M., Roses, A. D., Pericak‐Vance, M. A., Dole, K. C., Strittmatter, W. J., Schmechel, D. E., Szymanski, M. H., McCown, N., Manwaring, M., Schmader, K. E., et al. (1993) · The Lancet · doi:10.1016/0140-6736(93)91709-u · Cited by 498 · see citing works

Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

van Duijn, C. M., de Knijff, P., Cruts, M., Wehnert, A., Havekes, L. M., Albert Hofman, D., & Broeckhoven, C. V. (1994) · Nature Genetics · doi:10.1038/ng0594-74 · Cited by 453 · see citing works

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

Chartier‐Harlin, M., Parfitt, M., Legrain, S., Pérez‐Tur, J., Brousseau, T., Evans, A., Berr, C., Vldal, O., Roques, P. K., Gourlet, V., et al. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.4.569 · Cited by 437 · see citing works

Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype

Strittmatter, W. J., Weisgraber, K. H., Goedert, M., Saunders, A. M., Huang, D., Corder, E. H., Dong, L., Jakes, R., Alberts, M. J., Gilbert, J. R., et al. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1019 · Cited by 433 · see citing works

The apolipoprotein ε4 allele in patients with Alzheimer's disease

Mayeux, R. P., Stern, Y., Ottman, R., Tatemichi, T. K., Tang, M., Maestre, G. E., Ngai, C. I., Tycko, B., & Ginsberg, H. N. (1993) · Annals of Neurology · doi:10.1002/ana.410340527 · Cited by 414 · see citing works

Apolipoprotein E Affects the Rate of Alzheimer Disease Expression: β-Amyloid Burden Is a Secondary Consequence Dependent on APOE Genotype and Duration of Disease

Roses, A. D. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00002 · Cited by 329 · see citing works

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

Diedrich, J. F., Minnigan, H. J., Carp, R. I., Whitaker, J. N., Race, R., Frey, W. H., & Haase, A. T. (1991) · Journal of Virology · doi:10.1128/jvi.65.9.4759-4768.1991 · Cited by 295 · see citing works

The Lack of Accumulation of Senile Plaques or Amyloid Burden in Alzheimer's Disease Suggests a Dynamic Balance Between Amyloid Deposition and Resolution

Hyman, B., Marzloff, K., & Arriagada, P. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199311000-00006 · Cited by 294 · see citing works

APOLIPOPROTEIN-E GENOTYPE AND ALZHEIMERS-DISEASE

Hardy, J., Houlden, H., Collinge, J., Kennedy, A. M., Newman, S., Rossor, M. N., Lannfelt, L., Lilius, L., Winblad, B. G., Crook, R., et al. (1993) · UCL Discovery (University College London) · Cited by 286 · see citing works

Apolipoprotein E genotype and Alzheimer's disease

Noguchi, S., Murakami, K., Yamada, N., Payami, H., Kaye, J. A., Heston, L. L., Bird, T. D., & Schellenberg, G. D. (1993) · The Lancet · doi:10.1016/0140-6736(93)91728-5 · Cited by 285 · see citing works

Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

Sparks, D. L., Hunsaker, J. C., Scheff, S. W., Kryscio, R. J., Henson, J. L., & Markesbery, W. R. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90024-t · Cited by 271 · see citing works

Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid

Wısnıewskı, T., Golabek, A. A., Matsubara, E., Ghiso, J. A., & Frangione, B. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1423 · Cited by 265 · see citing works

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

Han, S.-H., Einstein, G., Weisgraber, K. H., Strittmatter, W. J., Saunders, A. M., Pericak-Vance, M., Roses, A. D., & Schmechel, D. E. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00013 · Cited by 195 · see citing works

The Seminal Role of β-Amyloid in the Pathogenesis of Alzheimer Disease

Joachim, C. L., & Selkoe, D. J. (1992) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199205000-00003 · Cited by 181 · see citing works

Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls

Han, S., Hulette, C., Saunders, A. M., Einstein, G., Pericak‐Vance, M. A., Strittmatter, W. J., Roses, A. D., & Schmechel, D. E. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1108 · Cited by 155 · see citing works

ApoE–ε4 and early–onset Alzheimer's

Okuizumi, K., Onodera, O., Tanaka, H., Kobayashi, H., Tsuji, S., Takahashi, H., Oyanagi, K., Seki, K., Tanaka, M., Naruse, S., et al. (1994) · Nature Genetics · doi:10.1038/ng0594-10b · Cited by 132 · see citing works

Alzheimer's Disease and Possible Gene Interaction

George‐Hyslop, P. S., McLachlan, D. C., Tsuda, T., Rogaev, E. I., Karlinsky, H., Lippa, C. F., & Pollen, D. A. (1994) · Science · doi:10.1126/science.8290965 · Cited by 132 · see citing works

