Cited by 179Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.

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Gearing, M, Rebeck, G W, Hyman, B T, Tigges, J, Mirra, S S·1994·Proceedings of the National Academy of Sciences

Abstract

Neuropathological findings in three aged chimpanzees were compared with those in rhesus monkeys and individuals with Alzheimer disease. Senile plaques and blood vessels were immunoreactive for amyloid beta-protein and apolipoprotein E (apoE) in the nonhuman primates, recapitulating findings in human aging and Alzheimer disease. Neurofibrillary tangles, another hallmark of Alzheimer disease, were absent. PCR/restriction-enzyme analysis in chimpanzees revealed an APOE profile similar to the human APOE type 4 allele associated with an increased risk of Alzheimer disease. These findings militate against the hypothesis that the absence of APOE type 3 allele predisposes to neurofibrillary tangle formation and support the value of aged primates for exploring mechanisms of amyloid processing and the role of apoE.

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Crossref · 10.1073/pnas.91.20.9382

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Authors
Gearing, M., Rebeck, G. W., Hyman, B. T., Tigges, J., & Mirra, S. S.
Affiliations
  • Emory University (US)
  • Harvard University (US)
Venue
Proceedings of the National Academy of Sciences
Published
1994-09-27
Volume
91
Issue
20
Pages
9382-9386
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1976722506
Cited by
179
References
70
Citations by year
2025: 7 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 11 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 7
FWCI
3.17
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • National Institutes of Health (1f32ag005598-01, RR‐00165)
  • National Institute on Aging (P30AG010130, AG-10130, AG05598, AG00001)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
chimpanzees, Alzheimer's disease, apolipoprotein E, APOE ε4, amyloid-beta, amyloid plaques, neurofibrillary tangles, rhesus monkeys, APOE genotype, amyloid processing
MeSH terms
Aging, Alleles, Alzheimer Disease, Animals, Apolipoproteins E, Base Sequence, Brain, Pan troglodytes, Female, Genotype, Humans, Macaca mulatta, Male, Microscopy, Electron, Molecular Sequence Data, Polymerase Chain Reaction, Amyloid beta-Peptides, Neurofibrillary Tangles, DNA Primers

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