Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.
Open accessAbstract
Neuropathological findings in three aged chimpanzees were compared with those in rhesus monkeys and individuals with Alzheimer disease. Senile plaques and blood vessels were immunoreactive for amyloid beta-protein and apolipoprotein E (apoE) in the nonhuman primates, recapitulating findings in human aging and Alzheimer disease. Neurofibrillary tangles, another hallmark of Alzheimer disease, were absent. PCR/restriction-enzyme analysis in chimpanzees revealed an APOE profile similar to the human APOE type 4 allele associated with an increased risk of Alzheimer disease. These findings militate against the hypothesis that the absence of APOE type 3 allele predisposes to neurofibrillary tangle formation and support the value of aged primates for exploring mechanisms of amyloid processing and the role of apoE.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
PCR protocols — A guide to methods and applications
(1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90186-a · Cited by 11,826 · see citing works
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Self-citationThe precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619 · see citing works
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431 · see citing works
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028 · see citing works
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works
Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676 · see citing works
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933 · see citing works
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499 · see citing works
Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525 · see citing works
Kosik, K. S., Joachim, C. L., & Selkoe, D. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4044 · Cited by 1,462 · see citing works
A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
Lee, V. M.-Y., Balin, B. J., Otvos, L., & Trojanowski, J. Q. (1991) · Science · doi:10.1126/science.1899488 · Cited by 1,418 · see citing works
Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363 · see citing works
Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157 · see citing works
Apolipoprotein E polymorphism and Alzheimer's disease
Poirier, J., Bertrand, P., Poirier, J., Kogan, S., Gauthier, S., Poirier, J., Gauthier, S., Davignon, J., Bouthillier, D., & Davignon, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91705-q · Cited by 1,108 · see citing works
Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works
Self-citationWischik, C. M., Novak, M., Thøgersen, H. C., Edwards, P. C., Runswick, M. J., Jakes, R., Walker, J. E., Milstein, C., Roth, M., & Klug, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4506 · Cited by 939 · see citing works
Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid
Wisniewski, T., & Frangione, B. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90444-c · Cited by 802 · see citing works
Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.
(1991) · Europe PMC (PubMed Central) · Cited by 758 · see citing works
Wood, J. G., Mirra, S. S., Pollock, N. J., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4040 · Cited by 749 · see citing works
Self-citationKowal, R. C., Herz, J., Goldstein, J. L., Esser, V., & Brown, M. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5810 · Cited by 595 · see citing works
A Neuronal Antigen in the Brains of Alzheimer Patients
Wolozin, B. L., Pruchnicki, A., Dickson, D. W., & Davies, P. (1986) · Science · doi:10.1126/science.3083509 · Cited by 585 · see citing works
Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.
Greenberg, S. G., Davies, P., Schein, J., & Binder, L. I. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48531-6 · Cited by 542 · see citing works
Saunders, A. M., Roses, A. D., Pericak‐Vance, M. A., Dole, K. C., Strittmatter, W. J., Schmechel, D. E., Szymanski, M. H., McCown, N., Manwaring, M., Schmader, K. E., et al. (1993) · The Lancet · doi:10.1016/0140-6736(93)91709-u · Cited by 498 · see citing works
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
Selkoe, D. J., Bell, D., Podlisny, M., Price, D. L., & Cork, L. (1987) · Science · doi:10.1126/science.3544219 · Cited by 471 · see citing works
Strittmatter, W. J., Weisgraber, K. H., Goedert, M., Saunders, A. M., Huang, D., Corder, E. H., Dong, L., Jakes, R., Alberts, M. J., Gilbert, J. R., et al. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1019 · Cited by 433 · see citing works
The apolipoprotein ε4 allele in patients with Alzheimer's disease
Mayeux, R. P., Stern, Y., Ottman, R., Tatemichi, T. K., Tang, M., Maestre, G. E., Ngai, C. I., Tycko, B., & Ginsberg, H. N. (1993) · Annals of Neurology · doi:10.1002/ana.410340527 · Cited by 414 · see citing works
Formation of β-amyloid protein deposits in brains of transgenic mice
Quon, D. H., Wang, Y., Catalano, R., Scardina, J. M., Murakami, K., & Cordell, B. (1991) · Nature · doi:10.1038/352239a0 · Cited by 397 · see citing works
Beisiegel, U., Schneider, W. J., Goldstein, J. L., Anderson, R. G., & Brown, M. S. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68494-2 · Cited by 357 · see citing works
Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys
Wiśniewski, H. M., Ghetti, B., & Terry, R. D. (1973) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197310000-00007 · Cited by 272 · see citing works
Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid
Wısnıewskı, T., Golabek, A. A., Matsubara, E., Ghiso, J. A., & Frangione, B. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1423 · Cited by 265 · see citing works
Podlisny, M. B., Tolan, D. R., & Selkoe, D. J. (1991) · PubMed Central · Cited by 217 · see citing works
Senile plaques and cerebral amyloidosis in aged dogs. A histochemical and ultrastructural study.