Clinical application of apolipoprotein E genotyping to Alzheimer's disease

Roses, A., Strittmatter, W., Pericak-Vance, M., Corder, E., Saunders, A., & Schmechel, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92960-2 · Cited by 125 · see citing works

Confirmation of the ϵ4 allele of the apolipoprotein E gene as a risk factor for late‐onset Alzheimer's disease

Brousseau, T., Legrain, S., Berr, C., Gourlet, V., Vidal, O., & Amouyel, P. (1994) · Neurology · doi:10.1212/wnl.44.2.342 · Cited by 113 · see citing works

Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques

Einstein, G., Buranosky, R., & Crain, B. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-05077.1994 · Cited by 106 · see citing works

Molecular genetics in neurology

Martin, J. B. (1993) · Annals of Neurology · doi:10.1002/ana.410340603 · Cited by 66 · see citing works

Apolipoprotein E-∈A allele and Alzheimer's disease

Anwar, N. M., Lovestone, S., Cheetham, M. E., Levy, R., Powell, J. F., Amouyel, P., Brousseau, T., Fruchart, J., Dallongeville, J., Lucotte, G., et al. (1993) · The Lancet · doi:10.1016/0140-6736(93)92404-h · Cited by 66 · see citing works

Immediate intracardiac adrenaline injection in asystole

Eldor, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91729-6 · Cited by 65 · see citing works

Linkage of late-onset Alzheimer's disease with apolipoprotein E type 4 on chromosome 19

Borgaonkar, D., Schmidt, L., Martin, S. E., Kanzer, M. D., Edelsohn, L., Growdon, J. H., & Farrer, L. A. (1993) · The Lancet · doi:10.1016/0140-6736(93)91458-x · Cited by 65 · see citing works

ApoE ϵ4 allelic association with Alzheimer's disease

Peacock, M. L., & Fink, J. K. (1994) · Neurology · doi:10.1212/wnl.44.2.339 · Cited by 58 · see citing works

β A4 amyloid protein and its precursor in Alzheimer's disease

Bush, A. I., Beyreuther, K. T., & Masters, C. L. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90039-3 · Cited by 31 · see citing works

Apolipoprotein E ε4

Sakoda, S., Kuriyama, M., Osame, M., et al. (1994) · Neurology · doi:10.1212/wnl.44.12.2420 · Cited by 31 · see citing works

ApoE, Amyloid, and Alzheimer's Disease

Hardy, J. (1994) · Science · doi:10.1126/science.8290946 · Cited by 20 · see citing works

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050 · see citing works

Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans

Hua, X., Hibar, D. P., Lee, S., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.033 · Cited by 234 · see citing works

Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies

Sinsky, J., Pichlerova, K., & Hanes, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179207 · Cited by 220 · see citing works

Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD

Sjögren, M., Rosengren, L., Minthon, L., Davidsson, P., Blennow, K., & Wallin, A. (2000) · Neurology · doi:10.1212/wnl.54.10.1960 · Cited by 181 · see citing works

Clinically Significant Non-Major Depression: Old Concepts, New Insights

Lavretsky, H., & Kumar, A. (2002) · The American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200205000-00003 · Cited by 147 · see citing works

Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”

Tesseur, I., Lo, A. C., Roberfroid, A., Dietvorst, S., Van Broeck, B., Borgers, M., Gijsen, H., Moechars, D., Mercken, M., Kemp, J., et al. (2013) · Science · doi:10.1126/science.1233937 · Cited by 128 · see citing works

Genetic architecture of Alzheimer's disease

Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126 · see citing works

Inquiring Relation between Apolipoprotein E Gene Polymorphysm and the Alzheimer Disease

Shao, H. (2001) · Xiandai linchuang yixue shengwu gongchengxue zazhi · Cited by 1 · see citing works

The antimorphic nature of the Tc allele at the mouse T locus.

Macmurray, A., & Shin, H. (1988) · Genetics · doi:10.1093/genetics/120.2.545 · Cited by 43 · see citing works

Effects of milk protein loci on content of their proteins

Graml, R., & Pirchner, F. (2003) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-46-331-2003 · Cited by 29 · see citing works

[Analysis of rare alleles of D13S325 falling in the range of adjacent locus].

Chen, W., Peng, S., Wang, Y., et al. (2014) · PubMed · doi:10.3760/cma.j.issn.1003-9406.2014.02.026

[Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease].

Коровайцева, Г. И., Tv, S., Nv, S., et al. (2001) · PubMed · Cited by 17 · see citing works