Wisniewski, H., Ab, J., Raine, C. S., Wj, K., & Terry, R. D. (1970) · PubMed · Cited by 203 · see citing works
Senile plaques in cortex of aged normal monkeys.
Struble, R., Price, D. L., & Cork, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)91298-3 · Cited by 182 · see citing works
Alz‐50 Antibody recognizes alzheimer‐related neuronal changes
Hyman, B. T., Hoesen, G. W. V., Wolozin, B. L., Davies, P., Vogt, L. J., & Damasio, A. R. (1988) · Annals of Neurology · doi:10.1002/ana.410230410 · Cited by 176 · see citing works
Self-citationArai, H., Lee, V. M., Otvos, L. P., Greenberg, B., Lowery, D. E., Sharma, S., Schmidt, M. L., & Trojanowski, J. Q. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.6.2249 · Cited by 155 · see citing works
Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.
McLean, J. W., Elshourbagy, N. A., Chang, D. J., Mahley, R. W., & Taylor, J. M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82169-3 · Cited by 149 · see citing works
Amyloid precursor protein in aged nonhuman primates.
Martin, L. J., Sisodia, S. S., Koo, E. H., Cork, L. C., Dellovade, T., Weidemann, A., Beyreuther, K. T., Masters, C. L., & Price, D. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1461 · Cited by 146 · see citing works
Neurofibrillary Tangles and Senile Plaques in Aged Bears
Cork, L. C., Powers, R. E., Selkoe, D. J., Davies, P., Geyer, J. J., & Price, D. L. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198811000-00006 · Cited by 145 · see citing works
Aluminum chloride induced neurofibrillary changes in the developing rabbit: A chronic animal model
Wı́sniewski, H. M., Sturman, J. A., & Shek, J. W. (1980) · Annals of Neurology · doi:10.1002/ana.410080505 · Cited by 144 · see citing works
Rat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNA.
McLean, J. W., Fukazawa, C., & Taylor, J. M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32155-0 · Cited by 135 · see citing works
Hyman, B. T., Tanzi, R. E., Marzloff, K., Barbour, R., & Schenk, D. (1992) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199201000-00009 · Cited by 135 · see citing works
Self-citationMolecular systematics of higher primates: genealogical relations and classification.
Miyamoto, M. M., Koop, B. F., Slightom, J. L., GOODMAN, M. H., & Tennant, M. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.20.7627 · Cited by 124 · see citing works
Amyloid in the brains of aged squirrel monkeys
Walker, L. C., Masters, C., Beyreuther, K., & Price, D. L. (1990) · Acta Neuropathologica · doi:10.1007/bf00307691 · Cited by 119 · see citing works
Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.
Cork, L. C., Masters, C. L., Beyreuther, K. T., & Price, D. L. (1990) · Europe PMC (PubMed Central) · Cited by 112 · see citing works
Poduri, A., Gearing, M., Rebeck, G. W., Mirra, S. S., Tigges, J., & Hyman, B. T. (1994) · PubMed Central · Cited by 97 · see citing works
Self-citationCOMPARATIVE NEUROPATHOLOGY OF AGEING: STUDIES ON THE BRAINS OF 47 SPECIES OF VERTEBRATES
Dayan, A. D. (1971) · Brain · doi:10.1093/brain/94.1.31 · Cited by 95 · see citing works
Senile plaques in aged squirrel monkeys
Walker, L. C., Kitt, C. A., Schwam, E., Buckwald, B., Garcia, F., Sepinwall, J., & Price, D. L. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90067-4 · Cited by 94 · see citing works
Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit.
Rajavashisth, T. B., Kaptein, J. S., Reue, K., & Lusis, A. J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8085 · Cited by 92 · see citing works
Joachim, C. L., Games, D., Morris, J. R., Ward, P. J., Frenkel, D., & Selkoe, D. J. (1991) · PubMed Central · Cited by 88 · see citing works
King, F. A., Yarbrough, C. J., Anderson, D. C., Gordon, T. P., & Gould, K. G. (1988) · Science · doi:10.1126/science.3287624 · Cited by 88 · see citing works
Neve, R. L., Kammesheidt, A., & Höhmann, C. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3448 · Cited by 79 · see citing works
Molecular phylogeny of the family of apes and humans
Goodman, M., Koop, B. F., Czelusniak, J., Fitch, D. H. A., Tagle, D. A., & Slightom, J. L. (1989) · Genome · doi:10.1139/g89-050 · Cited by 77 · see citing works
α1-Antichymotrypsin is present together with the β-protein in monkey brain amyloid deposits
Abraham, C. R., Selkoe, D. J., Potter, H., Price, D. L., & Cork, L. C. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90292-3 · Cited by 74 · see citing works
Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology.
Richards, S. J., Waters, J. J., Beyreuther, K. T., Masters, C. L., Wischik, C. M., Sparkman, D. R., White, C. L., Abraham, C. R., & Dunnett, S. B. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07950.x · Cited by 62 · see citing works
The cytoarchitectonic distribution of senile plaques in three aged monkeys
Heilbroner, P. L., & Kemper, T. L. (1990) · Acta Neuropathologica · doi:10.1007/bf00662638 · Cited by 54 · see citing works
Hixson, J. E., Cox, L. A., & Borenstein, S. (1988) · Genomics · doi:10.1016/0888-7543(88)90020-1 · Cited by 41 · see citing works
Amyloid Precursor Protein (APP) in the Striatum in Alzheimerʼs Disease: An Immunohistochemical Study
Gearing, M., Wilson, R. W., Unger, E. R., Shelton, E. R., Chan, H. W., Masters, C. L., Beyreuther, K. T., & Mirra, S. S. (1993) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199301000-00004 · Cited by 40 · see citing works
Self-citationPhylogeny and molecular evolution in primates.
Hasegawa, M. (1990) · The Japanese Journal of Genetics · doi:10.1266/jjg.65.243 · Cited by 34 · see citing works
Alz-50 immunohistochemistry in the normal sheep striatum: a light and electron microscope study
Nelson, P. T., Marton, L. S., & Saper, C. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)91385-6 · Cited by 33 · see citing works
Bronson, R. T., & Schoene, W. C. (1980) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198003000-00007 · Cited by 31 · see citing works
The distribution of Alz-50 immunoreactivity in the normal human brain.
Rye, D. B., Leverenz, J., Greenberg, S. G., Davies, P., & Saper, C. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90567-y · Cited by 31 · see citing works
Nucleotide sequence of the cynomolgus monkey apolipoprotein E cDNA
Marotti, K. R., Whitted, B. E., Castle, C. K., Polites, H. G., & Melchior, G. W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.4.1778 · Cited by 25 · see citing works
Zannis, V. I., Nicolosi, R. J., Jensen, E., Breslow, J. L., & Hayes, K. C. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34247-4 · Cited by 23 · see citing works
Isolation and characterization of a full-length rabbit apolipoprotein E cDNA
Hao, Q., Yamin, T.-T., Pan, T., et al. (1987) · Atherosclerosis · doi:10.1016/0021-9150(87)90187-0 · Cited by 16 · see citing works
The Brain in Aged Elephants Reply
Cole, G., Neal, J. W., & Phil, D. (1990) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199003000-00012 · Cited by 13 · see citing works
Brzozowska, A., Fries, R., Womack, J. E., Grimholt, U., Myklebost, O., & Rogne, S. (1993) · Mammalian Genome · doi:10.1007/bf00364665 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Alzheimer's disease: experimental models and reality
Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810 · see citing works
Grandmothers and the evolution of human longevity
Hawkes, K. (2003) · American Journal of Human Biology · doi:10.1002/ajhb.10156 · Cited by 582 · see citing works
Human brain evolution: insights from microarrays
Preuss, T. M., Cáceres, M., Oldham, M. C., & Geschwind, D. H. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1469 · Cited by 215 · see citing works
Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy
Heuer, E., F. Rosen, R., Cintron, A., & C. Walker, L. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315885 · Cited by 169 · see citing works
Seeley, W. W., Allman, J. M., Carlin, D. A., Crawford, R. K., Macedo, M. N., Greicius, M. D., DeArmond, S. J., & Miller, B. L. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815c0f14 · Cited by 165 · see citing works
Tauopathy with paired helical filaments in an aged chimpanzee
Rosen, R. F., Farberg, A. S., Gearing, M., Dooyema, J., M. Long, P., Anderson, D. C., Davis‐Turak, J., Coppola, G., Geschwind, D. H., Paré, J., et al. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21744 · Cited by 153 · see citing works
Self-citationAnimal models of Alzheimer disease: historical pitfalls and a path forward
Cavanaugh, S. E. (2014) · ALTEX · doi:10.14573/altex.1310071 · Cited by 132 · see citing works
Human neoteny revisited: The case of synaptic plasticity
Bufill, E., Agustí, J., & Blesa, R. (2011) · American Journal of Human Biology · doi:10.1002/ajhb.21225 · Cited by 130 · see citing works
β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans
Gearing, M., Tigges, J., Mori, H., & Mirra, S. S. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00012-2 · Cited by 130 · see citing works
Self-citationMicroglia in Aging and Alzheimer’s Disease: A Comparative Species Review
Edler, M. K., Mhatre-Winters, I., & Richardson, J. R. (2021) · Cells · doi:10.3390/cells10051138 · Cited by 126 · see citing works
Tau isoform composition influences rate and extent of filament formation
Zhong, Q., Congdon, E. E., Nagaraja, H. N., & Kuret, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.364067 · Cited by 122 · see citing works
Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance
Bauernfeind, A. L., Barks, S. K., Duka, T., Grossman, L. I., Hof, P. R., & Sherwood, C. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0662-z · Cited by 105 · see citing works
Apolipoprotein E and Alzheimer's disease: the protective effects of ApoE2 and E3
Rebeck, G. W., Kindy, M., & LaDu, M. J. (2002) · Journal of Alzheimer's Disease · doi:10.3233/jad-2002-4304 · Cited by 89 · see citing works
Self-citationArnsten, A. F. T., Datta, D., Leslie, S., Yang, S.-T., Wang, M., & Nairn, A. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903671116 · Cited by 74 · see citing works
Aβ42 neurotoxicity in primary co-cultures: effect of apoE isoform and Aβ conformation
Manelli, A. M., Bulfinch, L. C., Sullivan, P. M., & LaDu, M. J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.024 · Cited by 72 · see citing works
Perez, S. E., Sherwood, C. C., Cranfield, M. R., Erwin, J. M., Mudakikwa, A., Hof, P. R., & Mufson, E. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.12.017 · Cited by 50 · see citing works
Senile Plaques in an Aged Western Lowland Gorilla.
KIMURA, N., NAKAMURA, S., GOTO, N., NARUSHIMA, E., HARA, I., SHICHIRI, S., SAITOU, K., NOSE, M., HAYASHI, T., KAWAMURA, S., et al. (2001) · Experimental Animals · doi:10.1538/expanim.50.77 · Cited by 46 · see citing works
Development of amyloid burden in African Green monkeys
Kalinin, S., Willard, S. L., Shively, C. A., Kaplan, J. R., Register, T. C., Jorgensen, M. J., Polak, P. E., Rubinstein, I., & Feinstein, D. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.023 · Cited by 32 · see citing works
- Authors
- Gearing, M., Rebeck, G. W., Hyman, B. T., Tigges, J., & Mirra, S. S.
- Affiliations
- Emory University (US)
- Harvard University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-09-27
- Volume
- 91
- Issue
- 20
- Pages
- 9382-9386
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC44816
- OpenAlex
- W1976722506
- Cited by
- 179
- References
- 70
- Citations by year
- 2025: 7 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 11 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 7
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (1f32ag005598-01, RR‐00165)
- National Institute on Aging (P30AG010130, AG-10130, AG05598, AG00001)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- chimpanzees, Alzheimer's disease, apolipoprotein E, APOE ε4, amyloid-beta, amyloid plaques, neurofibrillary tangles, rhesus monkeys, APOE genotype, amyloid processing
- MeSH terms
- Aging, Alleles, Alzheimer Disease, Animals, Apolipoproteins E, Base Sequence, Brain, Pan troglodytes, Female, Genotype, Humans, Macaca mulatta, Male, Microscopy, Electron, Molecular Sequence Data, Polymerase Chain Reaction, Amyloid beta-Peptides, Neurofibrillary Tangles, DNA Primers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review